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Product Details
24820-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
C1RL fusion protein Ag20324
Conjugate
Unconjugated
Form
Liquid
Concentration
0.7 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: SVLLAQELPQ QLTSPGYPEP YGKGQESSTD IKAPEGFAVR LVFQDFDLEP SQDCAGDSVT ISFVGSDPSQ FCGQQGSPLG RPPGQREFVS SGRSLRLTFR TQPSSENKTA HLHKGFLALY QTVAVNYSQP ISEASRGSEA INAPGDNPAK VQNHC
Target Information
Complement component 1, r subcomponent-like protein (C1rLP) is part of the complement system, primarily involved in innate immunity. Located on human chromosome 12p13.31, C1rLP is closely related to C1r, a serine protease component of the C1 complex in the classical pathway of complement activation. C1rLP shares structural similarities with C1r, featuring serine protease domains that are crucial for the proteolytic processing required to activate the complement cascade. The precise functional role of C1rLP remains under investigation, but it is hypothesized to act as a modulator of complement activation, potentially influencing immune cell behavior during inflammation or infection. The potential existence of several isoforms of C1rLP suggests diverse regulatory functions, which could impact processes like opsonization, pathogen clearance, and inflammation. Current research explores its relevance in immune response regulation, with implications for understanding autoimmune and inflammatory diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C1r-like protein; C1r-like serine protease analog protein; C1r-LP; CLSPa; Complement C1r subcomponent-like protein; complement C1r-like proteinase; complement component 1, r subcomponent like protein; complement component 1, r subcomponent-like
Gene Aliases: C1r-LP; C1RL; C1RL1; C1RLP; CLSPA
UniProt ID: (Human) Q9NZP8, (Mouse) Q3UZ09
Entrez Gene ID: (Human) 51279, (Mouse) 232371
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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