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Sulfo-NHS plus EDC (carbodiimide) crosslinking reaction scheme
Carboxyl-to-amine crosslinking using the carbodiimide EDC and sulfo-NHS. Addition of NHS or Sulfo-NHS to EDC reactions (bottom-most pathway) increases efficiency and enables molecule (1) to be activated for storage and later use. NHS-activation is the basis for synthesizing amine-reactive labeling reagents and crosslinking compounds.
