Proteintech

SDHA Polyclonal Antibody

SDHA Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 17

SDHA Antibody (14865-1-AP) in ICC/IF

Immunofluorescent analysis of ( 4% PFA) fixed HepG2 cells using 14865-1-AP (SDHA antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

SDHA Antibody in Immunohistochemistry (Paraffin) (IHC (P))

SDHA Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

SDHA Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

14865-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 74 publications 74 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:400

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:50-1:500

View 3 publications 3 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 2 publications 2 publications

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Pig, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SDHA Fusion Protein Ag6677 (336-664 aa encoded by BC001380)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: DLASRDVVS RSMTLEIREG RGCGPEKDHV YLQLHHLPPE QLATRLPGIS ETAMIFAGVD VTKEPIPVLP TVHYNMGGIP TNYKGQVLRH VNGQDQIVPG LYACGEAACA SVHGANRLGA NSLLDLVVFG RACALSIEES CRPGDKVPPI KPNAGEESVM NLDKLRFADG SIRTSELRLS MQKSMQNHAA VFRVGSVLQE GCGKISKLYG DLKHLKTFDR GMVWNTDLVE TLELQNLMLC ALQTIYGAEA RKESRGAHAR EDYKVRIDEY DYSKPIQGQQ KKPFEEHWRK HTLSYVDVGT GKVTLEYRPV IDKTLNEADC ATVPPAIRSY (336-664 aa encoded by BC001380)

Target Information

This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Dietary cobalt oxide nanoparticles alleviate aging through activation of mitochondrial UPR in Caenorhabditis elegans.

Theranostics

Cong W,Wang Y,Yuan C,Xu M,Wang H,Hu Y,Dai X,Weng Y,Timashev P,Liang XJ,Huang Y

Mon Jun 26 00:00:00 EDT 2023

Delivery of low-density lipoprotein from endocytic carriers to mitochondria supports steroidogenesis.

Nature cell biology

Zhou YX,Wei J,Deng G,Hu A,Sun PY,Zhao X,Song BL,Luo J

Sat Jul 01 00:00:00 EDT 2023

Delivery of low-density lipoprotein from endocytic carriers to mitochondria supports steroidogenesis.

Nature cell biology

Zhou YX,Wei J,Deng G,Hu A,Sun PY,Zhao X,Song BL,Luo J

Sat Jul 01 00:00:00 EDT 2023

Comprehensive analysis of the prognosis, tumor microenvironment, and immunotherapy response of SDHs in colon adenocarcinoma.

Frontiers in immunology

Nan H,Guo P,Fan J,Zeng W,Hu C,Zheng C,Pan B,Cao Y,Ge Y,Xue X,Li W,Lin K

Fri Mar 24 00:00:00 EDT 2023

Rab8a as a mitochondrial receptor for lipid droplets in skeletal muscle.

Developmental cell

Ouyang Q,Chen Q,Ke S,Ding L,Yang X,Rong P,Feng W,Cao Y,Wang Q,Li M,Su S,Wei W,Liu M,Liu J,Zhang X,Li JZ,Wang HY,Chen S

Mon Feb 27 00:00:00 EST 2023

Mitochondrial Methionyl-tRNA Formyltransferase Deficiency Alleviates Metaflammation by Modulating Mitochondrial Activity in Mice.

International journal of molecular sciences

Sun X,Liu S,Cai J,Yang M,Li C,Tan M,He B

Wed Mar 22 00:00:00 EDT 2023

Multi-Cell Line Analysis of Lysosomal Proteomes Reveals Unique Features and Novel Lysosomal Proteins.

Molecular & cellular proteomics : MCP

Akter F,Bonini S,Ponnaiyan S,Kögler-Mohrbacher B,Bleibaum F,Damme M,Renard BY,Winter D

Wed Mar 01 00:00:00 EST 2023

Synergistic effects of lipopolysaccharide and rotenone on dopamine neuronal damage in rats.

CNS neuroscience & therapeutics

He JY,Li DD,Wen Q,Qin TY,Long H,Zhang SB,Zhang F

Tue Aug 01 00:00:00 EDT 2023

Saturated fatty acids increase LPI to reduce FUNDC1 dimerization and stability and mitochondrial function.

EMBO reports

Chen L,Zhang Q,Meng Y,Zhao T,Mu C,Fu C,Deng C,Feng J,Du S,Liu W,Geng G,Ma K,Cheng H,Liu Q,Luo Q,Zhang J,Du Z,Cao L,Wang H,Liu Y,Lin J,Chen G,Liu L,Lam SM,Shui G,Zhu Y,Chen Q

Wed Apr 05 00:00:00 EDT 2023

NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral immunity.

The EMBO journal

Zhao T,Zhang J,Lei H,Meng Y,Cheng H,Zhao Y,Geng G,Mu C,Chen L,Liu Q,Luo Q,Zhang C,Long Y,Su J,Wang Y,Li Z,Sun J,Chen G,Li Y,Liao X,Shang Y,Hu G,Chen Q,Zhu Y

Tue Aug 15 00:00:00 EDT 2023

5-HEPE reduces obesity and insulin resistance by promoting adipose tissue browning through GPR119/AMPK/PGC1α activation.

Life sciences

Zong Y,Wang M,Liu Y,Suo X,Fan G,Yang X

Thu Jun 15 00:00:00 EDT 2023

Impaired mitophagy causes mitochondrial DNA leakage and STING activation in ultraviolet B-irradiated human keratinocytes HaCaT.

Archives of biochemistry and biophysics

Li C,Zhu Y,Liu W,Xiang W,He S,Hayashi T,Mizuno K,Hattori S,Fujisaki H,Ikejima T

Wed Mar 15 00:00:00 EDT 2023

Cardiolipin and OPA1 Team up for Methamphetamine-Induced Locomotor Activity by Promoting Neuronal Mitochondrial Fusion in the Nucleus Accumbens of Mice.

ACS chemical neuroscience

Wang L,Wei Q,Xu R,Chen Y,Li S,Bu Q,Zhao Y,Li H,Zhao Y,Jiang L,Chen Y,Dai Y,Zhao Y,Cen X

Wed May 03 00:00:00 EDT 2023

Role of molybdenum in material immunomodulation and periodontal wound healing: Targeting immunometabolism and mitochondrial function for macrophage modulation.

Biomaterials

He XT,Li X,Zhang M,Tian BM,Sun LJ,Bi CS,Deng DK,Zhou H,Qu HL,Wu C,Chen FM

Fri Apr 01 00:00:00 EDT 2022

FNIP1 regulates adipocyte browning and systemic glucose homeostasis in mice by shaping intracellular calcium dynamics.

The Journal of experimental medicine

Yin Y,Xu D,Mao Y,Xiao L,Sun Z,Liu J,Zhou D,Xu Z,Liu L,Fu T,Ding C,Guo Q,Sun W,Zhou Z,Yang L,Jia Y,Chen X,Gan Z

Mon May 02 00:00:00 EDT 2022

Loss of Sam50 in hepatocytes induces cardiolipin-dependent mitochondrial membrane remodeling to trigger mtDNA release and liver injury.

Hepatology (Baltimore, Md.)

Chen L,Dong J,Liao S,Wang S,Wu Z,Zuo M,Liu B,Yan C,Chen Y,He H,Meng Q,Song Z

Tue Nov 01 00:00:00 EDT 2022

Non-canonical phosphoglycerate dehydrogenase activity promotes liver cancer growth via mitochondrial translation and respiratory metabolism.

The EMBO journal

Shu Y,Hao Y,Feng J,Liu H,Li ST,Feng J,Jiang Z,Ye L,Zhou Y,Sun Y,Zhou Z,Wei H,Gao P,Zhang H,Sun L

Thu Dec 01 00:00:00 EST 2022

A redox cycle with complex II prioritizes sulfide quinone oxidoreductase-dependent H₂S oxidation.

The Journal of biological chemistry

Kumar R,Landry AP,Guha A,Vitvitsky V,Lee HJ,Seike K,Reddy P,Lyssiotis CA,Banerjee R

Sat Jan 01 00:00:00 EST 2022

LONP1-mediated mitochondrial quality control safeguards metabolic shifts in heart development.

Development (Cambridge, England)

Zhao K,Huang X,Zhao W,Lu B,Yang Z

Tue Mar 15 00:00:00 EDT 2022

Inhibition of High-Temperature Requirement Protein A2 Protease Activity Represses Myogenic Differentiation via UPRmt.

International journal of molecular sciences

Sun H,Shen L,Zhang P,Lin F,Ma J,Wu Y,Yu H,Sun L

Tue Oct 04 00:00:00 EDT 2022

Maternal Herpesviridae infection during pregnancy alters midbrain dopaminergic signatures in adult offspring.

Neurobiology of disease

Burmeister AR,Gordevicius J,Paul EN,Houck C,George S,Escobar Galvis ML,Sha Q,Brundin P,Pospisilik JA,Racicot K,Brundin L

Fri Jul 01 00:00:00 EDT 2022

Hydrogen Peroxide Promotes the Production of Radiation-Derived EVs Containing Mitochondrial Proteins.

Antioxidants (Basel, Switzerland)

Miller CE,Xu F,Zhao Y,Luo W,Zhong W,Meyer K,Jayswal R,Weiss HL,St Clair WH,St Clair DK,Chaiswing L

Thu Oct 27 00:00:00 EDT 2022

Dopamine receptor D1 signaling stimulates lipolysis and browning of white adipocytes.

Biochemical and biophysical research communications

Yu J,Zhu J,Deng J,Shen J,Du F,Wu X,Chen Y,Li M,Wen Q,Xiao Z,Zhao Y

Sat Jan 15 00:00:00 EST 2022

Global mitochondrial protein import proteomics reveal distinct regulation by translation and translocation machinery.

Molecular cell

Schäfer JA,Bozkurt S,Michaelis JB,Klann K,Münch C

Thu Jan 20 00:00:00 EST 2022

Mitochondrial protein hyperacetylation underpins heart failure with preserved ejection fraction in mice.

Journal of molecular and cellular cardiology

Liu X,Zhang Y,Deng Y,Yang L,Ou W,Xie M,Ding L,Jiang C,Yu H,Li Q,Li T

Fri Apr 01 00:00:00 EDT 2022

Mitochondrial protein hyperacetylation underpins heart failure with preserved ejection fraction in mice.

Journal of molecular and cellular cardiology

Liu X,Zhang Y,Deng Y,Yang L,Ou W,Xie M,Ding L,Jiang C,Yu H,Li Q,Li T

Fri Apr 01 00:00:00 EDT 2022

Activation of Dynamin-Related Protein 1 and Induction of Mitochondrial Apoptosis by Exosome-Rifampicin Nanoparticles Exerts Anti-Osteosarcoma Effect.

International journal of nanomedicine

Chen W,Lin W,Yu N,Zhang L,Wu Z,Chen Y,Li Z,Gong F,Li N,Chen X,He X,Wu Y,Zeng X,Yueh Y,Xu R,Ji G

Mon Nov 28 00:00:00 EST 2022

Bromodomain-containing protein 4 (BRD4) as an epigenetic regulator of fatty acid metabolism genes and ferroptosis.

Cell death & disease

Yang M,Liu K,Chen P,Zhu H,Wang J,Huang J

Sat Oct 29 00:00:00 EDT 2022

Mitochondrial proteostasis stress in muscle drives a long-range protective response to alleviate dietary obesity independently of ATF4.

Science advances

Guo Q,Xu Z,Zhou D,Fu T,Wang W,Sun W,Xiao L,Liu L,Ding C,Yin Y,Zhou Z,Sun Z,Zhu Y,Zhou W,Jia Y,Xue J,Chen Y,Chen XW,Piao HL,Lu B,Gan Z

Fri Jul 29 00:00:00 EDT 2022

Cross-linking of the endolysosomal system reveals potential flotillin structures and cargo.

Nature communications

Singh J,Elhabashy H,Muthukottiappan P,Stepath M,Eisenacher M,Kohlbacher O,Gieselmann V,Winter D

Thu Oct 20 00:00:00 EDT 2022

CHCHD2 and CHCHD10 regulate mitochondrial dynamics and integrated stress response.

Cell death & disease

Ruan Y,Hu J,Che Y,Liu Y,Luo Z,Cheng J,Han Q,He H,Zhou Q

Wed Feb 16 00:00:00 EST 2022

Specialist multidisciplinary input maximises rare disease diagnoses from whole genome sequencing.

Nature communications

Macken WL,Falabella M,McKittrick C,Pizzamiglio C,Ellmers R,Eggleton K,Woodward CE,Patel Y,Labrum R,Phadke R,Reilly MM,DeVile C,Sarkozy A,Footitt E,Davison J,Rahman S,Houlden H,Bugiardini E,Quinlivan R,Hanna MG,Vandrovcova J,Pitceathly RDS

Mon Nov 07 00:00:00 EST 2022

Disuse-associated loss of the protease LONP1 in muscle impairs mitochondrial function and causes reduced skeletal muscle mass and strength.

Nature communications

Xu Z,Fu T,Guo Q,Zhou D,Sun W,Zhou Z,Chen X,Zhang J,Liu L,Xiao L,Yin Y,Jia Y,Pang E,Chen Y,Pan X,Fang L,Zhu MS,Fei W,Lu B,Gan Z

Wed Feb 16 00:00:00 EST 2022

Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination.

The Journal of cell biology

Oshima Y,Cartier E,Boyman L,Verhoeven N,Polster BM,Huang W,Kane M,Lederer WJ,Karbowski M

Mon Jun 07 00:00:00 EDT 2021

ALS/FTD mutations in UBQLN2 are linked to mitochondrial dysfunction through loss-of-function in mitochondrial protein import.

Human molecular genetics

Lin BC,Phung TH,Higgins NR,Greenslade JE,Prado MA,Finley D,Karbowski M,Polster BM,Monteiro MJ

Thu Jun 17 00:00:00 EDT 2021

Leber's Hereditary Optic Neuropathy Arising From the Synergy Between ND1 3635G>A Mutation and Mitochondrial YARS2 Mutations.

Investigative ophthalmology & visual science

Jin X,Zhang J,Yi Q,Meng F,Yu J,Ji Y,Mo JQ,Tong Y,Jiang P,Guan MX

Tue Jun 01 00:00:00 EDT 2021

Deficiency of β-carotene oxygenase 2 induces mitochondrial fragmentation and activates the STING-IRF3 pathway in the mouse hypothalamus.

The Journal of nutritional biochemistry

Wu L,Guo X,Wong SY,Lu P,Hartson SD,Medeiros DM,Wang W,Clarke SL,Lucas EA,Smith BJ,Chowanadisai W,Lin D

Mon Feb 01 00:00:00 EST 2021

Fumarate is a terminal electron acceptor in the mammalian electron transport chain.

Science (New York, N.Y.)

Spinelli JB,Rosen PC,Sprenger HG,Puszynska AM,Mann JL,Roessler JM,Cangelosi AL,Henne A,Condon KJ,Zhang T,Kunchok T,Lewis CA,Chandel NS,Sabatini DM

Fri Dec 03 00:00:00 EST 2021

Proteomic analysis demonstrates the role of the quality control protease LONP1 in mitochondrial protein aggregation.

The Journal of biological chemistry

Pollecker K,Sylvester M,Voos W

Fri Oct 01 00:00:00 EDT 2021

Proteomic analysis demonstrates the role of the quality control protease LONP1 in mitochondrial protein aggregation.

The Journal of biological chemistry

Pollecker K,Sylvester M,Voos W

Fri Oct 01 00:00:00 EDT 2021

Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response.

Nature communications

Wang W,Li J,Tan J,Wang M,Yang J,Zhang ZM,Li C,Basnakian AG,Tang HW,Perrimon N,Zhou Q

Wed Jan 20 00:00:00 EST 2021

The Protective Effect of 1,25(OH)₂D₃ on Myocardial Function is Mediated via Sirtuin 3-Regulated Fatty Acid Metabolism.

Frontiers in cell and developmental biology

Yang J,Zhang Y,Pan Y,Sun C,Liu Z,Liu N,Fu Y,Li X,Li Y,Kong J

Fri May 14 00:00:00 EDT 2021

Low chorionic villous succinate accumulation associates with recurrent spontaneous abortion risk.

Nature communications

Wang XH,Xu S,Zhou XY,Zhao R,Lin Y,Cao J,Zang WD,Tao H,Xu W,Li MQ,Zhao SM,Jin LP,Zhao JY

Tue Jun 08 00:00:00 EDT 2021

Empagliflozin Induces White Adipocyte Browning and Modulates Mitochondrial Dynamics in KK Cg-Ay/J Mice and Mouse Adipocytes.

Frontiers in physiology

Xu L,Xu C,Liu X,Li X,Li T,Yu X,Xue M,Yang J,Kosmas CE,Moris D,Sanchis-Gomar F,Yoshida N,Berger NA,Aronow WS,Sun B,Chen L

Wed Nov 17 00:00:00 EST 2021

Spermine Protects Cardiomyocytes from High Glucose-Induced Energy Disturbance by Targeting the CaSR-gp78-Ubiquitin Proteasome System.

Cardiovascular drugs and therapy

Wang Y,Wang Y,Li F,Zhang X,Li H,Yang G,Xu C,Wei C

Mon Feb 01 00:00:00 EST 2021

Increased Expression of DNA2 Was Linked to Poor Prognosis in Breast Cancer.

Disease markers

Han Y,Zhang Z,Wang Z,Sun S

Fri Oct 29 00:00:00 EDT 2021

Celecoxib reverses the glioblastoma chemo-resistance to temozolomide through mitochondrial metabolism.

Aging

Yin D,Jin G,He H,Zhou W,Fan Z,Gong C,Zhao J,Xiong H

Wed Sep 08 00:00:00 EDT 2021

An animal model for mitochondrial tyrosyl-tRNA synthetase deficiency reveals links between oxidative phosphorylation and retinal function.

The Journal of biological chemistry

Jin X,Zhang Z,Nie Z,Wang C,Meng F,Yi Q,Chen M,Sun J,Zou J,Jiang P,Guan MX

Mon Aug 02 00:00:00 EDT 2021

APOL1 risk variants affect podocyte lipid homeostasis and energy production in focal segmental glomerulosclerosis.

Human molecular genetics

Ge M,Molina J,Ducasa GM,Mallela SK,Varona Santos J,Mitrofanova A,Kim JJ,Liu X,Sloan A,Mendez AJ,Banerjee S,Liu S,Szeto HH,Shin MK,Hoek M,Kopp JB,Fontanesi F,Merscher S,Fornoni A

Mon Apr 26 00:00:00 EDT 2021

OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development.

EMBO reports

Wu Z,Zuo M,Zeng L,Cui K,Liu B,Yan C,Chen L,Dong J,Shangguan F,Hu W,He H,Lu B,Song Z

Thu Jan 07 00:00:00 EST 2021

Tissue-specific expression atlas of murine mitochondrial tRNAs.

The Journal of biological chemistry

He Q,He X,Xiao Y,Zhao Q,Ye Z,Cui L,Chen Y,Guan MX

Sun Aug 01 00:00:00 EDT 2021

The requirement for pyruvate dehydrogenase in leukemogenesis depends on cell lineage.

Cell metabolism

Jun S,Mahesula S,Mathews TP,Martin-Sandoval MS,Zhao Z,Piskounova E,Agathocleous M

Tue Sep 07 00:00:00 EDT 2021

Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Sensing by Dendritic Cells in Psoriasis.

Immunity

Lou F,Sun Y,Xu Z,Niu L,Wang Z,Deng S,Liu Z,Zhou H,Bai J,Yin Q,Cai X,Sun L,Wang H,Li Q,Wu Z,Chen X,Gu J,Shi YL,Tao W,Ginhoux F,Wang H

Tue Jul 14 00:00:00 EDT 2020

Histochemical and immunohistochemical staining methods to visualize mitochondrial proteins and activity.

Methods in cell biology

Franco-Iborra S,Tanji K

Thu Dec 24 00:00:00 EST 2020

Sam50-Mic19-Mic60 axis determines mitochondrial cristae architecture by mediating mitochondrial outer and inner membrane contact.

Cell death and differentiation

Tang J,Zhang K,Dong J,Yan C,Hu C,Ji H,Chen L,Chen S,Zhao H,Song Z

Wed Jan 01 00:00:00 EST 2020

Fluoride-induced renal dysfunction via respiratory chain complex abnormal expression and fusion elevation in mice.

Chemosphere

Wang HW,Zhu SQ,Liu J,Miao CY,Zhang Y,Zhou BH

Wed Jan 01 00:00:00 EST 2020

Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis.

Nature metabolism

Li ST,Huang D,Shen S,Cai Y,Xing S,Wu G,Jiang Z,Hao Y,Yuan M,Wang N,Zhu L,Yan R,Yang D,Wang L,Liu Z,Hu X,Zhou R,Qu K,Li A,Duan X,Zhang H,Gao P

Sun Mar 01 00:00:00 EST 2020

Drp1-mediated mitochondrial fission contributes to baicalein-induced apoptosis and autophagy in lung cancer via activation of AMPK signaling pathway.

International journal of biological sciences

Deng X,Liu J,Liu L,Sun X,Huang J,Dong J

Mon Sep 27 00:00:00 EDT 2021

Mitochondrial respiratory chain damage and mitochondrial fusion disorder are involved in liver dysfunction of fluoride-induced mice.

Chemosphere

Wang HW,Liu J,Wei SS,Zhao WP,Zhu SQ,Zhou BH

Sat Feb 01 00:00:00 EST 2020

p53/PGC‑1α‑mediated mitochondrial dysfunction promotes PC3 prostate cancer cell apoptosis.

Molecular medicine reports

Li J,Li Y,Chen L,Yu B,Xue Y,Guo R,Su J,Liu Y,Sun L

Wed Jul 01 00:00:00 EDT 2020

The combination of metformin and 2-deoxyglucose significantly inhibits cyst formation in miniature pigs with polycystic kidney disease.

British journal of pharmacology

Lian X,Wu X,Li Z,Zhang Y,Song K,Cai G,Li Q,Lin S,Chen X,Bai XY

Fri Mar 01 00:00:00 EST 2019

The combination of metformin and 2-deoxyglucose significantly inhibits cyst formation in miniature pigs with polycystic kidney disease.

British journal of pharmacology

Lian X,Wu X,Li Z,Zhang Y,Song K,Cai G,Li Q,Lin S,Chen X,Bai XY

Fri Mar 01 00:00:00 EST 2019

Benzoylaconine induces mitochondrial biogenesis in mice via activating AMPK signaling cascade.

Acta pharmacologica Sinica

Deng XH,Liu JJ,Sun XJ,Dong JC,Huang JH

Wed May 01 00:00:00 EDT 2019

Benzoylaconine induces mitochondrial biogenesis in mice via activating AMPK signaling cascade.

Acta pharmacologica Sinica

Deng XH,Liu JJ,Sun XJ,Dong JC,Huang JH

Wed May 01 00:00:00 EDT 2019

Deletion of Gtpbp3 in zebrafish revealed the hypertrophic cardiomyopathy manifested by aberrant mitochondrial tRNA metabolism.

Nucleic acids research

Chen D,Zhang Z,Chen C,Yao S,Yang Q,Li F,He X,Ai C,Wang M,Guan MX

Tue Jun 04 00:00:00 EDT 2019

Ginkgolic Acids Impair Mitochondrial Function by Decreasing Mitochondrial Biogenesis and Promoting FUNDC1-Dependent Mitophagy.

Journal of agricultural and food chemistry

Wang W,Wang M,Ruan Y,Tan J,Wang H,Yang T,Li J,Zhou Q

Wed Sep 11 00:00:00 EDT 2019

Artemisinin suppresses hepatocellular carcinoma cell growth, migration and invasion by targeting cellular bioenergetics and Hippo-YAP signaling.

Archives of toxicology

Li Y,Lu J,Chen Q,Han S,Shao H,Chen P,Jin Q,Yang M,Shangguan F,Fei M,Wang L,Liu Y,Liu N,Lu B

Fri Nov 01 00:00:00 EDT 2019

SIRT5-mediated SDHA desuccinylation promotes clear cell renal cell carcinoma tumorigenesis.

Free radical biology & medicine

Ma Y,Qi Y,Wang L,Zheng Z,Zhang Y,Zheng J

Mon Apr 01 00:00:00 EDT 2019

SIRT5-mediated SDHA desuccinylation promotes clear cell renal cell carcinoma tumorigenesis.

Free radical biology & medicine

Ma Y,Qi Y,Wang L,Zheng Z,Zhang Y,Zheng J

Mon Apr 01 00:00:00 EDT 2019

Promotion of Mitochondrial Biogenesis via Activation of AMPK-PGC1α Signaling Pathway by Ginger (Zingiber officinale Roscoe) Extract, and Its Major Active Component 6-Gingerol.

Journal of food science

Deng X,Zhang S,Wu J,Sun X,Shen Z,Dong J,Huang J

Thu Aug 01 00:00:00 EDT 2019

Increase of core temperature affected the progression of kidney injury by repeated heat stress exposure.

American journal of physiology. Renal physiology

Sato Y,Roncal-Jimenez CA,Andres-Hernando A,Jensen T,Tolan DR,Sanchez-Lozada LG,Newman LS,Butler-Dawson J,Sorensen C,Glaser J,Miyazaki M,Diaz HF,Ishimoto T,Kosugi T,Maruyama S,Garcia GE,Lanaspa MA,Johnson RJ

Fri Nov 01 00:00:00 EDT 2019

Mitochondrial respiratory chain dysfunction mediated by ROS is a primary point of fluoride-induced damage in Hepa1-6 cells.

Environmental pollution (Barking, Essex : 1987)

Wang HW,Zhang Y,Tan PP,Jia LS,Chen Y,Zhou BH

Sun Dec 01 00:00:00 EST 2019

AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity.

Cell metabolism

Luo H,Jiang M,Lian G,Liu Q,Shi M,Li TY,Song L,Ye J,He Y,Yao L,Zhang C,Lin ZZ,Zhang CS,Zhao TJ,Jia WP,Li P,Lin SY,Lin SC

Tue Apr 03 00:00:00 EDT 2018

AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity.

Cell metabolism

Luo H,Jiang M,Lian G,Liu Q,Shi M,Li TY,Song L,Ye J,He Y,Yao L,Zhang C,Lin ZZ,Zhang CS,Zhao TJ,Jia WP,Li P,Lin SY,Lin SC

Tue Apr 03 00:00:00 EDT 2018

Mitophagy Directs Muscle-Adipose Crosstalk to Alleviate Dietary Obesity.

Cell reports

Fu T,Xu Z,Liu L,Guo Q,Wu H,Liang X,Zhou D,Xiao L,Liu L,Liu Y,Zhu MS,Chen Q,Gan Z

Tue May 01 00:00:00 EDT 2018

Mitophagy Directs Muscle-Adipose Crosstalk to Alleviate Dietary Obesity.

Cell reports

Fu T,Xu Z,Liu L,Guo Q,Wu H,Liang X,Zhou D,Xiao L,Liu L,Liu Y,Zhu MS,Chen Q,Gan Z

Tue May 01 00:00:00 EDT 2018

CUE domain-containing protein 2 promotes the Warburg effect and tumorigenesis.

EMBO reports

Zhong X,Tian S,Zhang X,Diao X,Dong F,Yang J,Li Z,Sun L,Wang L,He X,Wu G,Hu X,Wang L,Song L,Zhang H,Pan X,Li A,Gao P

Mon May 01 00:00:00 EDT 2017

CUE domain-containing protein 2 promotes the Warburg effect and tumorigenesis.

EMBO reports

Zhong X,Tian S,Zhang X,Diao X,Dong F,Yang J,Li Z,Sun L,Wang L,He X,Wu G,Hu X,Wang L,Song L,Zhang H,Pan X,Li A,Gao P

Mon May 01 00:00:00 EDT 2017

Lack of β, β-carotene-9', 10'-oxygenase 2 leads to hepatic mitochondrial dysfunction and cellular oxidative stress in mice.

Molecular nutrition & food research

Wu L,Guo X,Hartson SD,Davis MA,He H,Medeiros DM,Wang W,Clarke SL,Lucas EA,Smith BJ,von Lintig J,Lin D

Mon May 01 00:00:00 EDT 2017

Lack of β, β-carotene-9', 10'-oxygenase 2 leads to hepatic mitochondrial dysfunction and cellular oxidative stress in mice.

Molecular nutrition & food research

Wu L,Guo X,Hartson SD,Davis MA,He H,Medeiros DM,Wang W,Clarke SL,Lucas EA,Smith BJ,von Lintig J,Lin D

Mon May 01 00:00:00 EDT 2017

DJ-1 modulates mitochondrial response to oxidative stress: clues from a novel diagnosis of PARK7.

Clinical genetics

Di Nottia M,Masciullo M,Verrigni D,Petrillo S,Modoni A,Rizzo V,Di Giuda D,Rizza T,Niceta M,Torraco A,Bianchi M,Santoro M,Bentivoglio AR,Bertini E,Piemonte F,Carrozzo R,Silvestri G

Sat Jul 01 00:00:00 EDT 2017

DJ-1 modulates mitochondrial response to oxidative stress: clues from a novel diagnosis of PARK7.

Clinical genetics

Di Nottia M,Masciullo M,Verrigni D,Petrillo S,Modoni A,Rizzo V,Di Giuda D,Rizza T,Niceta M,Torraco A,Bianchi M,Santoro M,Bentivoglio AR,Bertini E,Piemonte F,Carrozzo R,Silvestri G

Sat Jul 01 00:00:00 EDT 2017

The changes in glucose metabolism and cell proliferation in the kidneys of polycystic kidney disease mini-pig models.

Biochemical and biophysical research communications

Lian X,Zhao J,Wu X,Zhang Y,Li Q,Lin S,Bai XY,Chen X

Sat Jun 24 00:00:00 EDT 2017

The changes in glucose metabolism and cell proliferation in the kidneys of polycystic kidney disease mini-pig models.

Biochemical and biophysical research communications

Lian X,Zhao J,Wu X,Zhang Y,Li Q,Lin S,Bai XY,Chen X

Sat Jun 24 00:00:00 EDT 2017

Calcium sensing receptor protects high glucose-induced energy metabolism disorder via blocking gp78-ubiquitin proteasome pathway.

Cell death & disease

Wang Y,Gao P,Wei C,Li H,Zhang L,Zhao Y,Wu B,Tian Y,Zhang W,Wu L,Wang R,Xu C

Thu May 18 00:00:00 EDT 2017

Calcium sensing receptor protects high glucose-induced energy metabolism disorder via blocking gp78-ubiquitin proteasome pathway.

Cell death & disease

Wang Y,Gao P,Wei C,Li H,Zhang L,Zhao Y,Wu B,Tian Y,Zhang W,Wu L,Wang R,Xu C

Thu May 18 00:00:00 EDT 2017

Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization.

Cell death and differentiation

Li H,Ruan Y,Zhang K,Jian F,Hu C,Miao L,Gong L,Sun L,Zhang X,Chen S,Chen H,Liu D,Song Z

Tue Mar 01 00:00:00 EST 2016

Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization.

Cell death and differentiation

Li H,Ruan Y,Zhang K,Jian F,Hu C,Miao L,Gong L,Sun L,Zhang X,Chen S,Chen H,Liu D,Song Z

Tue Mar 01 00:00:00 EST 2016

Oral quercetin administration transiently protects respiratory function in dystrophin-deficient mice.

The Journal of physiology

Selsby JT,Ballmann CG,Spaulding HR,Ross JW,Quindry JC

Sat Oct 15 00:00:00 EDT 2016

Oral quercetin administration transiently protects respiratory function in dystrophin-deficient mice.

The Journal of physiology

Selsby JT,Ballmann CG,Spaulding HR,Ross JW,Quindry JC

Sat Oct 15 00:00:00 EDT 2016

COA7 (C1orf163/RESA1) mutations associated with mitochondrial leukoencephalopathy and cytochrome c oxidase deficiency.

Journal of medical genetics

Martinez Lyons A,Ardissone A,Reyes A,Robinson AJ,Moroni I,Ghezzi D,Fernandez-Vizarra E,Zeviani M

Thu Dec 01 00:00:00 EST 2016

COA7 (C1orf163/RESA1) mutations associated with mitochondrial leukoencephalopathy and cytochrome c oxidase deficiency.

Journal of medical genetics

Martinez Lyons A,Ardissone A,Reyes A,Robinson AJ,Moroni I,Ghezzi D,Fernandez-Vizarra E,Zeviani M

Thu Dec 01 00:00:00 EST 2016

CYC1 Predicts Poor Prognosis in Patients with Breast Cancer.

Disease markers

Han Y,Sun S,Zhao M,Zhang Z,Gong S,Gao P,Liu J,Zhou J,Ma D,Gao Q,Wu P

Mon Feb 20 00:00:00 EST 2017

CYC1 Predicts Poor Prognosis in Patients with Breast Cancer.

Disease markers

Han Y,Sun S,Zhao M,Zhang Z,Gong S,Gao P,Liu J,Zhou J,Ma D,Gao Q,Wu P

Mon Feb 20 00:00:00 EST 2017

Exercise Inducible Lactate Dehydrogenase B Regulates Mitochondrial Function in Skeletal Muscle.

The Journal of biological chemistry

Liang X,Liu L,Fu T,Zhou Q,Zhou D,Xiao L,Liu J,Kong Y,Xie H,Yi F,Lai L,Vega RB,Kelly DP,Smith SR,Gan Z

Fri Dec 02 00:00:00 EST 2016

Exercise Inducible Lactate Dehydrogenase B Regulates Mitochondrial Function in Skeletal Muscle.

The Journal of biological chemistry

Liang X,Liu L,Fu T,Zhou Q,Zhou D,Xiao L,Liu J,Kong Y,Xie H,Yi F,Lai L,Vega RB,Kelly DP,Smith SR,Gan Z

Fri Dec 02 00:00:00 EST 2016

EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer.

The EMBO journal

Zhang J,Wang C,Chen X,Takada M,Fan C,Zheng X,Wen H,Liu Y,Wang C,Pestell RG,Aird KM,Kaelin WG,Liu XS,Zhang Q

Wed Dec 02 00:00:00 EST 2015

EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer.

The EMBO journal

Zhang J,Wang C,Chen X,Takada M,Fan C,Zheng X,Wen H,Liu Y,Wang C,Pestell RG,Aird KM,Kaelin WG,Liu XS,Zhang Q

Wed Dec 02 00:00:00 EST 2015

Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1.

Nature communications

Ma X,Li C,Sun L,Huang D,Li T,He X,Wu G,Yang Z,Zhong X,Song L,Gao P,Zhang H

Fri Oct 10 00:00:00 EDT 2014

Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1.

Nature communications

Ma X,Li C,Sun L,Huang D,Li T,He X,Wu G,Yang Z,Zhong X,Song L,Gao P,Zhang H

Fri Oct 10 00:00:00 EDT 2014

Bioinformatics

Protein Aliases: Flavoprotein subunit of complex II; Fp; Malate dehydrogenase [quinone] flavoprotein subunit; succinate dehydrogenase [ubiquinone] flavoprotein subunit; Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; succinate dehydrogenase complex subunit A, flavoprotein (Fp); succinate dehydrogenase complex, subunit A, flavoprotein (Fp)

View more View less

Gene Aliases: 1500032O14Rik; 2310034D06Rik; 4921513A11; C81073; CMD1GG; FP; PGL5; SDH1; SDH2; SDHA; SDHF

View more View less

UniProt ID: (Human) Q59GW8, (Rat) Q920L2, (Mouse) Q8K2B3

View more View less

Entrez Gene ID: (Human) 6389, (Rat) 157074, (Mouse) 66945

View more View less

Function(s)

succinate dehydrogenase activity protein binding succinate dehydrogenase (ubiquinone) activity flavin adenine dinucleotide binding oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors dehydrogenase oxidoreductase metabolite interconversion enzyme

Process(es)

tricarboxylic acid cycle succinate metabolic process nervous system development respiratory electron transport chain oxidation-reduction process transport electron transport chain

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

SDHA Polyclonal Antibody

SDHA Antibody (14865-1-AP) in ICC/IF

Product Details

14865-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!