Product References
Protective anti-tumor vaccination against glioblastoma expressing the MHC class II transactivator CIITA.
Frontiers in immunology
Celesti F,Gatta A,Shallak M,Chiaravalli AM,Cerati M,Sessa F,Accolla RS,Forlani G
14-5321-82 was used in Immunohistochemistry-paraffin to report unprecedented positive results in terms of protection from glioblastoma growth in an animal experimental system after vaccination with glioblastoma GL261 cells stably expressing the MHC class II transactivator CIITA.
Fri Mar 31 00:00:00 UTC 2023
The meningeal transcriptional response to traumatic brain injury and aging.
eLife
Bolte AC,Shapiro DA,Dutta AB,Ma WF,Bruch KR,Kovacs MA,Royo Marco A,Ennerfelt HE,Lukens JR
14-5321-82 was used in Immunohistochemistry to find that aging alone induced upregulation of meningeal genes involved in antibody production by B cells and type I IFN signaling.
Tue Jan 03 00:00:00 UTC 2023
Chronic pulmonary bacterial infection facilitates breast cancer lung metastasis by recruiting tumor-promoting MHCIIhi neutrophils.
Signal transduction and targeted therapy
Ma T,Tang Y,Wang T,Yang Y,Zhang Y,Wang R,Zhang Y,Li Y,Wu M,Tang M,Hu X,Zou C,Ren Y,Liu H,Zhang Q,Li H,Wu M,Li J,Zhou X
14-5321-82 was used in Immunohistochemistry to reveal that chronic pulmonary bacterial infection augmented breast cancer lung metastasis by recruiting a distinct subtype of tumor-infiltrating MHCIIhi neutrophils into the lung, which exhibit cancer-promoting properties.
Fri Aug 11 00:00:00 UTC 2023
Identification of potential antigenic peptides of Brucella through proteome and peptidome.
Veterinary medicine and science
Pei M,Dong A,Ma X,Li S,Guo Y,Li M,Wang Z,Wang H,Zhu L,Pan C,Wang Y
14-5321-82 was used in Immunoprecipitation to indicate that the peptides we identified may be good candidate targets for the design of subunit vaccines and these results pave the way for the study of safer vaccines against Brucella.
Sun Jan 01 00:00:00 UTC 2023
Monocytes reprogrammed by tumor microparticle vaccine inhibit tumorigenesis and tumor development.
Cancer nanotechnology
Sun W,Dai L,Cao Y,Pan P,Zhi L,Wang X,Yuan X,Gao Z,Guo S,Liu G,Yin J,Xie L,Wang L,Wang Y,Li W,Li H,Jia Y
14-5321-82 was used in Flow cytometry/Cell sorting to provide novel vaccination strategy for the development of tumor vaccines and facilitate the application of T-MPs for clinic oncotherapy.
Tue Apr 25 00:00:00 UTC 2023
Side-Chain Immune Oxysterols Induce Neuroinflammation by Activating Microglia.
International journal of molecular sciences
Son Y,Yeo IJ,Hong JT,Eo SK,Lee D,Kim K
14-5321-82 was used in Immunohistochemistry to suggest that dysregulated cholesterol metabolism leading to elevated levels of side-chain oxysterols, such as 25OHChol and 27OHChol, can activate microglia to secrete IL-1β through a mechanism amenable to pharmacologic intervention.
Wed Oct 18 00:00:00 UTC 2023
Microglial STAT1-sufficiency is required for resistance to toxoplasmic encephalitis.
PLoS pathogens
Cowan MN,Kovacs MA,Sethi I,Babcock IW,Still K,Batista SJ,O'Brien CA,Thompson JA,Sibley LA,Labuzan SA,Harris TH
14-5321-82 was used in Immunohistochemistry to report that abrogation of STAT1 signaling in microglia, the resident immune cells of the CNS, is sufficient to induce a loss of parasite control in the CNS and susceptibility to toxoplasmic encephalitis during the early stages of chronic infection.
Thu Sep 01 00:00:00 UTC 2022
Gossypetin ameliorates 5xFAD spatial learning and memory through enhanced phagocytosis against Aβ.
Alzheimer's research & therapy
Jo KW,Lee D,Cha DG,Oh E,Choi YH,Kim S,Park ES,Kim JK,Kim KT
14-5321-82 was used in Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Neutralization, Western Blot to study how gossypetin showed protective effects against AD by enhancing microglial Aβ phagocytosis.
Fri Oct 21 00:00:00 UTC 2022
Listeria delivers tetanus toxoid protein to pancreatic tumors and induces cancer cell death in mice.
Science translational medicine
Selvanesan BC,Chandra D,Quispe-Tintaya W,Jahangir A,Patel A,Meena K,Alves Da Silva RA,Friedman M,Gabor L,Khouri O,Libutti SK,Yuan Z,Li J,Siddiqui S,Beck A,Tesfa L,Koba W,Chuy J,McAuliffe JC,Jafari R,Entenberg D,Wang Y,Condeelis J,DesMarais V,Balachandran V,Zhang X,Lin K,Gravekamp C
14-5321-82 was used in Immunohistochemistry-immunofluorescence to suggest that Listeria-delivered recall antigens could be an alternative to neoantigen-mediated cancer immunotherapy.
Wed Mar 23 00:00:00 UTC 2022
Single-cell analysis of skeletal muscle macrophages reveals age-associated functional subpopulations.
eLife
Krasniewski LK,Chakraborty P,Cui CY,Mazan-Mamczarz K,Dunn C,Piao Y,Fan J,Shi C,Wallace T,Nguyen C,Rathbun IA,Munk R,Tsitsipatis D,De S,Sen P,Ferrucci L,Gorospe M
14-5321-82 was used in Immunohistochemistry-immunofluorescence to identify dynamically polarized skeletal muscle (SKM) macrophages and propose that specific macrophage subpopulations contribute to the proinflammatory and senescent traits of old SKM.
Wed Oct 19 00:00:00 UTC 2022
Single-cell transcriptome profiling of the immune space-time landscape reveals dendritic cell regulatory program in polymicrobial sepsis.
Theranostics
Yao RQ,Li ZX,Wang LX,Li YX,Zheng LY,Dong N,Wu Y,Xia ZF,Billiar TR,Ren C,Yao YM
14-5321-82 was used in Immunohistochemistry to find a conserved and potentially targetable immunoregulatory program within DCs that associates with hyperinflammation and organ dysfunction early following sepsis induction.
Fri Jul 15 00:00:00 UTC 2022
Complement activation contributes to subretinal fibrosis through the induction of epithelial-to-mesenchymal transition (EMT) in retinal pigment epithelial cells.
Journal of neuroinflammation
Llorián-Salvador M,Byrne EM,Szczepan M,Little K,Chen M,Xu H
14-5321-82 was used in Immunocytochemistry to understand whether complement activation contributes to the development of macular fibrosis and the underlying mechanisms involved.
Thu Jul 14 00:00:00 UTC 2022
Retinal Changes in Astrocytes and Müller Glia in a Mouse Model of Laser-Induced Glaucoma: A Time-Course Study.
Biomedicines
Fernández-Albarral JA,de Hoz R,Matamoros JA,Chen L,López-Cuenca I,Salobrar-García E,Sánchez-Puebla L,Ramírez JM,Triviño A,Salazar JJ,Ramírez AI
14-5321-82 was used in Immunohistochemistry to show that there is a bilateral macroglial activation maintained over time involved in the inflammatory glaucoma process in this model of glaucoma.
Tue Apr 19 00:00:00 UTC 2022
Endogenous retroviruses promote homeostatic and inflammatory responses to the microbiota.
Cell
Lima-Junior DS,Krishnamurthy SR,Bouladoux N,Collins N,Han SJ,Chen EY,Constantinides MG,Link VM,Lim AI,Enamorado M,Cataisson C,Gil L,Rao I,Farley TK,Koroleva G,Attig J,Yuspa SH,Fischbach MA,Kassiotis G,Belkaid Y
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Thu Jul 08 00:00:00 UTC 2021
Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps.
Cell
Chen B,Scurrah CR,McKinley ET,Simmons AJ,Ramirez-Solano MA,Zhu X,Markham NO,Heiser CN,Vega PN,Rolong A,Kim H,Sheng Q,Drewes JL,Zhou Y,Southard-Smith AN,Xu Y,Ro J,Jones AL,Revetta F,Berry LD,Niitsu H,Islam M,Pelka K,Hofree M,Chen JH,Sarkizova S,Ng K,Giannakis M,Boland GM,Aguirre AJ,Anderson AC,Rozenblatt-Rosen O,Regev A,Hacohen N,Kawasaki K,Sato T,Goettel JA,Grady WM,Zheng W,Washington MK,Cai Q,Sears CL,Goldenring JR,Franklin JL,Su T,Huh WJ,Vandekar S,Roland JT,Liu Q,Coffey RJ,Shrubsole MJ,Lau KS
14-5321-82 was used in Flow cytometry/Cell sorting to present a single-cell transcriptomic and imaging atlas of the two most common human colorectal polyps, conventional adenomas and serrated polyps, and their resulting CRC counterparts.
Wed Dec 22 00:00:00 UTC 2021
CHI3L1 regulates PD-L1 and anti-CHI3L1-PD-1 antibody elicits synergistic antitumor responses.
The Journal of clinical investigation
Ma B,Akosman B,Kamle S,Lee CM,He CH,Koo JS,Lee CG,Elias JA
14-5321-82 was used in Flow Cytometry to conclude that the simultaneous targeting of CHI3L1 and the PD-1/PD-L1 axis with individual and, more powerfully, with bispecific antibodies represents a promising therapy for pulmonary metastasis and progression.
Mon Nov 01 00:00:00 UTC 2021
Regionally diverse astrocyte subtypes and their heterogeneous response to EAE.
Glia
Borggrewe M,Grit C,Vainchtein ID,Brouwer N,Wesseling EM,Laman JD,Eggen BJL,Kooistra SM,Boddeke EWGM
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Immunohistochemistry
Sat May 01 00:00:00 UTC 2021
CD11b Deficiency Exacerbates Methicillin-Resistant Staphylococcus aureus-Induced Sepsis by Upregulating Inflammatory Responses of Macrophages.
Immune network
Sim H,Jeong D,Kim HI,Pak S,Thapa B,Kwon HJ,Lee K
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Thu Apr 01 00:00:00 UTC 2021
Prostaglandin E2 serves a dual role in regulating the migration of dendritic cells.
International journal of molecular medicine
Diao G,Huang J,Zheng X,Sun X,Tian M,Han J,Guo J
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Fri Jan 01 00:00:00 UTC 2021
Glial activation precedes alpha-synuclein pathology in a mouse model of Parkinson's disease.
Neuroscience research
Izco M,Blesa J,Verona G,Cooper JM,Alvarez-Erviti L
14-5321-82 was used in Immunohistochemistry to demonstrate that in the substantia nigra glial activation is an early event that precedes alpha-synuclein inclusion formation, suggesting neuroinflammation could play an important early role in the pathogenesis of PD.
Wed Sep 01 00:00:00 UTC 2021
Wip1 regulates the immunomodulatory effects of murine mesenchymal stem cells in type 1 diabetes mellitus via targeting IFN-α/BST2.
Cell death discovery
Zhou N,Liu W,Zhang W,Liu Y,Li X,Wang Y,Zheng R,Zhang Y
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Fri Oct 29 00:00:00 UTC 2021
Topical arginase inhibition decreases growth of cutaneous squamous cell carcinoma.
Scientific reports
Mittal A,Wang M,Vidyarthi A,Yanez D,Pizzurro G,Thakral D,Tracy E,Colegio OR
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Mon May 24 00:00:00 UTC 2021
Targeting Phosphatidylserine Enhances the Anti-tumor Response to Tumor-Directed Radiation Therapy in a Preclinical Model of Melanoma.
Cell reports
Budhu S,Giese R,Gupta A,Fitzgerald K,Zappasodi R,Schad S,Hirschhorn D,Campesato LF,De Henau O,Gigoux M,Liu C,Mazo G,Deng L,Barker CA,Wolchok JD,Merghoub T
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Tue Jan 12 00:00:00 UTC 2021
Transgene distribution and immune response after ultrasound delivery of rAAV9 and PHP.B to the brain in a mouse model of amyloidosis.
Molecular therapy. Methods & clinical development
Kofoed RH,Heinen S,Silburt J,Dubey S,Dibia CL,Maes M,Simpson EM,Hynynen K,Aubert I
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Immunocytochemistry
Fri Dec 10 00:00:00 UTC 2021
Transgene distribution and immune response after ultrasound delivery of rAAV9 and PHP.B to the brain in a mouse model of amyloidosis.
Molecular therapy. Methods & clinical development
Kofoed RH,Heinen S,Silburt J,Dubey S,Dibia CL,Maes M,Simpson EM,Hynynen K,Aubert I
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Immunocytochemistry
Fri Dec 10 00:00:00 UTC 2021
Systemic Inflammation Accelerates Changes in Microglial and Synaptic Markers in an Experimental Model of Chronic Neurodegeneration.
Frontiers in neuroscience
Chouhan JK,Püntener U,Booth SG,Teeling JL
14-5321-82 was used in Immunohistochemistry to investigate the alterations in microglia activation and phenotype and synaptic markers in response to a low grade, live bacterial infection., using the ME7 prion model.
Sat Jan 22 00:00:00 UTC 2022
Systemic Inflammation Accelerates Changes in Microglial and Synaptic Markers in an Experimental Model of Chronic Neurodegeneration.
Frontiers in neuroscience
Chouhan JK,Püntener U,Booth SG,Teeling JL
14-5321-82 was used in Immunohistochemistry to investigate the alterations in microglia activation and phenotype and synaptic markers in response to a low grade, live bacterial infection., using the ME7 prion model.
Sat Jan 22 00:00:00 UTC 2022
Replicative senescence dictates the emergence of disease-associated microglia and contributes to Aβ pathology.
Cell reports
Hu Y,Fryatt GL,Ghorbani M,Obst J,Menassa DA,Martin-Estebane M,Muntslag TAO,Olmos-Alonso A,Guerrero-Carrasco M,Thomas D,Cragg MS,Gomez-Nicola D
14-5321-82 was used in Immunohistochemistry to show that the early and sustained microglial proliferation seen in an AD-like model promotes replicative senescence, characterized by increased βgal activity, a senescence-associated transcriptional signature, and telomere shortening, correlating with the appearance of disease-associated microglia (DAM) and senescent microglial profiles in human post-mortem AD cases.
Tue Jun 08 00:00:00 UTC 2021
Smek1 deficiency exacerbates experimental autoimmune encephalomyelitis by activating proinflammatory microglia and suppressing the IDO1-AhR pathway.
Journal of neuroinflammation
Duan RN,Yang CL,Du T,Liu A,Wang AR,Sun WJ,Li X,Li JX,Yan CZ,Liu QJ
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Mon Jun 28 00:00:00 UTC 2021
Frequent amplification of HDAC genes and efficacy of HDAC inhibitor chidamide and PD-1 blockade combination in soft tissue sarcoma.
Journal for immunotherapy of cancer
Que Y,Zhang XL,Liu ZX,Zhao JJ,Pan QZ,Wen XZ,Xiao W,Xu BS,Hong DC,Guo TH,Shen LJ,Fan WJ,Chen HY,Weng DS,Xu HR,Zhou PH,Zhang YZ,Niu XH,Zhang X
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Mon Feb 01 00:00:00 UTC 2021
Frequent amplification of HDAC genes and efficacy of HDAC inhibitor chidamide and PD-1 blockade combination in soft tissue sarcoma.
Journal for immunotherapy of cancer
Que Y,Zhang XL,Liu ZX,Zhao JJ,Pan QZ,Wen XZ,Xiao W,Xu BS,Hong DC,Guo TH,Shen LJ,Fan WJ,Chen HY,Weng DS,Xu HR,Zhou PH,Zhang YZ,Niu XH,Zhang X
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Mon Feb 01 00:00:00 UTC 2021
Early activation of the cardiac CX3CL1/CX3CR1 axis delays β-adrenergic-induced heart failure.
Scientific reports
Flamant M,Mougenot N,Balse E,Le Fèvre L,Atassi F,Gautier EL,Le Goff W,Keck M,Nadaud S,Combadière C,Boissonnas A,Pavoine C
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Thu Sep 09 00:00:00 UTC 2021
PP2Cδ Controls the Differentiation and Function of Dendritic Cells Through Regulating the NSD2/mTORC2/ACLY Pathway.
Frontiers in immunology
Lv N,Jin S,Liang Z,Wu X,Kang Y,Su L,Dong Y,Wang B,Ma T,Shi L
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Mon Feb 28 00:00:00 UTC 2022
Epinephrine Production in Th17 Cells and Experimental Autoimmune Encephalitis.
Frontiers in immunology
Yang P,Tian H,Zou YR,Chambon P,Ichinose H,Honig G,Diamond B,Kim SJ
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Mon Jul 05 00:00:00 UTC 2021
Epinephrine Production in Th17 Cells and Experimental Autoimmune Encephalitis.
Frontiers in immunology
Yang P,Tian H,Zou YR,Chambon P,Ichinose H,Honig G,Diamond B,Kim SJ
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Mon Jul 05 00:00:00 UTC 2021
Remote Limb Ischemic Postconditioning Protects Against Ischemic Stroke by Promoting Regulatory T Cells Thriving.
Journal of the American Heart Association
Yu HH,Ma XT,Ma X,Chen M,Chu YH,Wu LJ,Wang W,Qin C,Tian DS
14-5321-82 was used in Immunohistochemistry to demonstrate that Remote Limb Ischemic Postconditioning protects against ischemic brain injury, at least in part by activating and maintaining the Tregs through the nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide hydrate pathway.
Tue Nov 16 00:00:00 UTC 2021
Plaque-associated myeloid cells derive from resident microglia in an Alzheimer's disease model.
The Journal of experimental medicine
Reed-Geaghan EG,Croxford AL,Becher B,Landreth GE
14-5321 was used in Immunohistochemistry to genetically label different myeloid populations and unequivocally demonstrate that plaque-associated myeloid cells in the AD brain are derived exclusively from resident microglia.
Mon Apr 06 00:00:00 UTC 2020
Glufosinate constrains synchronous and metachronous metastasis by promoting anti-tumor macrophages.
EMBO molecular medicine
Menga A,Serra M,Todisco S,Riera-Domingo C,Ammarah U,Ehling M,Palmieri EM,Di Noia MA,Gissi R,Favia M,Pierri CL,Porporato PE,Castegna A,Mazzone M
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Wed Oct 07 00:00:00 UTC 2020
Proenkephalin+ regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function.
Proceedings of the National Academy of Sciences of the United States of America
Shime H,Odanaka M,Tsuiji M,Matoba T,Imai M,Yasumizu Y,Uraki R,Minohara K,Watanabe M,Bonito AJ,Fukuyama H,Ohkura N,Sakaguchi S,Morita A,Yamazaki S
14-5321-82 was used in Flow Cytometry to report a feature of skin Treg cells expanded by ultraviolet B (UVB) exposure.
Tue Aug 25 00:00:00 UTC 2020
Uterine deficiency of high-mobility group box-1 (HMGB1) protein causes implantation defects and adverse pregnancy outcomes.
Cell death and differentiation
Aikawa S,Deng W,Liang X,Yuan J,Bartos A,Sun X,Dey SK
14-5321-81 was used in Immunocytochemistry to provide evidence that nuclear HMGB1 contributes to successful blastocyst implantation by sustaining P4-PR signaling and restricting macrophage accumulation to attenuate harmful inflammatory responses.
Fri May 01 00:00:00 UTC 2020
Exosomes derived from microglia exposed to elevated pressure amplify the neuroinflammatory response in retinal cells.
Glia
Aires ID,Ribeiro-Rodrigues T,Boia R,Catarino S,Girão H,Ambrósio AF,Santiago AR
14-5321-82 was used in Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Neutralization, Western Blot to show that exosomes derived from retinal microglia have an autocrine function and propagate the inflammatory signal in conditions of elevated pressure, contributing to retinal degeneration in glaucomatous conditions.
Tue Dec 01 00:00:00 UTC 2020
Exosomes derived from microglia exposed to elevated pressure amplify the neuroinflammatory response in retinal cells.
Glia
Aires ID,Ribeiro-Rodrigues T,Boia R,Catarino S,Girão H,Ambrósio AF,Santiago AR
14-5321-82 was used in Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Neutralization, Western Blot to show that exosomes derived from retinal microglia have an autocrine function and propagate the inflammatory signal in conditions of elevated pressure, contributing to retinal degeneration in glaucomatous conditions.
Tue Dec 01 00:00:00 UTC 2020
Astrocytes promote a protective immune response to brain Toxoplasma gondii infection via IL-33-ST2 signaling.
PLoS pathogens
Still KM,Batista SJ,O'Brien CA,Oyesola OO,Früh SP,Webb LM,Smirnov I,Kovacs MA,Cowan MN,Hayes NW,Thompson JA,Tait Wojno ED,Harris TH
14-5321-81 was used in Immunohistochemistry (Frozen) to show that IL-33 is expressed by oligodendrocytes and astrocytes during T. gondii infection, is released locally into the cerebrospinal fluid of T. gondii-infected animals, and is required for control of infection.
Thu Oct 01 00:00:00 UTC 2020
CD8 T Cells and STAT1 Signaling Are Essential Codeterminants in Protection from Polyomavirus Encephalopathy.
Journal of virology
Mockus TE,Netherby-Winslow CS,Atkins HM,Lauver MD,Jin G,Ren HM,Lukacher AE
14-5321-82 was used in Flow Cytometry to define biomarkers to stratify risk of progressive multifocal leukoencephalopathy and develop anti-JC polyomavirus interventions in patients suffering from progressive multifocal leukoencephalopathy.
Tue Mar 31 00:00:00 UTC 2020
E6‑regulated overproduction of prostaglandin E2 may inhibit migration of dendritic cells in human papillomavirus 16‑positive cervical lesions.
International journal of oncology
Huang J,Diao G,Zhang Q,Chen Y,Han J,Guo J
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Wed Apr 01 00:00:00 UTC 2020
IFN-β signalling regulates RAW 264.7 macrophage activation, cytokine production, and killing activity.
Innate immunity
Karimi Y,Giles EC,Vahedi F,Chew MV,Nham T,Loukov D,Lee AJ,Bowdish DM,Ashkar AA
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Wed Apr 01 00:00:00 UTC 2020
Dietary Glucose Consumption Promotes RALDH Activity in Small Intestinal CD103+CD11b+ Dendritic Cells.
Frontiers in immunology
Ko HJ,Hong SW,Verma R,Jung J,Lee M,Kim N,Kim D,Surh CD,Kim KS,Rudra D,Im SH
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Mon Apr 19 00:00:00 UTC 2021
GDF3 Protects Mice against Sepsis-Induced Cardiac Dysfunction and Mortality by Suppression of Macrophage Pro-Inflammatory Phenotype.
Cells
Wang L,Li Y,Wang X,Wang P,Essandoh K,Cui S,Huang W,Mu X,Liu Z,Wang Y,Peng T,Fan GC
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Fri Jan 03 00:00:00 UTC 2020
Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells.
Nature communications
Lucas B,White AJ,Cosway EJ,Parnell SM,James KD,Jones ND,Ohigashi I,Takahama Y,Jenkinson WE,Anderson G
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Mon May 04 00:00:00 UTC 2020
Smooth muscle-derived progenitor cell myofibroblast differentiation through KLF4 downregulation promotes arterial remodeling and fibrosis.
JCI insight
Lu S,Jolly AJ,Strand KA,Dubner AM,Mutryn MF,Moulton KS,Nemenoff RA,Majesky MW,Weiser-Evans MC
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Thu Dec 03 00:00:00 UTC 2020
Hyaluronan Degradation by Cemip Regulates Host Defense against Staphylococcus aureus Skin Infection.
Cell reports
Dokoshi T,Zhang LJ,Li F,Nakatsuji T,Butcher A,Yoshida H,Shimoda M,Okada Y,Gallo RL
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Tue Jan 07 00:00:00 UTC 2020
Ly6cLo non-classical monocytes promote resolution of rhesus rotavirus-mediated perinatal hepatic inflammation.
Scientific reports
Alkhani A,Levy CS,Tsui M,Rosenberg KA,Polovina K,Mattis AN,Mack M,Van Dyken S,Wang BM,Maher JJ,Nijagal A
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Tue Apr 28 00:00:00 UTC 2020
MiR-103 protects from recurrent spontaneous abortion via inhibiting STAT1 mediated M1 macrophage polarization.
International journal of biological sciences
Zhu X,Liu H,Zhang Z,Wei R,Zhou X,Wang Z,Zhao L,Guo Q,Zhang Y,Chu C,Wang L,Li X
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Fri Nov 12 00:00:00 UTC 2021
Cancer cell-intrinsic expression of MHC II in lung cancer cell lines is actively restricted by MEK/ERK signaling and epigenetic mechanisms.
Journal for immunotherapy of cancer
Neuwelt AJ,Kimball AK,Johnson AM,Arnold BW,Bullock BL,Kaspar RE,Kleczko EK,Kwak JW,Wu MH,Heasley LE,Doebele RC,Li HY,Nemenoff RA,Clambey ET
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Wed Apr 01 00:00:00 UTC 2020
Immunomodulatory Effects of Recombinant Mycobacterium smegmatis Expressing Antigen-85B Epitopes in Infected J774A.1 Murine Macrophages.
Pathogens (Basel, Switzerland)
Kadir NA,Acosta A,Sarmiento ME,Norazmi MN
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Sun Nov 29 00:00:00 UTC 2020
Artificial Mini Dendritic Cells Boost T Cell-Based Immunotherapy for Ovarian Cancer.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Cheng S,Xu C,Jin Y,Li Y,Zhong C,Ma J,Yang J,Zhang N,Li Y,Wang C,Yang Z,Wang Y
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Wed Apr 01 00:00:00 UTC 2020
Optimized Protocol for Isolation of Small Extracellular Vesicles from Human and Murine Lymphoid Tissues.
International journal of molecular sciences
Bordas M,Genard G,Ohl S,Nessling M,Richter K,Roider T,Dietrich S,Maaß KK,Seiffert M
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Tue Aug 04 00:00:00 UTC 2020
Skeletal muscle healing by M1-like macrophages produced by transient expression of exogenous GM-CSF.
Stem cell research & therapy
Martins L,Gallo CC,Honda TSB,Alves PT,Stilhano RS,Rosa DS,Koh TJ,Han SW
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Fri Nov 06 00:00:00 UTC 2020
Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine.
Nature communications
Campesato LF,Budhu S,Tchaicha J,Weng CH,Gigoux M,Cohen IJ,Redmond D,Mangarin L,Pourpe S,Liu C,Zappasodi R,Zamarin D,Cavanaugh J,Castro AC,Manfredi MG,McGovern K,Merghoub T,Wolchok JD
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Tue Aug 11 00:00:00 UTC 2020
Reduction of the RNA Binding Protein TIA1 Exacerbates Neuroinflammation in Tauopathy.
Frontiers in neuroscience
LeBlang CJ,Medalla M,Nicoletti NW,Hays EC,Zhao J,Shattuck J,Cruz AL,Wolozin B,Luebke JI
14-5321 was used in Immunohistochemistry to demonstrate that TIA1 plays an important role in the neuroimmune response to chronic stress in the form of tauopathy.
Fri Nov 03 00:00:00 UTC 2023
Lactobacillus reuteri 5454 and Bifidobacterium animalis ssp. lactis 5764 improve colitis while differentially impacting dendritic cells maturation and antimicrobial responses.
Scientific reports
Hrdý J,Alard J,Couturier-Maillard A,Boulard O,Boutillier D,Delacre M,Lapadatescu C,Cesaro A,Blanc P,Pot B,Ryffel B,Chamaillard M,Grangette C
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Tue Mar 24 00:00:00 UTC 2020
Nuclear imaging-guided PD-L1 blockade therapy increases effectiveness of cancer immunotherapy.
Journal for immunotherapy of cancer
Gao H,Wu Y,Shi J,Zhang X,Liu T,Hu B,Jia B,Wan Y,Liu Z,Wang F
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Sun Nov 01 00:00:00 UTC 2020
Analysis of Myeloid Cells in Mouse Tissues with Flow Cytometry.
STAR protocols
Liu Z,Gu Y,Shin A,Zhang S,Ginhoux F
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Fri Jun 19 00:00:00 UTC 2020
RON Expression Mediates Lipopolysaccharide-Mediated Dendritic Cell Maturation via March-I.
Frontiers in cellular and infection microbiology
Huang L,Fang X,Zhang X,Wu W,Yao H,Fang Q
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Immunoprecipitation
Sun Apr 02 00:00:00 UTC 2023
RON Expression Mediates Lipopolysaccharide-Mediated Dendritic Cell Maturation via March-I.
Frontiers in cellular and infection microbiology
Huang L,Fang X,Zhang X,Wu W,Yao H,Fang Q
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Immunoprecipitation
Sun Apr 02 00:00:00 UTC 2023
Regorafenib combined with PD1 blockade increases CD8 T-cell infiltration by inducing CXCL10 expression in hepatocellular carcinoma.
Journal for immunotherapy of cancer
Shigeta K,Matsui A,Kikuchi H,Klein S,Mamessier E,Chen IX,Aoki S,Kitahara S,Inoue K,Shigeta A,Hato T,Ramjiawan RR,Staiculescu D,Zopf D,Fiebig L,Hobbs GS,Quaas A,Dima S,Popescu I,Huang P,Munn LL,Cobbold M,Goyal L,Zhu AX,Jain RK,Duda DG
14-5321-82 was used in Flow Cytometry to conclude that judicious regorafenib/anti-PD1 combination therapy can inhibit tumor growth and increase survival by normalizing tumor vasculature and increasing intratumoral CXCR3+CD8 T-cell infiltration through elevated CXCL10 expression in HCC cells.
Sun Nov 01 00:00:00 UTC 2020
Distinct Roles for Rac1 in Sertoli Cell Function during Testicular Development and Spermatogenesis.
Cell reports
Heinrich A,Potter SJ,Guo L,Ratner N,DeFalco T
14-5321 was used in Immunohistochemistry-immunofluorescence to indicate that Sertoli Rac1 function is required only for certain aspects of spermatogenesis and reveal that there are distinct requirements for cell polarity during cellular differentiation.
Tue Apr 14 00:00:00 UTC 2020
CDK4/6 inhibition promotes immune infiltration in ovarian cancer and synergizes with PD-1 blockade in a B cell-dependent manner.
Theranostics
Zhang QF,Li J,Jiang K,Wang R,Ge JL,Yang H,Liu SJ,Jia LT,Wang L,Chen BL
14-5321 was used in Flow cytometry/Cell sorting to study the efficacy of PD-1 anti-tumour therapy when combined with abemaciclib, a CDK4/6 inhibitor.
Tue Jun 01 00:00:00 UTC 2021
CDK4/6 inhibition promotes immune infiltration in ovarian cancer and synergizes with PD-1 blockade in a B cell-dependent manner.
Theranostics
Zhang QF,Li J,Jiang K,Wang R,Ge JL,Yang H,Liu SJ,Jia LT,Wang L,Chen BL
14-5321 was used in Flow cytometry/Cell sorting to study the efficacy of PD-1 anti-tumour therapy when combined with abemaciclib, a CDK4/6 inhibitor.
Tue Jun 01 00:00:00 UTC 2021
Tregitopes regulate the tolerogenic immune response and decrease the foetal death rate in abortion-prone mouse matings.
Scientific reports
Kedzierska AE,Lorek D,Slawek A,Chelmonska-Soyta A
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Mon Jun 29 00:00:00 UTC 2020
Polyanhydride Nanoparticles Induce Low Inflammatory Dendritic Cell Activation Resulting in CD8+ T Cell Memory and Delayed Tumor Progression.
International journal of nanomedicine
Darling R,Senapati S,Christiansen J,Liu L,Ramer-Tait AE,Narasimhan B,Wannemuehler M
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Mon Dec 07 00:00:00 UTC 2020
cGAS/STING axis mediates a topoisomerase II inhibitor-induced tumor immunogenicity.
The Journal of clinical investigation
Wang Z,Chen J,Hu J,Zhang H,Xu F,He W,Wang X,Li M,Lu W,Zeng G,Zhou P,Huang P,Chen S,Li W,Xia LP,Xia X
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Tue Aug 13 00:00:00 UTC 2019
Antigen-presenting ILC3 regulate T cell-dependent IgA responses to colonic mucosal bacteria.
The Journal of experimental medicine
Melo-Gonzalez F,Kammoun H,Evren E,Dutton EE,Papadopoulou M,Bradford BM,Tanes C,Fardus-Reid F,Swann JR,Bittinger K,Mabbott NA,Vallance BA,Willinger T,Withers DR,Hepworth MR
14-5321-82 was used in Flow Cytometry to study the mechanisms that modulate the magnitude and quality of T cell-dependent IgA responses.
Mon Apr 01 00:00:00 UTC 2019
Localized Treatment with Oncolytic Adenovirus Delta-24-RGDOX Induces Systemic Immunity against Disseminated Subcutaneous and Intracranial Melanomas.
Clinical cancer research : an official journal of the American Association for Cancer Research
Jiang H,Shin DH,Nguyen TT,Fueyo J,Fan X,Henry V,Carrillo CC,Yi Y,Alonso MM,Collier TL,Yuan Y,Lang FF,Gomez-Manzano C
14-5321 was used in Flow cytometry/Cell sorting to show that localized intratumoral injection of Delta-24-RGDOX induces an in situ antovaccination of the treated melanoma, the effect of which changes the immune landscape of the treated mice, resulting in systemic immunity against disseminated s.c. and i.c. tumors.
Fri Nov 15 00:00:00 UTC 2019
Forkhead transcription factor FOXO3a mediates interferon-γ-induced MHC II transcription in macrophages.
Immunology
Wu X,Fan Z,Chen M,Chen Y,Rong D,Cui Z,Yuan Y,Zhuo L,Xu Y
14-5321-82 was used in Western Blotting to investigate the role of the forkhead transcription factor FOXO3a in IFN- γ-induced MHC II transcription in macrophages.
Sun Dec 01 00:00:00 UTC 2019
Genetically induced brain inflammation by Cnp deletion transiently benefits from microglia depletion.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Garcia-Agudo LF,Janova H,Sendler LE,Arinrad S,Steixner AA,Hassouna I,Balmuth E,Ronnenberg A,Schopf N,van der Flier FJ,Begemann M,Martens H,Weber MS,Boretius S,Nave KA,Ehrenreich H
14-5321 was used in Immunohistochemistry to conclude that even though microglia depletion is temporarily beneficial and worth pursuing, complementary treatment strategies are needed for full and lasting recovery.
Mon Jul 01 00:00:00 UTC 2019
Antiallodynic Effects of Cannabinoid Receptor 2 (CB2R) Agonists on Retrovirus Infection-Induced Neuropathic Pain.
Pain research & management
Sheng WS,Chauhan P,Hu S,Prasad S,Lokensgard JR
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Mon Dec 16 00:00:00 UTC 2019
Intravitreal injection of adenosine A2A receptor antagonist reduces neuroinflammation, vascular leakage and cell death in the retina of diabetic mice.
Scientific reports
Aires ID,Madeira MH,Boia R,Rodrigues-Neves AC,Martins JM,Ambrósio AF,Santiago AR
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Immunohistochemistry
Wed Nov 20 00:00:00 UTC 2019
MDM2 inhibitor APG-115 synergizes with PD-1 blockade through enhancing antitumor immunity in the tumor microenvironment.
Journal for immunotherapy of cancer
Fang DD,Tang Q,Kong Y,Wang Q,Gu J,Fang X,Zou P,Rong T,Wang J,Yang D,Zhai Y
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Thu Nov 28 00:00:00 UTC 2019
Sequential Sensing by TLR2 and Mincle Directs Immature Myeloid Cells to Protect against Invasive Group A Streptococcal Infection in Mice.
Cell reports
Matsumura T,Ikebe T,Arikawa K,Hosokawa M,Aiko M,Iguchi A,Togashi I,Kai S,Ohara S,Ohara N,Ohnishi M,Watanabe H,Kobayashi K,Takeyama H,Yamasaki S,Takahashi Y,Ato M
14-5321-82 was used in Flow Cytometry to show IFN-γ-producing immature myeloid cells can provide protection to mice in invasive group A Streptococcus infection.
Tue Apr 09 00:00:00 UTC 2019
Discrete viral E2 lysine residues and scavenger receptor MARCO are required for clearance of circulating alphaviruses.
eLife
Carpentier KS,Davenport BJ,Haist KC,McCarthy MK,May NA,Robison A,Ruckert C,Ebel GD,Morrison TE
14-5321-82 was used in Flow Cytometry to reveal a previously unrecognized innate immune pathway that controls alphavirus viremia and dissemination in vertebrate hosts, ultimately influencing disease severity and likely transmission efficiency.
Wed Oct 09 00:00:00 UTC 2019
Cryoprotectant enables structural control of porous scaffolds for exploration of cellular mechano-responsiveness in 3D.
Nature communications
Jiang S,Lyu C,Zhao P,Li W,Kong W,Huang C,Genin GM,Du Y
14-5321-82 was used in Immunocytochemistry to discover the regulatory effect of cryoprotectants on ice crystal growth and use this property to realise separate control of the scaffold pore size and stiffness.
Fri Aug 02 00:00:00 UTC 2019
Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells.
Oncoimmunology
Salerno F,Guislain A,Freen-Van Heeren JJ,Nicolet BP,Young HA,Wolkers MC
14-5321 was used in Flow cytometry/Cell sorting to conclude that post-transcriptional mechanisms could be modulated to potentiate effective T cell therapies in cancer.
Tue Jan 12 00:00:00 UTC 2021
IL-21 Controls ILC3 Cytokine Production and Promotes a Protective Phenotype in a Mouse Model of Colitis.
ImmunoHorizons
Poholek CH,Dulson SJ,Zajac AJ,Harrington LE
14-5321 was used in Flow cytometry/Cell sorting to reveal a novel role for IL-21 in shaping innate lymphoid cell responses in the intestine and provide one mechanism by which effector CD4 T cells can influence innate immunity.
Tue Jun 04 00:00:00 UTC 2019
Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.
Cell
Gaya M,Barral P,Burbage M,Aggarwal S,Montaner B,Warren Navia A,Aid M,Tsui C,Maldonado P,Nair U,Ghneim K,Fallon PG,Sekaly RP,Barouch DH,Shalek AK,Bruckbauer A,Strid J,Batista FD
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Thu Jan 25 00:00:00 UTC 2018
Rapid chromatin repression by Aire provides precise control of immune tolerance.
Nature immunology
Koh AS,Miller EL,Buenrostro JD,Moskowitz DM,Wang J,Greenleaf WJ,Chang HY,Crabtree GR
14-5321 was used in Flow cytometry/Cell sorting to demonstrate that Brg1 and Aire fine-tune the expression of tissue-specific genes at levels that prevent toxicity yet promote immune tolerance.
Thu Feb 01 00:00:00 UTC 2018
Macrophage-specific MHCII expression is regulated by a remote Ciita enhancer controlled by NFAT5.
The Journal of experimental medicine
Buxadé M,Huerga Encabo H,Riera-Borrull M,Quintana-Gallardo L,López-Cotarelo P,Tellechea M,Martínez-Martínez S,Redondo JM,Martín-Caballero J,Flores JM,Bosch E,Rodríguez-Fernández JL,Aramburu J,López-Rodríguez C
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Mon Nov 05 00:00:00 UTC 2018
Epidermal γδ T cells originate from yolk sac hematopoiesis and clonally self-renew in the adult.
The Journal of experimental medicine
Gentek R,Ghigo C,Hoeffel G,Jorquera A,Msallam R,Wienert S,Klauschen F,Ginhoux F,Bajénoff M
14-5321 was used in Flow cytometry/Cell sorting to investigate the homeostatic maintenance mechanism and hematopoietic origin of dendritic epidermal T cells, for comparison with that of Langerhans cells in the murine epidermis.
Mon Dec 03 00:00:00 UTC 2018
The E3 ligase VHL controls alveolar macrophage function via metabolic-epigenetic regulation.
The Journal of experimental medicine
Zhang W,Li Q,Li D,Li J,Aki D,Liu YC
14-5321 was used in Flow cytometry/Cell sorting to show VHL regulates alveolar macrophages and acts as a crucial egulatory factor in lung inflammation and fibrosis.
Mon Dec 03 00:00:00 UTC 2018
IL-7-dependent maintenance of ILC3s is required for normal entry of lymphocytes into lymph nodes.
The Journal of experimental medicine
Yang J,Cornelissen F,Papazian N,Reijmers RM,Llorian M,Cupedo T,Coles M,Seddon B
14-5321 was used in Flow cytometry/Cell sorting to investigate whether continued IL-7 expression was required for the maintenance of fully developed, adult lymph nodes.
Mon Apr 02 00:00:00 UTC 2018
Tamm-Horsfall Protein Regulates Mononuclear Phagocytes in the Kidney.
Journal of the American Society of Nephrology : JASN
Micanovic R,Khan S,Janosevic D,Lee ME,Hato T,Srour EF,Winfree S,Ghosh J,Tong Y,Rice SE,Dagher PC,Wu XR,El-Achkar TM
14-5321-82 was used in Immunohistochemistry to suggest that interstitial THP positively regulates mononuclear phagocyte number, plasticity, and phagocytic activity.
Thu Mar 01 00:00:00 UTC 2018
Tumor-associated neutrophils suppress pro-tumoral IL-17+ γδ T cells through induction of oxidative stress.
PLoS biology
Mensurado S,Rei M,Lança T,Ioannou M,Gonçalves-Sousa N,Kubo H,Malissen M,Papayannopoulos V,Serre K,Silva-Santos B
14-5321 was used in Flow cytometry/Cell sorting to study the role of tumour-associated neutrophils in the regulation of γδ17 T-cell responses in the tumour microenvironment.
Tue May 01 00:00:00 UTC 2018
Functional antagonism of sphingosine-1-phosphate receptor 1 prevents cuprizone-induced demyelination.
Glia
Kim S,Bielawski J,Yang H,Kong Y,Zhou B,Li J
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Immunocytochemistry
Thu Mar 01 00:00:00 UTC 2018
Functional antagonism of sphingosine-1-phosphate receptor 1 prevents cuprizone-induced demyelination.
Glia
Kim S,Bielawski J,Yang H,Kong Y,Zhou B,Li J
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Immunocytochemistry
Thu Mar 01 00:00:00 UTC 2018
Increased Microglial Activity, Impaired Adult Hippocampal Neurogenesis, and Depressive-like Behavior in Microglial VPS35-Depleted Mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Appel JR,Ye S,Tang F,Sun D,Zhang H,Mei L,Xiong WC
14-5321-82 was used in Western Blot to identify an important role of microglial VPS35 in suppressing microglial activation and promoting hippocampal neurogenesis, which are both processes involved in AD pathogenesis.
Wed Jun 27 00:00:00 UTC 2018
Age Influences Microglial Activation After Cuprizone-Induced Demyelination.
Frontiers in aging neuroscience
Klein B,Mrowetz H,Barker CM,Lange S,Rivera FJ,Aigner L
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Immunofluorescence
Thu Oct 01 00:00:00 UTC 2020
FACS isolation of live mouse eosinophils at high purity via a protocol that does not target Siglec F.
Journal of immunological methods
Geslewitz WE,Percopo CM,Rosenberg HF
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Thu Mar 01 00:00:00 UTC 2018
Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation.
Nature communications
Bonacina F,Coe D,Wang G,Longhi MP,Baragetti A,Moregola A,Garlaschelli K,Uboldi P,Pellegatta F,Grigore L,Da Dalt L,Annoni A,Gregori S,Xiao Q,Caruso D,Mitro N,Catapano AL,Marelli-Berg FM,Norata GD
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Mon Aug 06 00:00:00 UTC 2018
CD4+ T cells are activated in regional lymph nodes and migrate to skin to initiate lymphedema.
Nature communications
García Nores GD,Ly CL,Cuzzone DA,Kataru RP,Hespe GE,Torrisi JS,Huang JJ,Gardenier JC,Savetsky IL,Nitti MD,Yu JZ,Rehal S,Mehrara BJ
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Thu May 17 00:00:00 UTC 2018
Lin-CCR2+ hematopoietic stem and progenitor cells overcome resistance to PD-1 blockade.
Nature communications
Flores CT,Wildes TJ,Drake JA,Moore GL,Dean BD,Abraham RS,Mitchell DA
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Wed Oct 17 00:00:00 UTC 2018
Embryonic macrophages and microglia ablation alter the development of dorsal root ganglion sensory neurons in mouse embryos.
Glia
Angelim MKSC,Maia LMSS,Mouffle C,Ginhoux F,Low D,Amancio-Dos-Santos A,Makhoul J,Le Corronc H,Mangin JM,Legendre P
14-5321-82 was used in Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Neutralization, Western Blot to investigate the effects of embryonic macrophage ablation on dorsal root ganglion sensory neurons.
Thu Nov 01 00:00:00 UTC 2018
PDL2+ CD11b+ dermal dendritic cells capture topical antigen through hair follicles to prime LAP+ Tregs.
Nature communications
Tordesillas L,Lozano-Ojalvo D,Dunkin D,Mondoulet L,Agudo J,Merad M,Sampson HA,Berin MC
14-5321 was used in Functional assays to show how topical antigen is acquired and presented by dendritic cells in the skin.
Fri Dec 07 00:00:00 UTC 2018
Functional characterization of oxazolone-induced colitis and survival improvement by vagus nerve stimulation.
PloS one
Meroni E,Stakenborg N,Gomez-Pinilla PJ,De Hertogh G,Goverse G,Matteoli G,Verheijden S,Boeckxstaens GE
14-5321-82 was used in Flow Cytometry to characterise the immune response in oxazolone-induced colitis and study the therapeutic effect of vagus nerve stimulation.
Tue Nov 27 00:00:00 UTC 2018
Targeting of the class II transactivator attenuates inflammation and neurodegeneration in an alpha-synuclein model of Parkinson's disease.
Journal of neuroinflammation
Williams GP,Schonhoff AM,Jurkuvenaite A,Thome AD,Standaert DG,Harms AS
14-5321 was used in Flow cytometry/Cell sorting to investigate whether genetic knockout or RNA silencing of the class II transactivator, a transcriptional co-activator required for MHCII induction, is effective in reducing the neuroinflammation and neurodegeneration observed in an α-syn mouse model of Parkinson's disease.
Thu Aug 30 00:00:00 UTC 2018
Targeting of the class II transactivator attenuates inflammation and neurodegeneration in an alpha-synuclein model of Parkinson's disease.
Journal of neuroinflammation
Williams GP,Schonhoff AM,Jurkuvenaite A,Thome AD,Standaert DG,Harms AS
14-5321 was used in Flow cytometry/Cell sorting to investigate whether genetic knockout or RNA silencing of the class II transactivator, a transcriptional co-activator required for MHCII induction, is effective in reducing the neuroinflammation and neurodegeneration observed in an α-syn mouse model of Parkinson's disease.
Thu Aug 30 00:00:00 UTC 2018
Gene Expression Profiling of Lacrimal Glands Identifies the Ectopic Expression of MHC II on Glandular Cells as a Presymptomatic Feature in a Mouse Model of Primary Sjögren's Syndrome.
Frontiers in immunology
Yin J,Zheng J,Deng F,Zhao W,Chen Y,Huang Q,Huang R,Wen L,Yue X,Petersen F,Yu X
14-5321-81 was used in Immunohistochemistry (Frozen) to identify the presymptomatic features of this novel mouse model of pSS.
Thu Oct 03 00:00:00 UTC 2019
Hyaluronan Receptor LYVE-1-Expressing Macrophages Maintain Arterial Tone through Hyaluronan-Mediated Regulation of Smooth Muscle Cell Collagen.
Immunity
Lim HY,Lim SY,Tan CK,Thiam CH,Goh CC,Carbajo D,Chew SHS,See P,Chakarov S,Wang XN,Lim LH,Johnson LA,Lum J,Fong CY,Bongso A,Biswas A,Goh C,Evrard M,Yeo KP,Basu R,Wang JK,Tan Y,Jain R,Tikoo S,Choong C,Weninger W,Poidinger M,Stanley RE,Collin M,Tan NS,Ng LG,Jackson DG,Ginhoux F,Angeli V
14-5321-82 was used in Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Neutralization, Western Blot to unveil a hitherto unknown homeostatic contribution of arterial LYVE-1+ macrophages through the control of collagen production by SMCs and has identified a function of LYVE-1 in leukocytes.
Tue Aug 21 00:00:00 UTC 2018
Hyaluronan Receptor LYVE-1-Expressing Macrophages Maintain Arterial Tone through Hyaluronan-Mediated Regulation of Smooth Muscle Cell Collagen.
Immunity
Lim HY,Lim SY,Tan CK,Thiam CH,Goh CC,Carbajo D,Chew SHS,See P,Chakarov S,Wang XN,Lim LH,Johnson LA,Lum J,Fong CY,Bongso A,Biswas A,Goh C,Evrard M,Yeo KP,Basu R,Wang JK,Tan Y,Jain R,Tikoo S,Choong C,Weninger W,Poidinger M,Stanley RE,Collin M,Tan NS,Ng LG,Jackson DG,Ginhoux F,Angeli V
14-5321-82 was used in Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Neutralization, Western Blot to unveil a hitherto unknown homeostatic contribution of arterial LYVE-1+ macrophages through the control of collagen production by SMCs and has identified a function of LYVE-1 in leukocytes.
Tue Aug 21 00:00:00 UTC 2018
Progressive striatonigral degeneration in a transgenic mouse model of multiple system atrophy: translational implications for interventional therapies.
Acta neuropathologica communications
Refolo V,Bez F,Polissidis A,Kuzdas-Wood D,Sturm E,Kamaratou M,Poewe W,Stefanis L,Angela Cenci M,Romero-Ramos M,Wenning GK,Stefanova N
14-5321 was used in Immunohistochemistry to validate a model, which provides a relevant tool for preclinical therapeutic target discovery for human Parkinson-variant multiple system atrophy.
Wed Jan 03 00:00:00 UTC 2018
Targeted intracerebral delivery of the anti-inflammatory cytokine IL13 promotes alternative activation of both microglia and macrophages after stroke.
Journal of neuroinflammation
Hamzei Taj S,Le Blon D,Hoornaert C,Daans J,Quarta A,Praet J,Van der Linden A,Ponsaerts P,Hoehn M
14-5321 was used in Immunofluorescence in immunohistochemistry on frozen tissues to investigate whether targeted intracerebral delivery of IL-13 can promote a phenotypic switch in both microglia and macrophages during the pro-inflammatory phase in a mouse model of ischaemic stroke.
Mon Jun 04 00:00:00 UTC 2018
B lymphocytes can be activated to act as antigen presenting cells to promote anti-tumor responses.
PloS one
Rossetti RAM,Lorenzi NPC,Yokochi K,Rosa MBSF,Benevides L,Margarido PFR,Baracat EC,Carvalho JP,Villa LL,Lepique AP
14-5321 was used in Flow cytometry/Cell sorting to suggest that B lymphocytes may be used as a tool for immunotherapy against cancer.
Wed Dec 26 00:00:00 UTC 2018
A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer.
The Journal of clinical investigation
Berlato C,Khan MN,Schioppa T,Thompson R,Maniati E,Montfort A,Jangani M,Canosa M,Kulbe H,Hagemann UB,Duncan AR,Fletcher L,Wilkinson RW,Powles T,Quezada SA,Balkwill FR
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Wed Mar 01 00:00:00 UTC 2017
Mast cells acquire MHCII from dendritic cells during skin inflammation.
The Journal of experimental medicine
Dudeck J,Medyukhina A,Fröbel J,Svensson CM,Kotrba J,Gerlach M,Gradtke AC,Schröder B,Speier S,Figge MT,Dudeck A
14-5321 was used in Flow cytometry/Cell sorting to identify an innate intercellular communication arming resident mast cells with key dendritic cell(DC) functions that might contribute to the acute defence potential during critical periods of migration-based DC absence.
Mon Dec 04 00:00:00 UTC 2017
TGF-β inhibitor Smad7 regulates dendritic cell-induced autoimmunity.
Proceedings of the National Academy of Sciences of the United States of America
Lukas D,Yogev N,Kel JM,Regen T,Mufazalov IA,Tang Y,Wanke F,Reizis B,Müller W,Kurschus FC,Prinz M,Kleiter I,Clausen BE,Waisman A
14-5321 was used in Flow cytometry/Cell sorting to demonstrate the role of Smad7 in the differentiation of dendritic cells in mice and their influence on the efficient function in immunity.
Tue Feb 21 00:00:00 UTC 2017
Primary Tumors Limit Metastasis Formation through Induction of IL15-Mediated Cross-Talk between Patrolling Monocytes and NK Cells.
Cancer immunology research
Kubo H,Mensurado S,Gonçalves-Sousa N,Serre K,Silva-Santos B
14-5321 was used in Flow cytometry/Cell sorting to identifies an innate cell network and the molecular determinants responsible for metastasis immunosurveillance, providing support for using the key molecular mediator to improve immunotherapeutic outcomes.
Fri Sep 01 00:00:00 UTC 2017
Prolonged Deleterious Influences of Chemotherapeutic Agent CPT-11 on Resident Peritoneal Macrophages and B1 Cells.
Frontiers in immunology
Bai WJ,Li CG,Zhang CC,Xu LH,Zeng QZ,Hu B,Hong Z,He XH,Ouyang DY
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Wed Nov 20 00:00:00 UTC 2019
Transient Depletion of CD169+ Cells Contributes to Impaired Early Protection and Effector CD8+ T Cell Recruitment against Mucosal Respiratory Syncytial Virus Infection.
Frontiers in immunology
Oh DS,Oh JE,Jung HE,Lee HK
14-5321 was used in Flow cytometry/Cell sorting to explore the roles of CD169+ cells in immune responses to mucosal respiratory syncytial virus infection.
Wed Nov 20 00:00:00 UTC 2019
Early IL-6 signalling promotes IL-27 dependent maturation of regulatory T cells in the lungs and resolution of viral immunopathology.
PLoS pathogens
Pyle CJ,Uwadiae FI,Swieboda DP,Harker JA
14-5321-82 was used in Flow Cytometry to show that during respiratory virus infection the prototypic inflammatory cytokine IL-6 is a critical anti-inflammatory regulator of viral induced immunopathology in the respiratory tract through its induction of IL-27.
Fri Sep 01 00:00:00 UTC 2017
Peripheral administration of the soluble TNF inhibitor XPro1595 modifies brain immune cell profiles, decreases beta-amyloid plaque load, and rescues impaired long-term potentiation in 5xFAD mice.
Neurobiology of disease
MacPherson KP,Sompol P,Kannarkat GT,Chang J,Sniffen L,Wildner ME,Norris CM,Tansey MG
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Thu Jun 01 00:00:00 UTC 2017
NCR1-deficiency diminishes the generation of protective murine cytomegalovirus antibodies by limiting follicular helper T-cell maturation.
European journal of immunology
Miletic A,Lenartic M,Popovic B,Brizic I,Trsan T,Miklic K,Mandelboim O,Krmpotic A,Jonjic S
14-5321 was used in Flow cytometry/Cell sorting to provide evidence for the role of NCR1 in antibody response to mouse cytomegalovirus infection.
Fri Sep 01 00:00:00 UTC 2017
Discrimination of the heterogeneity of bone marrow‑derived dendritic cells.
Molecular medicine reports
Wang J,Dai X,Hsu C,Ming C,He Y,Zhang J,Wei L,Zhou P,Wang CY,Yang J,Gong N
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Wed Nov 01 00:00:00 UTC 2017
Loss of IRF2BP2 in Microglia Increases Inflammation and Functional Deficits after Focal Ischemic Brain Injury.
Frontiers in cellular neuroscience
Cruz SA,Hari A,Qin Z,Couture P,Huang H,Lagace DC,Stewart AFR,Chen HH
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Thu Mar 17 00:00:00 UTC 2022
Role of a novel immune modulating DDR2-expressing population in silica-induced pulmonary fibrosis.
PloS one
McDonald LT,Johnson SD,Russell DL,Young MRI,LaRue AC
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Mon Sep 25 00:00:00 UTC 2017
Heavy Chain-Hyaluronan/Pentraxin 3 from Amniotic Membrane Suppresses Inflammation and Scarring in Murine Lacrimal Gland and Conjunctiva of Chronic Graft-versus-Host Disease.
Scientific reports
Ogawa Y,He H,Mukai S,Imada T,Nakamura S,Su CW,Mahabole M,Tseng SC,Tsubota K
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Immunofluorescence
Mon Feb 06 00:00:00 UTC 2017
Functional characterization of the lysosomal membrane protein TMEM192 in mice.
Oncotarget
Nguyen TL,Schneppenheim J,Rudnik S,Lüllmann-Rauch R,Bernreuther C,Hermans-Borgmeyer I,Glatzel M,Saftig P,Schröder B
14-5321-82 was used in Flow Cytometry to conclude that under basal conditions in vivo the loss of TMEM192 can be efficiently compensated by alternative pathways.
Tue Jul 04 00:00:00 UTC 2017
Intrapancreatic injection of human bone marrow-derived mesenchymal stem/stromal cells alleviates hyperglycemia and modulates the macrophage state in streptozotocin-induced type 1 diabetic mice.
PloS one
Murai N,Ohtaki H,Watanabe J,Xu Z,Sasaki S,Yagura K,Shioda S,Nagasaka S,Honda K,Izumizaki M
14-5321 was used in Immunohistochemistry to evaluate the effects of intrapancreatic and intravenous injection of human BMMSCs in streptozotocin-induced type-1 diabetic mouse model.
Mon Nov 20 00:00:00 UTC 2017
H9N2 Avian Influenza Virus Protein PB1 Enhances the Immune Responses of Bone Marrow-Derived Dendritic Cells by Down-Regulating miR375.
Frontiers in microbiology
Lin J,Xia J,Tu CZ,Zhang KY,Zeng Y,Yang Q
14-5321 was used in Flow cytometry/Cell sorting to shed new light on the roles and mechanisms of PB1 and miR375 in regulating DC function and suggest new strategies for combating AIV.
Wed Sep 30 00:00:00 UTC 2020
CD40-signalling abrogates induction of RORγt+ Treg cells by intestinal CD103+ DCs and causes fatal colitis.
Nature communications
Barthels C,Ogrinc A,Steyer V,Meier S,Simon F,Wimmer M,Blutke A,Straub T,Zimber-Strobl U,Lutgens E,Marconi P,Ohnmacht C,Garzetti D,Stecher B,Brocker T
14532182 was used in flow cytometry to report a CD40-dependent mechanism capable of abrogating inducible T regulatory cell induction by dendritic cells
Thu Mar 09 00:00:00 UTC 2017
Eicosapentaenoic acid and 5-HEPE enhance macrophage-mediated Treg induction in mice.
Scientific reports
Onodera T,Fukuhara A,Shin J,Hayakawa T,Otsuki M,Shimomura I
14-5321 was used in Flow cytometry/Cell sorting to demonstrate that both EPA and 5-HEPE enhance ATM-mediated Treg induction.
Tue Jul 04 00:00:00 UTC 2017
CD4+ and CD8+ T cells are both needed to induce paraneoplastic neurological disease in a mouse model.
Oncoimmunology
Gebauer C,Pignolet B,Yshii L,Mauré E,Bauer J,Liblau R
14-5321 was used in Flow cytometry/Cell sorting to provide further insight into the cellular mechanisms whereby a potent anti-tumor immunity triggers a cancer-associated autoimmune disease, and may therefore help to develop new therapeutic strategies against PND.
Tue Jan 12 00:00:00 UTC 2021
α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration.
Acta neuropathologica communications
Harms AS,Delic V,Thome AD,Bryant N,Liu Z,Chandra S,Jurkuvenaite A,West AB
Tue Nov 21 00:00:00 UTC 2017
Acidic chitinase primes the protective immune response to gastrointestinal nematodes.
Nature immunology
Vannella KM,Ramalingam TR,Hart KM,de Queiroz Prado R,Sciurba J,Barron L,Borthwick LA,Smith AD,Mentink-Kane M,White S,Thompson RW,Cheever AW,Bock K,Moore I,Fitz LJ,Urban JF,Wynn TA
14-5321 was used in Flow cytometry/Cell sorting to use AMCase-deficient mice as a means to dissect the role of the enzyme in several models of helminth infection and type 2 cytokine-driven airway inflammation.
Sun May 01 00:00:00 UTC 2016
Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation.
Nature immunology
Monticelli LA,Buck MD,Flamar AL,Saenz SA,Tait Wojno ED,Yudanin NA,Osborne LC,Hepworth MR,Tran SV,Rodewald HR,Shah H,Cross JR,Diamond JM,Cantu E,Christie JD,Pearce EL,Artis D
14-5321 was used in Flow cytometry/Cell sorting to identify Arg1 as a key regulator of group 2 innate lymphoid cell bioenergetics that control proliferative capacity and pro-inflammatory functions.
Wed Jun 01 00:00:00 UTC 2016
Microglial brain region-dependent diversity and selective regional sensitivities to aging.
Nature neuroscience
Grabert K,Michoel T,Karavolos MH,Clohisey S,Baillie JK,Stevens MP,Freeman TC,Summers KM,McColl BW
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Tue Mar 01 00:00:00 UTC 2016
LYN- and AIRE-mediated tolerance checkpoint defects synergize to trigger organ-specific autoimmunity.
The Journal of clinical investigation
Proekt I,Miller CN,Jeanne M,Fasano KJ,Moon JJ,Lowell CA,Gould DB,Anderson MS,DeFranco AL
14-5321-82 was used in In vitro experiments to demonstrate how two distinct tolerance pathways can synergize to unleash organ-specific autoimmunity.
Mon Oct 03 00:00:00 UTC 2016
Microbiota regulate the ability of lung dendritic cells to induce IgA class-switch recombination and generate protective gastrointestinal immune responses.
The Journal of experimental medicine
Ruane D,Chorny A,Lee H,Faith J,Pandey G,Shan M,Simchoni N,Rahman A,Garg A,Weinstein EG,Oropallo M,Gaylord M,Ungaro R,Cunningham-Rundles C,Alexandropoulos K,Mucida D,Merad M,Cerutti A,Mehandru S
14-5321 was used in Flow cytometry/Cell sorting to demonstrate the role of the microbiota in modulating the protective efficacy of intranasal vaccination through their effect on the IgA class-switching function of lung dendritic cells.
Mon Jan 11 00:00:00 UTC 2016
Thy1+IL-7+ lymphatic endothelial cells in iBALT provide a survival niche for memory T-helper cells in allergic airway inflammation.
Proceedings of the National Academy of Sciences of the United States of America
Shinoda K,Hirahara K,Iinuma T,Ichikawa T,Suzuki AS,Sugaya K,Tumes DJ,Yamamoto H,Hara T,Tani-Ichi S,Ikuta K,Okamoto Y,Nakayama T
14-5321 was used in Immunohistochemistry on frozen tissues to investigate how pathogenic Th cells are maintained at sites of local inflammation, showing that Thy1+IL-7+ lymphatic endothelial cells in iBALT provide a survival niche.
Tue May 17 00:00:00 UTC 2016
CD11c(+) monocyte/macrophages promote chronic Helicobacter hepaticus-induced intestinal inflammation through the production of IL-23.
Mucosal immunology
Arnold IC,Mathisen S,Schulthess J,Danne C,Hegazy AN,Powrie F
14-5321 was used in Flow cytometry/Cell sorting to investigate the mechanism by which IL-23 produced by CD11c+ monocytes/macrophages promotes chronic Helicobacter hepaticus-induced intestinal inflammation.
Tue Mar 01 00:00:00 UTC 2016
Interleukin-13 immune gene therapy prevents CNS inflammation and demyelination via alternative activation of microglia and macrophages.
Glia
Guglielmetti C,Le Blon D,Santermans E,Salas-Perdomo A,Daans J,De Vocht N,Shah D,Hoornaert C,Praet J,Peerlings J,Kara F,Bigot C,Mai Z,Goossens H,Hens N,Hendrix S,Verhoye M,Planas AM,Berneman Z,van der Linden A,Ponsaerts P
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Immunofluorescence
Thu Dec 01 00:00:00 UTC 2016
Microglia are less pro-inflammatory than myeloid infiltrates in the hippocampus of mice exposed to status epilepticus.
Glia
Vinet J,Vainchtein ID,Spano C,Giordano C,Bordini D,Curia G,Dominici M,Boddeke HW,Eggen BJ,Biagini G
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Immunofluorescence
Mon Aug 01 00:00:00 UTC 2016
Opposite Effects of Coinjection and Distant Injection of Mesenchymal Stem Cells on Breast Tumor Cell Growth.
Stem cells translational medicine
Zheng H,Zou W,Shen J,Xu L,Wang S,Fu YX,Fan W
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Thu Sep 01 00:00:00 UTC 2016
IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid.
PLoS pathogens
Naujoks J,Tabeling C,Dill BD,Hoffmann C,Brown AS,Kunze M,Kempa S,Peter A,Mollenkopf HJ,Dorhoi A,Kershaw O,Gruber AD,Sander LE,Witzenrath M,Herold S,Nerlich A,Hocke AC,van Driel I,Suttorp N,Bedoui S,Hilbi H,Trost M,Opitz B
14-5321 was used in Flow cytometry/Cell sorting to explore the overall role IFNs play in inducing substantial remodeling of bacterial vacuoles and in stimulating production of IRG1-derived itaconic acid which targets intravacuolar pathogens.
Mon Feb 01 00:00:00 UTC 2016
An Epithelial Integrin Regulates the Amplitude of Protective Lung Interferon Responses against Multiple Respiratory Pathogens.
PLoS pathogens
Meliopoulos VA,Van de Velde LA,Van de Velde NC,Karlsson EA,Neale G,Vogel P,Guy C,Sharma S,Duan S,Surman SL,Jones BG,Johnson MD,Bosio C,Jolly L,Jenkins RG,Hurwitz JL,Rosch JW,Sheppard D,Thomas PG,Murray PJ,Schultz-Cherry S
14-5321 was used in Immunohistochemistry to show that upregulation of the epithelial integrin αVβ6 during influenza infection is involved in disease pathogenesis.
Mon Aug 01 00:00:00 UTC 2016
A20 Deficiency in Lung Epithelial Cells Protects against Influenza A Virus Infection.
PLoS pathogens
Maelfait J,Roose K,Vereecke L,Mc Guire C,Sze M,Schuijs MJ,Willart M,Ibañez LI,Hammad H,Lambrecht BN,Beyaert R,Saelens X,van Loo G
14-5321 was used in Flow cytometry/Cell sorting to investigate the function of A20 in club cells in antiviral immunity, showing that deficiency in A20 protects against influenza virus infection.
Fri Jan 01 00:00:00 UTC 2016
PI3Kγ Is Critical for Dendritic Cell-Mediated CD8+ T Cell Priming and Viral Clearance during Influenza Virus Infection.
PLoS pathogens
Nobs SP,Schneider C,Heer AK,Huotari J,Helenius A,Kopf M
14-5321 was used in Flow cytometry/Cell sorting to identify PI3Kγ as a novel key host protective factor in influenza virus infection.
Tue Mar 01 00:00:00 UTC 2016
microRNA-155 Regulates Alpha-Synuclein-Induced Inflammatory Responses in Models of Parkinson Disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Thome AD,Harms AS,Volpicelli-Daley LA,Standaert DG
14-5321 was used in Immunohistochemistry to suggest that miR-155 has a central role in the inflammatory response to α-syn in the brain and in α-syn-related neurodegeneration.
Wed Feb 24 00:00:00 UTC 2016
microRNA-155 Regulates Alpha-Synuclein-Induced Inflammatory Responses in Models of Parkinson Disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Thome AD,Harms AS,Volpicelli-Daley LA,Standaert DG
14-5321 was used in Immunohistochemistry to suggest that miR-155 has a central role in the inflammatory response to α-syn in the brain and in α-syn-related neurodegeneration.
Wed Feb 24 00:00:00 UTC 2016
Recruited monocytes modulate malaria-induced lung injury through CD36-mediated clearance of sequestered infected erythrocytes.
Journal of leukocyte biology
Lagassé HA,Anidi IU,Craig JM,Limjunyawong N,Poupore AK,Mitzner W,Scott AL
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Sun May 01 00:00:00 UTC 2016
Lymphatic endothelial lineage assemblage during corneal lymphangiogenesis.
Laboratory investigation; a journal of technical methods and pathology
Connor AL,Kelley PM,Tempero RM
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Immunofluorescence
Tue Mar 01 00:00:00 UTC 2016
Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.
Journal of immunology (Baltimore, Md. : 1950)
Menendez CM,Jinkins JK,Carr DJ
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Mon Aug 15 00:00:00 UTC 2016
TNF and CD28 Signaling Play Unique but Complementary Roles in the Systemic Recruitment of Innate Immune Cells after Staphylococcus aureus Enterotoxin A Inhalation.
Journal of immunology (Baltimore, Md. : 1950)
Svedova J,Tsurutani N,Liu W,Khanna KM,Vella AT
14-5321 was used in Flow cytometry/Cell sorting to investigate how Staphylococcus aureus enterotoxins spread systemically and trigger inflammatory cascades.
Wed Jun 01 00:00:00 UTC 2016
Blood Stem Cell Activity Is Arrested by Th1-Mediated Injury Preventing Engraftment following Nonmyeloablative Conditioning.
Journal of immunology (Baltimore, Md. : 1950)
Müller AM,Florek M,Kohrt HE,Küpper NJ,Filatenkov A,Linderman JA,Hadeiba H,Negrin RS,Shizuru JA
14-5321 was used in Flow cytometry/Cell sorting to shed new light on the effects of CD4+ T cells on HSC biology.
Tue Nov 15 00:00:00 UTC 2016
Effects of ketanserin on experimental colitis in mice and macrophage function.
International journal of molecular medicine
Xiao J,Shao L,Shen J,Jiang W,Feng Y,Zheng P,Liu F
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Tue Mar 01 00:00:00 UTC 2016
Repulsive guidance molecule a blockade exerts the immunoregulatory function in DCs stimulated with ABP and LPS.
Human vaccines & immunotherapeutics
Xu X,Gao Y,Zhai Z,Zhang S,Shan F,Feng J
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Tue Aug 02 00:00:00 UTC 2016
Thiol peroxiredoxin, a novel allergen from Bombyx mori, modulates functions of macrophages and dendritic cells.
American journal of translational research
Wang H,Hu W,Liang Z,Zeng L,Li J,Yan H,Yang P,Liu Z,Wang L
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Thu Oct 01 00:00:00 UTC 2020
The HPV16 E7 Oncoprotein Disrupts Dendritic Cell Function and Induces the Systemic Expansion of CD11b(+)Gr1(+) Cells in a Transgenic Mouse Model.
BioMed research international
Damian-Morales G,Serafín-Higuera N,Moreno-Eutimio MA,Cortés-Malagón EM,Bonilla-Delgado J,Rodríguez-Uribe G,Ocadiz-Delgado R,Lambert PF,Gariglio P
14-5321 was used in Immunohistochemistry to suggest that the HPV16 E7 oncoprotein impairs dendritic cell function and morphology and induces the systemic accumulation of CD11b(+)Gr1(+) cells.
Wed Feb 22 00:00:00 UTC 2017
Allergy Enhances Neurogenesis and Modulates Microglial Activation in the Hippocampus.
Frontiers in cellular neuroscience
Klein B,Mrowetz H,Thalhamer J,Scheiblhofer S,Weiss R,Aigner L
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Immunofluorescence
Fri Jul 22 00:00:00 UTC 2016
Stroke sensitivity in the aged: sex chromosome complement vs. gonadal hormones.
Aging
McCullough LD,Mirza MA,Xu Y,Bentivegna K,Steffens EB,Ritzel R,Liu F
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Fri Jul 01 00:00:00 UTC 2016
Epidermal RAF prevents allergic skin disease.
eLife
Raguz J,Jeric I,Niault T,Nowacka JD,Kuzet SE,Rupp C,Fischer I,Biggi S,Borsello T,Baccarini M
14-5321 was used in Immunohistochemistry to investigate the role of RAF in epidermal homeostasis.
Tue Jul 19 00:00:00 UTC 2016
Epidermal RAF prevents allergic skin disease.
eLife
Raguz J,Jeric I,Niault T,Nowacka JD,Kuzet SE,Rupp C,Fischer I,Biggi S,Borsello T,Baccarini M
14-5321 was used in Immunohistochemistry to investigate the role of RAF in epidermal homeostasis.
Tue Jul 19 00:00:00 UTC 2016
Intracerebral transplantation of interleukin 13-producing mesenchymal stem cells limits microgliosis, oligodendrocyte loss and demyelination in the cuprizone mouse model.
Journal of neuroinflammation
Le Blon D,Guglielmetti C,Hoornaert C,Quarta A,Daans J,Dooley D,Lemmens E,Praet J,De Vocht N,Reekmans K,Santermans E,Hens N,Goossens H,Verhoye M,Van der Linden A,Berneman Z,Hendrix S,Ponsaerts P
14-5321 was used in Immunofluorescence to investigate the behaviour of control and IL-13-expressing mesenchymal stem cell grafts under both healthy and inflammatory CNS conditions in mice.
Wed Nov 09 00:00:00 UTC 2016
Internalization and presentation of myelin antigens by the brain endothelium guides antigen-specific T cell migration.
eLife
Lopes Pinheiro MA,Kamermans A,Garcia-Vallejo JJ,van Het Hof B,Wierts L,O'Toole T,Boeve D,Verstege M,van der Pol SM,van Kooyk Y,de Vries HE,Unger WW
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Thu Jun 23 00:00:00 UTC 2016
Laser Therapy Inhibits Tumor Growth in Mice by Promoting Immune Surveillance and Vessel Normalization.
EBioMedicine
Ottaviani G,Martinelli V,Rupel K,Caronni N,Naseem A,Zandonà L,Perinetti G,Gobbo M,Di Lenarda R,Bussani R,Benvenuti F,Giacca M,Biasotto M,Zacchigna S
14-5321 was used in Flow cytometry/Cell sorting to explore the anti-cancer effect of three laser protocols in B16F10 melanoma and oral carcinogenesis mouse models.
Thu Sep 01 00:00:00 UTC 2016
Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells.
Nature communications
Göbel K,Pankratz S,Asaridou CM,Herrmann AM,Bittner S,Merker M,Ruck T,Glumm S,Langhauser F,Kraft P,Krug TF,Breuer J,Herold M,Gross CC,Beckmann D,Korb-Pap A,Schuhmann MK,Kuerten S,Mitroulis I,Ruppert C,Nolte MW,Panousis C,Klotz L,Kehrel B,Korn T,Langer HF,Pap T,Nieswandt B,Wiendl H,Chavakis T,Kleinschnitz C,Meuth SG
14-5321 was used in Flow cytometry/Cell sorting to study how immune activation by FXII is mediated by dendritic cells in a CD87-dependent manner, and involves alterations in intracellular cyclic AMP formation.
Wed May 18 00:00:00 UTC 2016
Orally administered β-glucan attenuates the Th2 response in a model of airway hypersensitivity.
SpringerPlus
Burg AR,Quigley L,Jones AV,O'Connor GM,Boelte K,McVicar DW,Orr SJ
14-5321 was used in Flow cytometry/Cell sorting to study the immunological effects of WGP containing β-1,3/1,6-glucans in a mouse model of asthma and consider its therapeutic potential.
Fri Jul 08 00:00:00 UTC 2016
Balancing intestinal and systemic inflammation through cell type-specific expression of the aryl hydrocarbon receptor repressor.
Scientific reports
Brandstätter O,Schanz O,Vorac J,König J,Mori T,Maruyama T,Korkowski M,Haarmann-Stemmann T,von Smolinski D,Schultze JL,Abel J,Esser C,Takeyama H,Weighardt H,Förster I
14-5321 was used in Flow cytometry/Cell sorting to highlight the physiologic importance of cell-type specific balancing of AhR/AhRR expression in response to microbial, nutritional and other environmental stimuli.
Tue May 17 00:00:00 UTC 2016
Phenotypic dynamics of microglial and monocyte-derived cells in glioblastoma-bearing mice.
Scientific reports
Ricard C,Tchoghandjian A,Luche H,Grenot P,Figarella-Branger D,Rougon G,Malissen M,Debarbieux F
14532182 was used in immunohistochemistry to characterize the cellular basis and dynamics of the inflammatory microenvironment present in glioblastomas multiforme
Thu May 19 00:00:00 UTC 2016
Hyperglycemia Induces Skin Barrier Dysfunctions with Impairment of Epidermal Integrity in Non-Wounded Skin of Type 1 Diabetic Mice.
PloS one
Okano J,Kojima H,Katagi M,Nakagawa T,Nakae Y,Terashima T,Kurakane T,Kubota M,Maegawa H,Udagawa J
14-5321 was used in Flow cytometry/Cell sorting to investigate whether hyperglycaemia induces skin barrier dysfunction through alterations of epidermal integrity.
Wed Jun 21 00:00:00 UTC 2017
Preclinical Development of Ipilimumab and Nivolumab Combination Immunotherapy: Mouse Tumor Models, In Vitro Functional Studies, and Cynomolgus Macaque Toxicology.
PloS one
Selby MJ,Engelhardt JJ,Johnston RJ,Lu LS,Han M,Thudium K,Yao D,Quigley M,Valle J,Wang C,Chen B,Cardarelli PM,Blanset D,Korman AJ
14-5321 was used in Flow cytometry/Cell sorting to exhibit a preclinical strategy for the identification and development of highly effective antitumour combination immunotherapies.
Fri Aug 25 00:00:00 UTC 2017
Conditions for the generation of cytotoxic CD4(+) Th cells that enhance CD8(+) CTL-mediated tumor regression.
Clinical & translational immunology
Li K,Baird M,Yang J,Jackson C,Ronchese F,Young S
14-5321 was used in Flow cytometry/Cell sorting to provide valuable data for further research into in vitro expansion of CD4(+) Th1-like cells, with potential applications to cancer treatment involving ACT.
Mon Aug 01 00:00:00 UTC 2016
Loss of the Ubiquitin-conjugating Enzyme UBE2W Results in Susceptibility to Early Postnatal Lethality and Defects in Skin, Immune, and Male Reproductive Systems.
The Journal of biological chemistry
Wang B,Merillat SA,Vincent M,Huber AK,Basrur V,Mangelberger D,Zeng L,Elenitoba-Johnson K,Miller RA,Irani DN,Dlugosz AA,Schnell S,Scaglione KM,Paulson HL
14-5321 was used in Flow cytometry/Cell sorting to establish that UBE2W is an important protein for early postnatal survival and the normal functioning of multiple organ systems.
Fri Feb 05 00:00:00 UTC 2016
SCIB2, an antibody DNA vaccine encoding NY-ESO-1 epitopes, induces potent antitumor immunity which is further enhanced by checkpoint blockade.
Oncoimmunology
Xue W,Metheringham RL,Brentville VA,Gunn B,Symonds P,Yagita H,Ramage JM,Durrant LG
14-5321 was used for blocking in Elispot assays to show that targeting NY-ESO-1 epitopes to antigen-presenting cells results in high-avidity and high-frequency T cell immune responses, with potent antitumor responses in mice.
Wed Jun 01 00:00:00 UTC 2016
Selective inhibition of the p38 alternative activation pathway in infiltrating T cells inhibits pancreatic cancer progression.
Nature medicine
Alam MS,Gaida MM,Bergmann F,Lasitschka F,Giese T,Giese NA,Hackert T,Hinz U,Hussain SP,Kozlov SV,Ashwell JD
14-5321 was used in Flow cytometry/Cell sorting to demonstrate that TCR-mediated activation of CD4+ TIL results in alternative p38 activation and production of pro-tumorigenic factors.
Sun Nov 01 00:00:00 UTC 2015
Structural and functional features of central nervous system lymphatic vessels.
Nature
Louveau A,Smirnov I,Keyes TJ,Eccles JD,Rouhani SJ,Peske JD,Derecki NC,Castle D,Mandell JW,Lee KS,Harris TH,Kipnis J
14-5321 was used in Immunohistochemistry-wholemount to investigate the mechanisms governing the entrance and exit of immune cells from the CNS.
Thu Jul 16 00:00:00 UTC 2015
Inhibition of the TNF Family Cytokine RANKL Prevents Autoimmune Inflammation in the Central Nervous System.
Immunity
Guerrini MM,Okamoto K,Komatsu N,Sawa S,Danks L,Penninger JM,Nakashima T,Takayanagi H
14-5321-82 was used in Flow Cytometry to show that receptor activator of nuclear factor-κB (NF-κB) ligand (RANKL) on T cells regulates C-C type chemokine ligand 20 (CCL20) production by astrocytes and T cell localization in the CNS.
Tue Dec 15 00:00:00 UTC 2015
Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease.
Blood
Flynn R,Allen JL,Luznik L,MacDonald KP,Paz K,Alexander KA,Vulic A,Du J,Panoskaltsis-Mortari A,Taylor PA,Poe JC,Serody JS,Murphy WJ,Hill GR,Maillard I,Koreth J,Cutler CS,Soiffer RJ,Antin JH,Ritz J,Chao NJ,Clynes RA,Sarantopoulos S,Blazar BR
14-5321 was used in Flow cytometry/Cell sorting to further evaluate the role of the spleen tyrosine kinase in graft-versus-host disease in multiple murine models and human peripheral blood cells.
Thu Jun 25 00:00:00 UTC 2015
Adaptive Immune Regulation of Mammary Postnatal Organogenesis.
Developmental cell
Plaks V,Boldajipour B,Linnemann JR,Nguyen NH,Kersten K,Wolf Y,Casbon AJ,Kong N,van den Bijgaart RJ,Sheppard D,Melton AC,Krummel MF,Werb Z
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Mon Sep 14 00:00:00 UTC 2015
Adaptive Immune Regulation of Mammary Postnatal Organogenesis.
Developmental cell
Plaks V,Boldajipour B,Linnemann JR,Nguyen NH,Kersten K,Wolf Y,Casbon AJ,Kong N,van den Bijgaart RJ,Sheppard D,Melton AC,Krummel MF,Werb Z
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Mon Sep 14 00:00:00 UTC 2015
Benefits of Neuronal Preferential Systemic Gene Therapy for Neurotransmitter Deficiency.
Molecular therapy : the journal of the American Society of Gene Therapy
Lee NC,Muramatsu S,Chien YH,Liu WS,Wang WH,Cheng CH,Hu MK,Chen PW,Tzen KY,Byrne BJ,Hwu WL
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Immunohistochemistry
Thu Oct 01 00:00:00 UTC 2015
LKB1 inhibition of NF-κB in B cells prevents T follicular helper cell differentiation and germinal center formation.
EMBO reports
Walsh NC,Waters LR,Fowler JA,Lin M,Cunningham CR,Brooks DG,Rehg JE,Morse HC,Teitell MA
14-5321 was used in Flow cytometry/Cell sorting to show that LKB1 expression in B cells maintains B-cell quiescence and prevents the premature formation of germinal centers.
Mon Jun 01 00:00:00 UTC 2015
Transcription factor c-Rel plays a crucial role in driving anti-CD40-mediated innate colitis.
Mucosal immunology
Visekruna A,Linnerz T,Martinic V,Vachharajani N,Hartmann S,Harb H,Joeris T,Pfefferle PI,Hofer MJ,Steinhoff U
14-5321 was used in Flow cytometry/Cell sorting to investigate the role c-Rel plays in regulating innate lymphoid cells which induce anti-CD40-mediated innate colitis in mice.
Sun Mar 01 00:00:00 UTC 2015
Lymph-borne CD8α+ dendritic cells are uniquely able to cross-prime CD8+ T cells with antigen acquired from intestinal epithelial cells.
Mucosal immunology
Cerovic V,Houston SA,Westlund J,Utriainen L,Davison ES,Scott CL,Bain CC,Joeris T,Agace WW,Kroczek RA,Mowat AM,Yrlid U,Milling SW
14-5321 was used in Flow cytometry/Cell sorting to investigate which intestinal phagocytes perform cross-presentation in vivo.
Thu Jan 01 00:00:00 UTC 2015
Foxm1 regulates resolution of hyperoxic lung injury in newborns.
American journal of respiratory cell and molecular biology
Xia H,Ren X,Bolte CS,Ustiyan V,Zhang Y,Shah TA,Kalin TV,Whitsett JA,Kalinichenko VV
14-5321 was used in Flow cytometry/Cell sorting to demonstrate that Foxm1 influences pulmonary inflammatory responses to hyperoxia, inhibiting neutrophil-derived enzymes and enhancing monocytic responses that limit alveolar injury and remodeling in neonatal lungs.
Fri May 01 00:00:00 UTC 2015
The late endosomal adaptor molecule p14 (LAMTOR2) regulates TGFβ1-mediated homeostasis of Langerhans cells.
The Journal of investigative dermatology
Sparber F,Tripp CH,Komenda K,Scheffler JM,Clausen BE,Huber LA,Romani N,Stoitzner P
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Thu Jan 01 00:00:00 UTC 2015
Helminth Infection and Commensal Microbiota Drive Early IL-10 Production in the Skin by CD4+ T Cells That Are Functionally Suppressive.
PLoS pathogens
Sanin DE,Prendergast CT,Bourke CD,Mountford AP
14-5321 was used in Flow cytometry/Cell sorting to investigate the role of skin CD4+ T cells in immune regulation after repeated pathogen exposure.
Fri May 01 00:00:00 UTC 2015
The neurotrophic receptor Ntrk2 directs lymphoid tissue neovascularization during Leishmania donovani infection.
PLoS pathogens
Dalton JE,Glover AC,Hoodless L,Lim EK,Beattie L,Kirby A,Kaye PM
14-5321 was used in Flow cytometry/Cell sorting to investigate how Ntrk2 plays a role in the pathologic remodeling of the spleen that accompanies chronic infection.
Sun Feb 01 00:00:00 UTC 2015
The atypical chemokine receptor ACKR2 suppresses Th17 responses to protein autoantigens.
Immunology and cell biology
Hansell CA,MacLellan LM,Oldham RS,Doonan J,Chapple KJ,Anderson EJ,Linington C,McInnes IB,Nibbs RJ,Goodyear CS
14-5321 was used in Flow cytometry/Cell sorting to investigate the role of ACKR2 in autoimmunity, showing that it suppresses Th17 responses to protein autoantigens.
Sun Feb 01 00:00:00 UTC 2015
Dendritic Cell-Based Vaccines that Utilize Myeloid Rather than Plasmacytoid Cells Offer a Superior Survival Advantage in Malignant Glioma.
Journal of immunology (Baltimore, Md. : 1950)
Dey M,Chang AL,Miska J,Wainwright DA,Ahmed AU,Balyasnikova IV,Pytel P,Han Y,Tobias A,Zhang L,Qiao J,Lesniak MS
14-5321 was used in Flow cytometry/Cell sorting to compare the ability of myeloid and plasmacytoid dendritic cells to generate effective antiglioma immunity.
Wed Jul 01 00:00:00 UTC 2015
Ly6C(high) monocytes control cerebral toxoplasmosis.
Journal of immunology (Baltimore, Md. : 1950)
Biswas A,Bruder D,Wolf SA,Jeron A,Mack M,Heimesaat MM,Dunay IR
14-5321 was used in Flow cytometry/Cell sorting to indicate the critical importance of recruited Ly6C monocytes upon cerebral toxoplasmosis.
Wed Apr 01 00:00:00 UTC 2015
The B subunit of Escherichia coli heat-labile toxin alters the development and antigen-presenting capacity of dendritic cells.
Journal of cellular and molecular medicine
Ji J,Griffiths KL,Milburn PJ,Hirst TR,O'Neill HC
14-5321 was used in Magnetic cell separation to investigate the direct effect of intravenously administered EtxB on the size of the dendritic and myeloid cell populations in spleen.
Sat Aug 01 00:00:00 UTC 2015
Toll-Like Receptor 4 Is an Essential Upstream Regulator of On-Time Parturition and Perinatal Viability in Mice.
Endocrinology
Wahid HH,Dorian CL,Chin PY,Hutchinson MR,Rice KC,Olson DM,Moldenhauer LM,Robertson SA
14-5321 was used in Flow cytometry/Cell sorting to describe TLR4-mediated regulation of the inflammatory response acting to drive uterine activation and control the timing of labour.
Thu Oct 01 00:00:00 UTC 2015
Loss of endogenous Nfatc1 reduces the rate of DMBA/TPA-induced skin tumorigenesis.
Molecular biology of the cell
Goldstein J,Roth E,Roberts N,Zwick R,Lin S,Fletcher S,Tadeu A,Wu C,Beck A,Zeiss C,Suárez-Fariñas M,Horsley V
14-5321 was used in Immunohistochemistry to implicate Nfatc1 in the regulation of skin stem cell-initiated tumorigenesis via the regulation of DMBA metabolism.
Thu Oct 15 00:00:00 UTC 2015
Full activation of CD4+ T cells early during sepsis requires specific antigen.
Shock (Augusta, Ga.)
Schmoeckel K,Traffehn S,Eger C,Pötschke C,Bröker BM
14-5321 was used in Flow cytometry/Cell sorting to investigate the mechanisms of T-cell activation and its consequences during sepsis, showing that full activation requires a specific antigen.
Sun Feb 01 00:00:00 UTC 2015
Reducing progression of experimental lupus nephritis via inhibition of the B7/CD28 signaling pathway.
Molecular medicine reports
Huang L,Kong Y,Wang J,Sun J,Shi Q,Qiu YH
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Tue Sep 01 00:00:00 UTC 2015
Macrophages Contribute to the Spermatogonial Niche in the Adult Testis.
Cell reports
DeFalco T,Potter SJ,Williams AV,Waller B,Kan MJ,Capel B
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Immunohistochemistry
Tue Aug 18 00:00:00 UTC 2015
Macrophages Contribute to the Spermatogonial Niche in the Adult Testis.
Cell reports
DeFalco T,Potter SJ,Williams AV,Waller B,Kan MJ,Capel B
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Immunohistochemistry
Tue Aug 18 00:00:00 UTC 2015
Ginseng Berry Extract Promotes Maturation of Mouse Dendritic Cells.
PloS one
Zhang W,Cho SY,Xiang G,Min KJ,Yu Q,Jin JO
14-5321 was used in Flow cytometry/Cell sorting to demonstrate the potential for ginseng extract as a novel therapeutic tumour vaccine adjuvant.
Wed Apr 13 00:00:00 UTC 2016
NLRC5 exclusively transactivates MHC class I and related genes through a distinctive SXY module.
PLoS genetics
Ludigs K,Seguín-Estévez Q,Lemeille S,Ferrero I,Rota G,Chelbi S,Mattmann C,MacDonald HR,Reith W,Guarda G
14-5321 was used in Flow cytometry/Cell sorting to further comprehend NLRC5's target gene specificity and mechanism of action.
Sun Mar 01 00:00:00 UTC 2015
Langerhans cell homeostasis and activation is altered in hyperplastic human papillomavirus type 16 E7 expressing epidermis.
PloS one
Abd Warif NM,Stoitzner P,Leggatt GR,Mattarollo SR,Frazer IH,Hibma MH
14-5321 was used in Flow cytometry/Cell sorting to demonstrate that the atypical activation of Langerhans cells by human papillomavirus may contribute to an immune suppressive microenvironment.
Thu Apr 14 00:00:00 UTC 2016
Fractalkine Signaling Regulates the Inflammatory Response in an α-Synuclein Model of Parkinson Disease.
PloS one
Thome AD,Standaert DG,Harms AS
14-5321 was used in Immunohistochemistry to implicate fractalkine signaling as a potential therapeutic target for regulating inflammatory response in α-syn models PD.
Tue Jun 14 00:00:00 UTC 2016
Aquaporin-9-expressing neutrophils are required for the establishment of contact hypersensitivity.
Scientific reports
Moniaga CS,Watanabe S,Honda T,Nielsen S,Hara-Chikuma M
14-5321 was used in Flow cytometry/Cell sorting to suggest that AQP9 is required for the development of sensitisation during cutaneous acquired immune responses via regulating neutrophil function.
Thu Oct 22 00:00:00 UTC 2015
Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction.
Nature communications
Rouhani SJ,Eccles JD,Riccardi P,Peske JD,Tewalt EF,Cohen JN,Liblau R,Mäkinen T,Engelhard VH
14-5321 was used in Flow cytometry/Cell sorting to demonstrate that when β-galactosidase (β-gal) is expressed in LECs, β-gal-specific CD8 T cells undergo deletion via the PD-1/PD-L1 and LAG-3/MHC-II pathways.
Fri Apr 10 00:00:00 UTC 2015
IL4I1 Is a Novel Regulator of M2 Macrophage Polarization That Can Inhibit T Cell Activation via L-Tryptophan and Arginine Depletion and IL-10 Production.
PloS one
Yue Y,Huang W,Liang J,Guo J,Ji J,Yao Y,Zheng M,Cai Z,Lu L,Wang J
14-5321 was used in Western Blotting to study the effect of IL4I1 overexpression on the expression of M2 markers (Fizz1, Arg1, YM-1, MR) and M1-associated cytokines.
Tue Jun 21 00:00:00 UTC 2016
Disease severity and mortality can be independently regulated in a mouse model of experimental graft versus host disease.
PloS one
Galvani RG,Lemos R,Areal RB,Salvador PA,Zamboni DS,Wanderley JL,Bonomo A
14-5321 was used in Flow cytometry/Cell sorting to investigate the exact cause of death in graft versus host disease, showing that disease severity and mortality can be independently regulated.
Mon Oct 19 00:00:00 UTC 2015
Conditional overexpression of TGFβ1 promotes pulmonary inflammation, apoptosis and mortality via TGFβR2 in the developing mouse lung.
Respiratory research
Sureshbabu A,Syed MA,Boddupalli CS,Dhodapkar MV,Homer RJ,Minoo P,Bhandari V
14-5321 was used in Flow cytometry/Cell sorting to investigate the mechanisms responsible for TGFβ1-induced inflammatory signals leading to abnormal alveolarization, showing that it promotes pulmonary inflammation, apoptosis and mortality via TGFβR2.
Fri Jan 16 00:00:00 UTC 2015
Latent virus infection upregulates CD40 expression facilitating enhanced autoimmunity in a model of multiple sclerosis.
Scientific reports
Casiraghi C,Márquez AC,Shanina I,Horwitz MS
14-5321 was used in Flow cytometry/Cell sorting to investigate the cause of enhanced experimental autoimmune encephalomyelitis following infection with murine γ-herpesvirus 68.
Thu Sep 10 00:00:00 UTC 2015
Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity.
Nature
Westphalen K,Gusarova GA,Islam MN,Subramanian M,Cohen TS,Prince AS,Bhattacharya J
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Immunofluorescence
Thu Feb 27 00:00:00 UTC 2014
High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity.
Nature
Schulz MD,Atay C,Heringer J,Romrig FK,Schwitalla S,Aydin B,Ziegler PK,Varga J,Reindl W,Pommerenke C,Salinas-Riester G,Böck A,Alpert C,Blaut M,Polson SC,Brandl L,Kirchner T,Greten FR,Polson SW,Arkan MC
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Thu Oct 23 00:00:00 UTC 2014
Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammation.
Immunity
Campbell EL,Bruyninckx WJ,Kelly CJ,Glover LE,McNamee EN,Bowers BE,Bayless AJ,Scully M,Saeedi BJ,Golden-Mason L,Ehrentraut SF,Curtis VF,Burgess A,Garvey JF,Sorensen A,Nemenoff R,Jedlicka P,Taylor CT,Kominsky DJ,Colgan SP
14-5321 was used in Flow cytometry/Cell sorting to investigate whether transmigrating neutrophils influence the transcriptional profile of the surrounding mucosa.
Thu Jan 16 00:00:00 UTC 2014
MHCII-mediated dialog between group 2 innate lymphoid cells and CD4(+) T cells potentiates type 2 immunity and promotes parasitic helminth expulsion.
Immunity
Oliphant CJ,Hwang YY,Walker JA,Salimi M,Wong SH,Brewer JM,Englezakis A,Barlow JL,Hams E,Scanlon ST,Ogg GS,Fallon PG,McKenzie AN
14-5321 was used in Flow cytometry/Cell sorting to demonstrate that ILC2 and T cell crosstalk contributes to their mutual maintenance, expansion and cytokine production.
Thu Aug 21 00:00:00 UTC 2014
Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells.
Nature immunology
Mahmud SA,Manlove LS,Schmitz HM,Xing Y,Wang Y,Owen DL,Schenkel JM,Boomer JS,Green JM,Yagita H,Chi H,Hogquist KA,Farrar MA
14-5321 was used in Flow cytometry/Cell sorting to study the role of TNF receptors in the thymic development of Treg cells..
Thu May 01 00:00:00 UTC 2014
Progressive replacement of embryo-derived cardiac macrophages with age.
The Journal of experimental medicine
Molawi K,Wolf Y,Kandalla PK,Favret J,Hagemeyer N,Frenzel K,Pinto AR,Klapproth K,Henri S,Malissen B,Rodewald HR,Rosenthal NA,Bajenoff M,Prinz M,Jung S,Sieweke MH
14-5321 was used in Flow cytometry/Cell sorting to report that the embryo-derived population of cardiac macrophages is progressively substituted for monocyte-derived macrophages within the first weeks after birth.
Mon Oct 20 00:00:00 UTC 2014
Immune-based antitumor effects of BRAF inhibitors rely on signaling by CD40L and IFNγ.
Cancer research
Ho PC,Meeth KM,Tsui YC,Srivastava B,Bosenberg MW,Kaech SM
14-5321 was used in Flow cytometry/Cell sorting to investigate whether B-Raf(V600E) inhibitors promote tumor regression with the help of host immunity, showing that they rely on signaling by CD40L and IFNγ.
Sun Jun 15 00:00:00 UTC 2014
Murine CD27(-) Vγ6(+) γδ T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages.
Proceedings of the National Academy of Sciences of the United States of America
Rei M,Gonçalves-Sousa N,Lança T,Thompson RG,Mensurado S,Balkwill FR,Kulbe H,Pennington DJ,Silva-Santos B
14-5321 was used in Flow cytometry/Cell sorting to characterise the role of tumour-associated γδ T cells on disease development using a model peritoneal/ovarian cancer cell line.
Tue Aug 26 00:00:00 UTC 2014
Syk signaling in dendritic cells orchestrates innate resistance to systemic fungal infection.
PLoS pathogens
Whitney PG,Bär E,Osorio F,Rogers NC,Schraml BU,Deddouche S,LeibundGut-Landmann S,Reis e Sousa C
14-5321 was used in Flow cytometry/Cell sorting to study the contribution of a specific signalling pathway involved in fungal recognition by dendritic cells during immune responses to fungal pathogens.
Tue Jul 01 00:00:00 UTC 2014
Syk signaling in dendritic cells orchestrates innate resistance to systemic fungal infection.
PLoS pathogens
Whitney PG,Bär E,Osorio F,Rogers NC,Schraml BU,Deddouche S,LeibundGut-Landmann S,Reis e Sousa C
14-5321 was used in Flow cytometry/Cell sorting to study the contribution of a specific signalling pathway involved in fungal recognition by dendritic cells during immune responses to fungal pathogens.
Tue Jul 01 00:00:00 UTC 2014
Few Foxp3⁺ regulatory T cells are sufficient to protect adult mice from lethal autoimmunity.
European journal of immunology
Mayer CT,Ghorbani P,Kühl AA,Stüve P,Hegemann M,Berod L,Gershwin ME,Sparwasser T
14-5321 was used in Flow cytometry/Cell sorting to study the mechanisms underlying why regulatory T cell-depletion fails to cause autoimmunity in adult Depletion of REGulatory T cells mice.
Wed Oct 01 00:00:00 UTC 2014
C/EBPβ expression is an independent predictor of overall survival in breast cancer patients by MHCII/CD4-dependent mechanism of metastasis formation.
Oncogenesis
Kurzejamska E,Johansson J,Jirström K,Prakash V,Ananthaseshan S,Boon L,Fuxe J,Religa P
14-5321 was used in Immunohistochemistry to determine the relationship between C/EBPβ and survival of breast cancer patients, and elucidate C/EBPβ's link with metastasis formation.
Mon Nov 03 00:00:00 UTC 2014
Distinct spatial distribution of microglia and macrophages following mesenchymal stem cell implantation in mouse brain.
Immunology and cell biology
Le Blon D,Hoornaert C,Daans J,Santermans E,Hens N,Goossens H,Berneman Z,Ponsaerts P
14-5321 was used in Immunofluorescence to characterise the distribution of microglia and macrophages in the mouse brain following mesenchymal stem cell implantation, showing that resident immune cells surround the graft site while peripheral immune cells invade the graft.
Mon Sep 01 00:00:00 UTC 2014
Characterization of conventional and atypical receptors for the chemokine CCL2 on mouse leukocytes.
Journal of immunology (Baltimore, Md. : 1950)
Ford LB,Cerovic V,Milling SW,Graham GJ,Hansell CA,Nibbs RJ
14-5321 was used in Flow cytometry/Cell sorting to define the expression profile, scavenging activity, and ligand specificity of CCL2 receptors on mouse leukocytes.
Tue Jul 01 00:00:00 UTC 2014
Adoptively transferred immune T cells eradicate established tumors despite cancer-induced immune suppression.
Journal of immunology (Baltimore, Md. : 1950)
Arina A,Schreiber K,Binder DC,Karrison TG,Liu RB,Schreiber H
14-5321 was used in Flow cytometry/Cell sorting to study the effect of adoptively transferred immune T cells in the presence of MDSCs and TAMs on established tumours, showing that they are eradicated.
Sat Feb 01 00:00:00 UTC 2014
IRF4 in dendritic cells inhibits IL-12 production and controls Th1 immune responses against Leishmania major.
Journal of immunology (Baltimore, Md. : 1950)
Akbari M,Honma K,Kimura D,Miyakoda M,Kimura K,Matsuyama T,Yui K
14-5321 was used in Flow cytometry/Cell sorting to investigate the roles of the transcription factor IRF4 in dendritic cells and macrophages in vivo.
Sat Mar 01 00:00:00 UTC 2014
A crucial role for β2 integrins in podosome formation, dynamics and Toll-like-receptor-signaled disassembly in dendritic cells.
Journal of cell science
Gawden-Bone C,West MA,Morrison VL,Edgar AJ,McMillan SJ,Dill BD,Trost M,Prescott A,Fagerholm SC,Watts C
14-5321 was used in Flow cytometry/Cell sorting to assess the contribution of integrins to the function and maintenance of podosomes.
Wed Oct 01 00:00:00 UTC 2014
Diabetes mellitus leads to accumulation of dendritic cells and nerve fiber damage of the subbasal nerve plexus in the cornea.
Investigative ophthalmology & visual science
Leppin K,Behrendt AK,Reichard M,Stachs O,Guthoff RF,Baltrusch S,Eule JC,Vollmar B
14-5321 was used in Immunohistochemistry-wholemount to investigate the potential polyneuropathic interaction between dendritic cells and the subbasal nerve plexus.
Tue Apr 29 00:00:00 UTC 2014
Treatment of congenital neurotransmitter deficiencies by intracerebral ventricular injection of an adeno-associated virus serotype 9 vector.
Human gene therapy
Lee NC,Chien YH,Hu MH,Liu WS,Chen PW,Wang WH,Tzen KY,Byrne BJ,Hwu WL
14-5321 was used in Immunohistochemistry to investigate gene therapy to treat knock-in mice with dopamine and serotonin deficiencies caused by a mutation in the aromatic L-amino acid decarboxylase (AADC) gene.
Sat Mar 01 00:00:00 UTC 2014
Nizatidine, a small molecular compound, enhances killed H5N1 vaccine cell-mediated responses and protects mice from lethal viral challenge.
Human vaccines & immunotherapeutics
Wang S,Wu B,Xue J,Wang M,Chen R,Wang B
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Mon Jan 05 00:00:00 UTC 2015
BCG vaccine mediated reduction in the MHC-II expression of macrophages and dendritic cells is reversed by activation of Toll-like receptors 7 and 9.
Cellular immunology
Bakhru P,Sirisaengtaksin N,Soudani E,Mukherjee S,Khan A,Jagannath C
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Wed Jan 01 00:00:00 UTC 2014
BCG vaccine mediated reduction in the MHC-II expression of macrophages and dendritic cells is reversed by activation of Toll-like receptors 7 and 9.
Cellular immunology
Bakhru P,Sirisaengtaksin N,Soudani E,Mukherjee S,Khan A,Jagannath C
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Wed Jan 01 00:00:00 UTC 2014
BCG vaccine mediated reduction in the MHC-II expression of macrophages and dendritic cells is reversed by activation of Toll-like receptors 7 and 9.
Cellular immunology
Bakhru P,Sirisaengtaksin N,Soudani E,Mukherjee S,Khan A,Jagannath C
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Wed Jan 01 00:00:00 UTC 2014
Pneumolysin expression by streptococcus pneumoniae protects colonized mice from influenza virus-induced disease.
Virology
Wolf AI,Strauman MC,Mozdzanowska K,Williams KL,Osborne LC,Shen H,Liu Q,Garlick D,Artis D,Hensley SE,Caton AJ,Weiser JN,Erikson J
14-5321-82 was used in Flow Cytometry to investigate severity of influenza virus response with respiratory microbe presence.
Fri Aug 01 00:00:00 UTC 2014
Amniotic fluid stem cells prevent follicle atresia and rescue fertility of mice with premature ovarian failure induced by chemotherapy.
PloS one
Xiao GY,Liu IH,Cheng CC,Chang CC,Lee YH,Cheng WT,Wu SC
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Thu May 28 00:00:00 UTC 2015
Assessing the role of STAT3 in DC differentiation and autologous DC immunotherapy in mouse models of GBM.
PloS one
Assi H,Espinosa J,Suprise S,Sofroniew M,Doherty R,Zamler D,Lowenstein PR,Castro MG
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Fri Jan 23 00:00:00 UTC 2015
Assessing the role of STAT3 in DC differentiation and autologous DC immunotherapy in mouse models of GBM.
PloS one
Assi H,Espinosa J,Suprise S,Sofroniew M,Doherty R,Zamler D,Lowenstein PR,Castro MG
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Fri Jan 23 00:00:00 UTC 2015
A systems biology approach to the analysis of subset-specific responses to lipopolysaccharide in dendritic cells.
PloS one
Hancock DG,Shklovskaya E,Guy TV,Falsafi R,Fjell CD,Ritchie W,Hancock RE,Fazekas de St Groth B
14-5321 was used in Flow cytometry/Cell sorting to propose a model in which signalling through common pathways are 'fine-tuned' by transcriptional control of subset-specific modulators, causing distinct outcomes.
Tue Oct 13 00:00:00 UTC 2015
Three distinct subsets of thymic epithelial cells in rats and mice defined by novel antibodies.
PloS one
Sawanobori Y,Ueta H,Dijkstra CD,Park CG,Satou M,Kitazawa Y,Matsuno K
14-5321 was used in Immunohistochemistry to create a precise map of rat thymic epithelial cells using antibodies to putative markers and novel monoclonal antibodies.
Fri Jun 26 00:00:00 UTC 2015
Identification of Toll-like receptor 9 as parapoxvirus ovis-sensing receptor in plasmacytoid dendritic cells.
PloS one
von Buttlar H,Siegemund S,Büttner M,Alber G
14-5321 was used in an ELISA assay to identify endosomal TLR9 as PPVO-sensing receptor in pDC.
Tue Nov 10 00:00:00 UTC 2015
Effector CD4 T-cell transition to memory requires late cognate interactions that induce autocrine IL-2.
Nature communications
McKinstry KK,Strutt TM,Bautista B,Zhang W,Kuang Y,Cooper AM,Swain SL
14532182 was used in flow cytometry to explore the interaction between IL-2 and IL-7 in CD4 T-cell memory generation
Wed Nov 05 00:00:00 UTC 2014
The MacBlue binary transgene (csf1r-gal4VP16/UAS-ECFP) provides a novel marker for visualisation of subsets of monocytes, macrophages and dendritic cells and responsiveness to CSF1 administration.
PloS one
Sauter KA,Pridans C,Sehgal A,Bain CC,Scott C,Moffat L,Rojo R,Stutchfield BM,Davies CL,Donaldson DS,Renault K,McColl BW,Mowat AM,Serrels A,Frame MC,Mabbott NA,Hume DA
14-5321 was used in Flow cytometry/Cell sorting to examine expression of the MacBlue transgene in embryos and adult mice.
Fri Dec 18 00:00:00 UTC 2015
RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3.
Nature
Lukens JR,Vogel P,Johnson GR,Kelliher MA,Iwakura Y,Lamkanfi M,Kanneganti TD
14-5321 was used in Flow cytometry/Cell sorting to investigate how mutations in SHP-1 causes inflammatory disease, showing that RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3.
Thu Jun 13 00:00:00 UTC 2013
IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8⁺ T cell responses to influenza A virus.
Nature immunology
Pang IK,Ichinohe T,Iwasaki A
14-5321 was used in Flow cytometry/Cell sorting to demonstrate the critical role of the bystander cytokine IL-1 in priming CD8+ T cell responses to influenza A virus during infection.
Fri Mar 01 00:00:00 UTC 2013
Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis.
Nature immunology
Taketomi Y,Ueno N,Kojima T,Sato H,Murase R,Yamamoto K,Tanaka S,Sakanaka M,Nakamura M,Nishito Y,Kawana M,Kambe N,Ikeda K,Taguchi R,Nakamizo S,Kabashima K,Gelb MH,Arita M,Yokomizo T,Nakamura M,Watanabe K,Hirai H,Nakamura M,Okayama Y,Ra C,Aritake K,Urade Y,Morimoto K,Sugimoto Y,Shimizu T,Narumiya S,Hara S,Murakami M
14-5321 was used in Flow cytometry/Cell sorting to report that PLA2G3, a mammalian homolog of anaphylactic bee venom phospholipase A2, regulates mast cell maturation via a lipid mediator circuit.
Sat Jun 01 00:00:00 UTC 2013
Efficient influenza A virus replication in the respiratory tract requires signals from TLR7 and RIG-I.
Proceedings of the National Academy of Sciences of the United States of America
Pang IK,Pillai PS,Iwasaki A
14-5321 was used in Flow cytometry/Cell sorting to suggest that IAV uses physiological levels of inflammatory responses for its replicative advantage and highlight the complex interplay between viruses and the host innate-immune responses.
Tue Aug 20 00:00:00 UTC 2013
Plxnd1 expression in thymocytes regulates their intrathymic migration while that in thymic endothelium impacts medullary topology.
Frontiers in immunology
Choi YI,Duke-Cohan JS,Tan J,Gui J,Singh MK,Epstein JA,Reinherz EL
14-5321 was used in Immunohistochemistry to show the non-redundant roles for plexinD1 on thymocytes and endothelium, including medulla formation resulting from crosstalk between thymic cellular components.
Fri Dec 06 00:00:00 UTC 2013
Klf10 inhibits IL-12p40 production in macrophage colony-stimulating factor-induced mouse bone marrow-derived macrophages.
European journal of immunology
Zhang W,Wang X,Xia X,Liu X,Suo S,Guo J,Li M,Cao W,Cai Z,Hui Z,Subramaniam M,Spelsberg TC,Wang J,Wang L
14-5321 was used in Flow cytometry/Cell sorting to identify Klf10 as a transcription factor that regulates the expression of IL-12p40 in bone marrow-derived macrophages.
Tue Jan 01 00:00:00 UTC 2013
Temporal requirements for B cells in the establishment of CD4 T cell memory.
Journal of immunology (Baltimore, Md. : 1950)
Mollo SB,Zajac AJ,Harrington LE
14-5321 was used in Flow cytometry/Cell sorting to demonstrate the temporally and functionally distinct roles for B cells in regulating CD4 T cell responses.
Sun Dec 15 00:00:00 UTC 2013
Syndecan-1, a cell surface proteoglycan, negatively regulates initial leukocyte recruitment to the brain across the choroid plexus in murine experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Zhang X,Wu C,Song J,Götte M,Sorokin L
14-5321 was used in Flow cytometry/Cell sorting to investigate how the choroid plexus epithelium is a novel source of IL-6 in EAE and demonstrate that its expression negatively correlates with syndecan-1 expression at this site.
Fri Nov 01 00:00:00 UTC 2013
Targeting of autoantigens to DEC205⁺ dendritic cells in vivo suppresses experimental allergic encephalomyelitis in mice.
Journal of immunology (Baltimore, Md. : 1950)
Ring S,Maas M,Nettelbeck DM,Enk AH,Mahnke K
14-5321 was used in Immunohistochemistry to investigate whether targeting EAE-related peptides to steady-state dendritic cells induces Tregs and rescues mice from EAE symptoms.
Sun Sep 15 00:00:00 UTC 2013
FOXM1 promotes allergen-induced goblet cell metaplasia and pulmonary inflammation.
Molecular and cellular biology
Ren X,Shah TA,Ustiyan V,Zhang Y,Shinn J,Chen G,Whitsett JA,Kalin TV,Kalinichenko VV
14-5321 was used in Flow cytometry/Cell sorting to investigate the role of transcriptional control of goblet cell differentiation and mucus hyperproduction, showing that FOXM1 promotes allergen-induced metaplasia and pulmonary inflammation.
Tue Jan 01 00:00:00 UTC 2013
Mature dendritic cell suppression by IL-1 receptor antagonist on retinal pigment epithelium cells.
Investigative ophthalmology & visual science
Sugita S,Kawazoe Y,Imai A,Usui Y,Iwakura Y,Isoda K,Ito M,Mochizuki M
14-5321 was used in Immunohistochemistry to demonstrate that ocular resident cells can produce pro-inflammatory cytokine antagonists that suppress antigen-presenting cell activation.
Tue May 07 00:00:00 UTC 2013
CD38 controls the innate immune response against Listeria monocytogenes.
Infection and immunity
Lischke T,Heesch K,Schumacher V,Schneider M,Haag F,Koch-Nolte F,Mittrücker HW
14-5321 was used in Flow cytometry/Cell sorting to evaluate the key enzymes governing the innate immune response.
Fri Nov 01 00:00:00 UTC 2013
Phosphatidylserine exposure on the surface of Leishmania amazonensis amastigotes modulates in vivo infection and dendritic cell function.
Parasite immunology
Wanderley JLM,Thorpe PE,Barcinski MA,Soong L
14-5321 was used in Flow cytometry/Cell sorting to provide new information regarding the mechanism of immune suppression in Leishmania infection.
Wed Jul 17 00:00:00 UTC 2013
The timing of TGF-β inhibition affects the generation of antigen-specific CD8+ T cells.
BMC immunology
Quatromoni JG,Suzuki E,Okusanya O,Judy BF,Bhojnagarwala P,Venegas O,Eruslanov E,Predina JD,Albelda SM,Singhal S
14-5321 was used in Flow cytometry/Cell sorting to investigate how TGF-β may be necessary for anti-tumor immune responses in certain cancers.
Wed Jul 17 00:00:00 UTC 2013
Autophagy adaptor protein p62/SQSTM1 and autophagy-related gene Atg5 mediate autophagosome formation in response to Mycobacterium tuberculosis infection in dendritic cells.
PloS one
Seto S,Tsujimura K,Horii T,Koide Y
14-5321-82 was used in Immunocytochemistry to characterise autophagosome formation in response to Mycobacterium tuberculosis infection in dendritic cells.
Mon Jul 28 00:00:00 UTC 2014
Foxp3+ regulatory T cells are required for recovery from severe sepsis.
PloS one
Kühlhorn F,Rath M,Schmoeckel K,Cziupka K,Nguyen HH,Hildebrandt P,Hünig T,Sparwasser T,Huehn J,Pötschke C,Bröker BM
14-5321 was used in Flow cytometry/Cell sorting to determine the sufficiency of the suppressive capacity of Tregs for controlling inflammation due to sepsis.
Fri Jan 10 00:00:00 UTC 2014
NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells.
Nature
Eisenbarth SC,Williams A,Colegio OR,Meng H,Strowig T,Rongvaux A,Henao-Mejia J,Thaiss CA,Joly S,Gonzalez DG,Xu L,Zenewicz LA,Haberman AM,Elinav E,Kleinstein SH,Sutterwala FS,Flavell RA
14-5321 was used in Flow cytometry/Cell sorting to elucidate the in vivo biological role of NLRP10 by investigating immunity in Nlrp10-/- mice.
Wed Apr 25 00:00:00 UTC 2012
Endothelial cells provide an instructive niche for the differentiation and functional polarization of M2-like macrophages.
Blood
He H,Xu J,Warren CM,Duan D,Li X,Wu L,Iruela-Arispe ML
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Thu Oct 11 00:00:00 UTC 2012
DNGR-1 is a specific and universal marker of mouse and human Batf3-dependent dendritic cells in lymphoid and nonlymphoid tissues.
Blood
Poulin LF,Reyal Y,Uronen-Hansson H,Schraml BU,Sancho D,Murphy KM,Håkansson UK,Moita LF,Agace WW,Bonnet D,Reis e Sousa C
14-5321 was used in Flow cytometry/Cell sorting to investigate the presence of unique markers in human dendritic cells, showing that DNGR-1 is a specific marker of mouse and human dendritic cells in lymphoid and nonlymphoid tissues.
Thu Jun 21 00:00:00 UTC 2012
Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells.
Blood
Tewalt EF,Cohen JN,Rouhani SJ,Guidi CJ,Qiao H,Fahl SP,Conaway MR,Bender TP,Tung KS,Vella AT,Adler AJ,Chen L,Engelhard VH
14-5321 was used in Flow cytometry/Cell sorting to demonstrate that LECs mediate deletion only via programmed cell death-1 (PD-1) ligand 1.
Thu Dec 06 00:00:00 UTC 2012
Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice.
The Journal of experimental medicine
Billiard F,Lobry C,Darrasse-Jèze G,Waite J,Liu X,Mouquet H,DaNave A,Tait M,Idoyaga J,Leboeuf M,Kyratsous CA,Burton J,Kalter J,Klinakis A,Zhang W,Thurston G,Merad M,Steinman RM,Murphy AJ,Yancopoulos GD,Aifantis I,Skokos D
14-5321 was used in Flow cytometry/Cell sorting to investigate how Dll4-Notch signaling affects pro-T cell fate and thymic DC development, showing that it is a novel Flt3-independent pathway for DC development and autoimmunity.
Mon May 07 00:00:00 UTC 2012
Unexpected role for MHC II-peptide complexes in shaping CD8 T-cell expansion and differentiation in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Do JS,Valujskikh A,Vignali DA,Fairchild RL,Min B
14-5321 was used in Flow cytometry/Cell sorting to reveal a previously undefined MHC II-dependent regulation that tunes CD8 T-cell reactivity.
Tue Jul 31 00:00:00 UTC 2012
Epithelial expression of the cytosolic retinoid chaperone cellular retinol binding protein II is essential for in vivo imprinting of local gut dendritic cells by lumenal retinoids.
The American journal of pathology
McDonald KG,Leach MR,Brooke KWM,Wang C,Wheeler LW,Hanly EK,Rowley CW,Levin MS,Wagner M,Li E,Newberry RD
14-5321 was used in Flow cytometry/Cell sorting to study dendritic cell production of all-trans retinoic acid (ATRA) in vivo.
Thu Mar 01 00:00:00 UTC 2012
Exposure to nicotine adversely affects the dendritic cell system and compromises host response to vaccination.
Journal of immunology (Baltimore, Md. : 1950)
Nouri-Shirazi M,Guinet E
14-5321 was used in Flow cytometry/Cell sorting to investigate the causal relationship between nicotine-induced dendritic cell alterations and host response to vaccines.
Thu Mar 01 00:00:00 UTC 2012
An anti-nucleic acid antibody delivers antigen to the cross-presentation pathway in dendritic cells and potentiates therapeutic antitumor effects.
Journal of immunology (Baltimore, Md. : 1950)
Pham CD,Woo MY,Kim YS,Park S,Kwon MH
14-5321 was used in Flow cytometry/Cell sorting to report a new antigenic carrier molecule which facilitates the inhibition of in vivo tumour growth.
Sat Dec 15 00:00:00 UTC 2012
NK cells are required for costimulatory blockade induced tolerance to vascularized allografts.
Transplantation
van der Touw W,Burrell B,Lal G,Bromberg JS
14-5321 was used in Immunohistochemistry on frozen tissues to investigate the role of NK cells in allograft tolerance, showing that they are required for costimulatory blockade induced tolerance to vascularised allografts.
Thu Sep 27 00:00:00 UTC 2012
Preferential colonization of metastases by oncolytic vaccinia virus strain GLV-1h68 in a human PC-3 prostate cancer model in nude mice.
PloS one
Donat U,Weibel S,Hess M,Stritzker J,Härtl B,Sturm JB,Chen NG,Gentschev I,Szalay AA
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Immunofluorescence
Tue May 07 00:00:00 UTC 2013
Isolation and characterization of novel murine epiphysis derived mesenchymal stem cells.
PloS one
Cheng CC,Lian WS,Hsiao FS,Liu IH,Lin SP,Lee YH,Chang CC,Xiao GY,Huang HY,Cheng CF,Cheng WT,Wu SC
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Fri Sep 07 00:00:00 UTC 2012
Murine corneal stroma cells inhibit LPS-induced dendritic cell maturation partially through TGF-β2 secretion in vitro.
Molecular vision
Lu JM,Song XJ,Wang HF,Li XL,Zhang XR
14-5321 was used in Flow cytometry/Cell sorting to investigate the factors that inhibit the maturation of DCs in the central cornea.
Fri Dec 21 00:00:00 UTC 2012
Dectin-1-triggered recruitment of light chain 3 protein to phagosomes facilitates major histocompatibility complex class II presentation of fungal-derived antigens.
The Journal of biological chemistry
Ma J,Becker C,Lowell CA,Underhill DM
14-5321 was used in Immunofluorescence to elucidate the role of Dectin-1 and LC3II in the innate immune response against fungi in mice.
Fri Oct 05 00:00:00 UTC 2012
Suppression of dendritic cell maturation and T cell proliferation by synovial fluid myeloid cells from mice with autoimmune arthritis.
Arthritis and rheumatism
Egelston C,Kurkó J,Besenyei T,Tryniszewska B,Rauch TA,Glant TT,Mikecz K
14-5321 was used in Blocking experiments to investigate the effects of synovial fluid cells from mice with proteoglycan-induced arthritis on dendritic cell maturation and antigen-specific T-cell proliferation.
Mon Oct 01 00:00:00 UTC 2012
DC mobilization from the skin requires docking to immobilized CCL21 on lymphatic endothelium and intralymphatic crawling.
The Journal of experimental medicine
Tal O,Lim HY,Gurevich I,Milo I,Shipony Z,Ng LG,Angeli V,Shakhar G
14-5321 was used in Immunohistochemistry-wholemount to demonstrate the role of the CCL21-CCR7 axis in DC mobilization: promoting chemotaxis and arrest of DCs on lymphatic endothelium.
Mon Sep 26 00:00:00 UTC 2011
Development of a sarcoidosis murine lung granuloma model using Mycobacterium superoxide dismutase A peptide.
American journal of respiratory cell and molecular biology
Swaisgood CM,Oswald-Richter K,Moeller SD,Klemenc JM,Ruple LM,Farver CF,Drake JM,Culver DA,Drake WP
14-5321 was used in Flow cytometry/Cell sorting to provide the framework to investigate the molecular basis for the progression or resolution of sarcoidosis.
Tue Feb 01 00:00:00 UTC 2011
A LysM and SH3-domain containing region of the Listeria monocytogenes p60 protein stimulates accessory cells to promote activation of host NK cells.
PLoS pathogens
Schmidt RL,Filak HC,Lemon JD,Potter TA,Lenz LL
14-5321 was used in Flow cytometry/Cell sorting to demonstrate an immune stimulating function for a bacterial LysM domain-containing polypeptide.
Tue Nov 01 00:00:00 UTC 2011
Retinoic acid as a vaccine adjuvant enhances CD8+ T cell response and mucosal protection from viral challenge.
Journal of virology
Tan X,Sande JL,Pufnock JS,Blattman JN,Greenberg PD
14-5321 was used in Flow cytometry/Cell sorting to test whether the administration of retinoic acid could establish better protection from viral infection via mucosal routes.
Mon Aug 01 00:00:00 UTC 2011
Regressed lymphatic vessels develop during corneal repair.
Laboratory investigation; a journal of technical methods and pathology
Kelley PM,Steele MM,Tempero RM
14-5321 was used in Immunofluorescence to determine the morphologic, phenotypic, and functional differences in regressing lymphatic vessels in the cornea following inflammation.
Tue Nov 01 00:00:00 UTC 2011
Identification of semaphorin 4B as a negative regulator of basophil-mediated immune responses.
Journal of immunology (Baltimore, Md. : 1950)
Nakagawa Y,Takamatsu H,Okuno T,Kang S,Nojima S,Kimura T,Kataoka TR,Ikawa M,Toyofuku T,Katayama I,Kumanogoh A
14-5321 was used in Immunohistochemistry on paraffin embedded tissues to screen semaphorins for immune involvement, identifying Sema4B as a suppressor of basophil-mediated Th2-skewing.
Tue Mar 01 00:00:00 UTC 2011
CSF-1-dependent red pulp macrophages regulate CD4 T cell responses.
Journal of immunology (Baltimore, Md. : 1950)
Kurotaki D,Kon S,Bae K,Ito K,Matsui Y,Nakayama Y,Kanayama M,Kimura C,Narita Y,Nishimura T,Iwabuchi K,Mack M,van Rooijen N,Sakaguchi S,Uede T,Morimoto J
14-5321 was used in Flow cytometry/Cell sorting to show tissue macrophages residing in the red pulp showed different expression patterns of surface markers compared with F4/80(+)Mac-1(hi) monocytes.
Tue Feb 15 00:00:00 UTC 2011
Mouse neutrophils are professional antigen-presenting cells programmed to instruct Th1 and Th17 T-cell differentiation.
International immunology
Abi Abdallah DS,Egan CE,Butcher BA,Denkers EY
14-5321 was used in Blocking experiments to demonstrate that neutrophils can prime antigen-specific T(h)1 and T(h)17 immune responses even without addition of exogenous cytokines to cell cultures.
Sun May 01 00:00:00 UTC 2011
TCA cycle inactivation in Staphylococcus aureus alters nitric oxide production in RAW 264.7 cells.
Molecular and cellular biochemistry
Massilamany C,Gangaplara A,Gardner DJ,Musser JM,Steffen D,Somerville GA,Reddy J
14-5321 was used in Flow cytometry/Cell sorting to study the mechanisms by which Staphylococci can evade innate immune responses and enhance their ability to survive in infected hosts.
Thu Sep 01 00:00:00 UTC 2011
Efficient induction of CD25- iTreg by co-immunization requires strongly antigenic epitopes for T cells.
BMC immunology
Geng S,Yu Y,Kang Y,Pavlakis G,Jin H,Li J,Hu Y,Hu W,Wang S,Wang B
14-5321 was used in Blocking experiments to investigate the antigenic requirements for the induction of CD25- inducible regulatory T cells.
Thu May 05 00:00:00 UTC 2011
FTY720 reduces post-ischemic brain lymphocyte influx but does not improve outcome in permanent murine cerebral ischemia.
PloS one
Liesz A,Sun L,Zhou W,Schwarting S,Mracsko E,Zorn M,Bauer H,Sommer C,Veltkamp R
14-5321 was used in Flow cytometry/Cell sorting to detect a reduction of lymphocyte brain invasion by FTY720.
Fri Oct 14 00:00:00 UTC 2011
IL25 elicits a multipotent progenitor cell population that promotes T(H)2 cytokine responses.
Nature
Saenz SA,Siracusa MC,Perrigoue JG,Spencer SP,Urban JF,Tocker JE,Budelsky AL,Kleinschek MA,Kastelein RA,Kambayashi T,Bhandoola A,Artis D
14-5321 was used in Functional assays to study the connection between the IL-17 cytokine family and medullary haematopoiesis.
Thu Apr 29 00:00:00 UTC 2010
Regulation of medullary thymic epithelial cell differentiation and function by the signaling protein Sin.
The Journal of experimental medicine
Danzl NM,Donlin LT,Alexandropoulos K
14-5321 was used in Flow cytometry/Cell sorting to reveal the role of the signalling protein Sin in the thymic stroma, specifically in medullary thymic epithelial cells.
Mon May 10 00:00:00 UTC 2010
Gap junctions between regulatory T cells and dendritic cells prevent sensitization of CD8(+) T cells.
The Journal of allergy and clinical immunology
Ring S,Karakhanova S,Johnson T,Enk AH,Mahnke K
14-5321 was used in Immunohistochemistry to determine that Treg cells suppress CD8+ T cell sensitisation by interfering with the T-cell stimulatory activity of dendritic cells via intercellular gap junctions.
Fri Jan 01 00:00:00 UTC 2010
CD137 ligand signaling induces human monocyte to dendritic cell differentiation.
European journal of immunology
Kwajah M M S,Schwarz H
14-5321 was used in Flow cytometry/Cell sorting to deduce that peripheral monocytes can be differentiated into mature inflammatory dendritic cells by the single factor CD137.
Thu Jul 01 00:00:00 UTC 2010
Recipient Toll-like receptors contribute to chronic graft dysfunction by both MyD88- and TRIF-dependent signaling.
Disease models & mechanisms
Wang S,Schmaderer C,Kiss E,Schmidt C,Bonrouhi M,Porubsky S,Gretz N,Schaefer L,Kirschning CJ,Popovic ZV,Gröne HJ
14-5321 was used in Flow cytometry/Cell sorting to test whether toll-like receptors influence chronic fibrosing inflammation.
Wed Mar 10 00:00:00 UTC 2010
The innate immune response to uropathogenic Escherichia coli involves IL-17A in a murine model of urinary tract infection.
Journal of immunology (Baltimore, Md. : 1950)
Sivick KE,Schaller MA,Smith SN,Mobley HL
14-5321 was used in Flow cytometry/Cell sorting to show that IL-17A is a key mediator for the innate immune response to UTIs.
Mon Feb 15 00:00:00 UTC 2010
Cryptococcus neoformans variants generated by phenotypic switching differ in virulence through effects on macrophage activation.
Infection and immunity
Guerrero A,Jain N,Wang X,Fries BC
14-5321 was used in Flow cytometry/Cell sorting to investigate the interaction between macrophages and cells from smooth-colony or mucoid-colony variants arising from phenotypic switching of Cryptococcus neoformans.
Mon Mar 01 00:00:00 UTC 2010
Identification of gp96 as a novel target for treatment of autoimmune disease in mice.
PloS one
Han JM,Kwon NH,Lee JY,Jeong SJ,Jung HJ,Kim HR,Li Z,Kim S
14-5321 was used in Flow cytometry/Cell sorting to suggest that surface translocation of gp96 can be chemically controlled and gp96 as a potential therapeutic autoimmune disease treatment.
Tue Mar 23 00:00:00 UTC 2010
Pattern recognition scavenger receptor SRA/CD204 down-regulates Toll-like receptor 4 signaling-dependent CD8 T-cell activation.
Blood
Yi H,Yu X,Gao P,Wang Y,Baek SH,Chen X,Kim HL,Subjeck JR,Wang XY
14-5321 was used in Immunofluorescence to reveal a previously unrecognised role for SRA/CD204 as a physiologic negative regulator of TLR4-mediated immune consequences.
Thu Jun 04 00:00:00 UTC 2009
Differential roles of migratory and resident DCs in T cell priming after mucosal or skin HSV-1 infection.
The Journal of experimental medicine
Lee HK,Zamora M,Linehan MM,Iijima N,Gonzalez D,Haberman A,Iwasaki A
14-5321 was used in Flow cytometry/Cell sorting to to study the differential roles of migratory and resident DC's in T cell priming after mucosal or skin HSV-1 infection.
Mon Feb 16 00:00:00 UTC 2009
Migratory and antigen presentation functions of IFN-producing killer dendritic cells.
Cancer research
Himoudi N,Yan M,Bouma G,Morgenstern D,Wallace R,Seddon B,Buddle J,Eddaoudi A,Howe SJ,Cooper N,Anderson J
14-5321 was used in Flow cytometry/Cell sorting to study how BM-IKDCs are capable of cytotoxic killing of tumour targets, and also of potent antigen presentation after encountering antigen in the context of a viable target cell.
Sat Aug 15 00:00:00 UTC 2009
Annexin-1-deficient dendritic cells acquire a mature phenotype during differentiation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Huggins A,Paschalidis N,Flower RJ,Perretti M,D'Acquisto F
14-5321 was used in Flow cytometry/Cell sorting to suggest that the inhibition of Anx-A1 expression in dendritic cells may be useful to modulate the adaptive immune response in pathogen-induced immune diseases.
Wed Apr 01 00:00:00 UTC 2009
SIGNR1-negative red pulp macrophages protect against acute streptococcal sepsis after Leishmania donovani-induced loss of marginal zone macrophages.
The American journal of pathology
Kirby AC,Beattie L,Maroof A,van Rooijen N,Kaye PM
14-5321 was used in Flow cytometry/Cell sorting to show the protective activity of SIGNR1(+) marginal zone macrophages can be compensated for by activated red pulp macrophages.
Tue Sep 01 00:00:00 UTC 2009
Sialoadhesin-positive macrophages bind regulatory T cells, negatively controlling their expansion and autoimmune disease progression.
Journal of immunology (Baltimore, Md. : 1950)
Wu C,Rauch U,Korpos E,Song J,Loser K,Crocker PR,Sorokin LM
14-5321 was used in Flow cytometry/Cell sorting to propose a new direct cell-cell interaction-based mechanism regulating the expansion of Tregs during autoimmune and inflammatory processes.
Fri May 15 00:00:00 UTC 2009
Glycolipids injected into the skin are presented to NKT cells in the draining lymph node independently of migratory skin dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Tripp CH,Sparber F,Hermans IF,Romani N,Stoitzner P
14-5321 was used in Flow cytometry/Cell sorting to demonstrate that intradermally applied glycolipids are presented predominantly by lymph node, not skin, DCs to NKT cells.
Mon Jun 15 00:00:00 UTC 2009
Mycobacterium bovis BCG decreases MHC-II expression in vivo on murine lung macrophages and dendritic cells during aerosol infection.
Cellular immunology
Pecora ND,Fulton SA,Reba SM,Drage MG,Simmons DP,Urankar-Nagy NJ,Boom WH,Harding CV
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Flow Cytometry
Fri Jan 02 00:00:00 UTC 2009
Peripheral dendritic cells are essential for both the innate and adaptive antiviral immune responses in the central nervous system.
Virology
Steel CD,Hahto SM,Ciavarra RP
14-5321-82 was used in Flow Cytometry to study the adaptive primary antiviral immune response in the CNS and the effect of dendritic cells upon this in vivo.
Sat Apr 25 00:00:00 UTC 2009
The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues.
Nature immunology
Waskow C,Liu K,Darrasse-Jèze G,Guermonprez P,Ginhoux F,Merad M,Shengelia T,Yao K,Nussenzweig M
14-5321-82 was used in Immunohistochemistry to investigate the hematopoietic growth factors regulating dendritic development.
Sun Jun 01 00:00:00 UTC 2008
The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues.
Nature immunology
Waskow C,Liu K,Darrasse-Jèze G,Guermonprez P,Ginhoux F,Merad M,Shengelia T,Yao K,Nussenzweig M
14-5321-82 was used in Immunohistochemistry to investigate the hematopoietic growth factors regulating dendritic development.
Sun Jun 01 00:00:00 UTC 2008
Dendritic cells and B cells maximize mucosal Th1 memory response to herpes simplex virus.
The Journal of experimental medicine
Iijima N,Linehan MM,Zamora M,Butkus D,Dunn R,Kehry MR,Laufer TM,Iwasaki A
14-5321 was used in Immunofluorescence to investigate the antiviral mechanism of Th1, showing that dendritic cells and B cells maximise mucosal Th1 memory response to herpes simplex virus.
Mon Dec 22 00:00:00 UTC 2008
Differential role of gamma interferon in inhibiting pulmonary eosinophilia and exacerbating systemic disease in fusion protein-immunized mice undergoing challenge infection with respiratory syncytial virus.
Journal of virology
Castilow EM,Olson MR,Meyerholz DK,Varga SM
14-5321 was used in Flow cytometry/Cell sorting to compare the immune response elicited by the G versus F protein of the respiratory syncytial virus, showing a differential role of gamma interferon.
Sat Mar 01 00:00:00 UTC 2008
17beta-Estradiol's salutary effects on splenic dendritic cell functions following trauma-hemorrhage are mediated via estrogen receptor-alpha.
Molecular immunology
Kawasaki T,Choudhry MA,Suzuki T,Schwacha MG,Bland KI,Chaudry IH
14-5321 was used in Flow cytometry/Cell sorting to investigate the effect of 17beta-estradiol on splenic dendritic cell function, showing that beneficial effects occur via estrogen receptor-alpha.
Tue Jan 01 00:00:00 UTC 2008
Age-dependent tolerance to an endogenous tumor-associated antigen.
Vaccine
McWilliams JA,Sullivan RT,Jordan KR,McMahan RH,Kemmler CB,McDuffie M,Slansky JE
14-5321 was used in Flow cytometry/Cell sorting to determine the role of gp70 expression in the T cell response to a transplantable CT26 colon carcinoma tumour in mice.
Fri Mar 28 00:00:00 UTC 2008
Functionally specialized junctions between endothelial cells of lymphatic vessels.
The Journal of experimental medicine
Baluk P,Fuxe J,Hashizume H,Romano T,Lashnits E,Butz S,Vestweber D,Corada M,Molendini C,Dejana E,McDonald DM
14-5321 was used in Immunohistochemistry to suggest that fluid enters throughout initial lymphatics via openings between buttons, which open and close without disrupting junctional integrity.
Mon Oct 01 00:00:00 UTC 2007
Normal development and function of invariant natural killer T cells in mice with isoglobotrihexosylceramide (iGb3) deficiency.
Proceedings of the National Academy of Sciences of the United States of America
Porubsky S,Speak AO,Luckow B,Cerundolo V,Platt FM,Gröne HJ
14-5321 was used in Flow cytometry/Cell sorting to investigate the role of iGb3 in iNKT cell selection.
Tue Apr 03 00:00:00 UTC 2007
Characterization and modeling of monocyte-derived macrophages after spinal cord injury.
Journal of neurochemistry
Longbrake EE,Lai W,Ankeny DP,Popovich PG
14-5321 was used in Flow cytometry/Cell sorting to characterise and model monocyte-derived macrophages after spinal cord injury.
Wed Aug 01 00:00:00 UTC 2007
TRIF-GEFH1-RhoB pathway is involved in MHCII expression on dendritic cells that is critical for CD4 T-cell activation.
The EMBO journal
Kamon H,Kawabe T,Kitamura H,Lee J,Kamimura D,Kaisho T,Akira S,Iwamatsu A,Koga H,Murakami M,Hirano T
14-5321 was used in Immunohistochemistry-immunofluorescence to study the involvement of a TRIF-GEFH1-RhoB pathway in MHCII surface expression on dendritic cells.
Wed Sep 06 00:00:00 UTC 2006
Infiltration of inflammatory cells plays an important role in matrix metalloproteinase expression and activation in the heart during sepsis.
The American journal of pathology
Cuenca J,Martín-Sanz P,Alvarez-Barrientos AM,Boscá L,Goren N
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 14-5321-82) in Immunohistochemistry
Wed Nov 01 00:00:00 UTC 2006
An effective cancer vaccine modality: lentiviral modification of dendritic cells expressing multiple cancer-specific antigens.
Vaccine
Wang B,He J,Liu C,Chang LJ
14-5321 was used in Inhibition experiments to examine the therapeutic potential of dendritic cells modified with lentiviral vectors expressing multiple tumour-associated antigens.
Mon Apr 24 00:00:00 UTC 2006
Disruption of Id1 reveals major differences in angiogenesis between transplanted and autochthonous tumors.
Cancer cell
Sikder H,Huso DL,Zhang H,Wang B,Ryu B,Hwang ST,Powell JD,Alani RM
14-5321-82 was used in Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Neutralization, Western Blot to investigate differences between transplanted and autochthonous tumors in Id1 levels.
Wed Oct 01 00:00:00 UTC 2003
[Public health in Spain].
Revista de sanidad e higiene publica
Martínez Navarro JF
Fri Sep 01 00:00:00 UTC 1978
