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Channelrhodopsin 2 (ChR2) is a cation-permeable channel protein that enables cell depolarisation in response to blue light. The antibody specifically detects the C terminus of ChR2. The epitope is located intracellularly between amino acids 290 and 309 of Chr2. This antibody was used in a Indirect ELISA.
A microbial type rhodopsin, ChR2 is a directly light-switched cation-selective ion channel. This channel opens rapidly after absorption of a photon to generate a large permeability for monovalent and divalent cations. ChR2 desensitizes in continuous light to a smaller steady-state conductance.
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