Proteintech

SDHA Polyclonal Antibody

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Antibody Testing Data (17)

SDHA Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 17

SDHA Antibody (14865-1-AP) in ICC/IF

Immunofluorescent analysis of ( 4% PFA) fixed HepG2 cells using 14865-1-AP (SDHA antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

SDHA Antibody in Immunohistochemistry (Paraffin) (IHC (P))

SDHA Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

SDHA Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

14865-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 74 publications 74 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:400

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:50-1:500

View 3 publications 3 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 2 publications 2 publications

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Pig, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SDHA Fusion Protein Ag6677 (336-664 aa encoded by BC001380)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: DLASRDVVS RSMTLEIREG RGCGPEKDHV YLQLHHLPPE QLATRLPGIS ETAMIFAGVD VTKEPIPVLP TVHYNMGGIP TNYKGQVLRH VNGQDQIVPG LYACGEAACA SVHGANRLGA NSLLDLVVFG RACALSIEES CRPGDKVPPI KPNAGEESVM NLDKLRFADG SIRTSELRLS MQKSMQNHAA VFRVGSVLQE GCGKISKLYG DLKHLKTFDR GMVWNTDLVE TLELQNLMLC ALQTIYGAEA RKESRGAHAR EDYKVRIDEY DYSKPIQGQQ KKPFEEHWRK HTLSYVDVGT GKVTLEYRPV IDKTLNEADC ATVPPAIRSY (336-664 aa encoded by BC001380)

Target Information

This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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DJ-1 modulates mitochondrial response to oxidative stress: clues from a novel diagnosis of PARK7.

Clinical genetics

Di Nottia M,Masciullo M,Verrigni D,Petrillo S,Modoni A,Rizzo V,Di Giuda D,Rizza T,Niceta M,Torraco A,Bianchi M,Santoro M,Bentivoglio AR,Bertini E,Piemonte F,Carrozzo R,Silvestri G

Sat Jul 01 00:00:00 EDT 2017

The changes in glucose metabolism and cell proliferation in the kidneys of polycystic kidney disease mini-pig models.

Biochemical and biophysical research communications

Lian X,Zhao J,Wu X,Zhang Y,Li Q,Lin S,Bai XY,Chen X

Sat Jun 24 00:00:00 EDT 2017

The changes in glucose metabolism and cell proliferation in the kidneys of polycystic kidney disease mini-pig models.

Biochemical and biophysical research communications

Lian X,Zhao J,Wu X,Zhang Y,Li Q,Lin S,Bai XY,Chen X

Sat Jun 24 00:00:00 EDT 2017

Calcium sensing receptor protects high glucose-induced energy metabolism disorder via blocking gp78-ubiquitin proteasome pathway.

Cell death & disease

Wang Y,Gao P,Wei C,Li H,Zhang L,Zhao Y,Wu B,Tian Y,Zhang W,Wu L,Wang R,Xu C

Thu May 18 00:00:00 EDT 2017

Calcium sensing receptor protects high glucose-induced energy metabolism disorder via blocking gp78-ubiquitin proteasome pathway.

Cell death & disease

Wang Y,Gao P,Wei C,Li H,Zhang L,Zhao Y,Wu B,Tian Y,Zhang W,Wu L,Wang R,Xu C

Thu May 18 00:00:00 EDT 2017

Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization.

Cell death and differentiation

Li H,Ruan Y,Zhang K,Jian F,Hu C,Miao L,Gong L,Sun L,Zhang X,Chen S,Chen H,Liu D,Song Z

Tue Mar 01 00:00:00 EST 2016

Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization.

Cell death and differentiation

Li H,Ruan Y,Zhang K,Jian F,Hu C,Miao L,Gong L,Sun L,Zhang X,Chen S,Chen H,Liu D,Song Z

Tue Mar 01 00:00:00 EST 2016

Oral quercetin administration transiently protects respiratory function in dystrophin-deficient mice.

The Journal of physiology

Selsby JT,Ballmann CG,Spaulding HR,Ross JW,Quindry JC

Sat Oct 15 00:00:00 EDT 2016

Oral quercetin administration transiently protects respiratory function in dystrophin-deficient mice.

The Journal of physiology

Selsby JT,Ballmann CG,Spaulding HR,Ross JW,Quindry JC

Sat Oct 15 00:00:00 EDT 2016

COA7 (C1orf163/RESA1) mutations associated with mitochondrial leukoencephalopathy and cytochrome c oxidase deficiency.

Journal of medical genetics

Martinez Lyons A,Ardissone A,Reyes A,Robinson AJ,Moroni I,Ghezzi D,Fernandez-Vizarra E,Zeviani M

Thu Dec 01 00:00:00 EST 2016

COA7 (C1orf163/RESA1) mutations associated with mitochondrial leukoencephalopathy and cytochrome c oxidase deficiency.

Journal of medical genetics

Martinez Lyons A,Ardissone A,Reyes A,Robinson AJ,Moroni I,Ghezzi D,Fernandez-Vizarra E,Zeviani M

Thu Dec 01 00:00:00 EST 2016

CYC1 Predicts Poor Prognosis in Patients with Breast Cancer.

Disease markers

Han Y,Sun S,Zhao M,Zhang Z,Gong S,Gao P,Liu J,Zhou J,Ma D,Gao Q,Wu P

Mon Feb 20 00:00:00 EST 2017

CYC1 Predicts Poor Prognosis in Patients with Breast Cancer.

Disease markers

Han Y,Sun S,Zhao M,Zhang Z,Gong S,Gao P,Liu J,Zhou J,Ma D,Gao Q,Wu P

Mon Feb 20 00:00:00 EST 2017

Exercise Inducible Lactate Dehydrogenase B Regulates Mitochondrial Function in Skeletal Muscle.

The Journal of biological chemistry

Liang X,Liu L,Fu T,Zhou Q,Zhou D,Xiao L,Liu J,Kong Y,Xie H,Yi F,Lai L,Vega RB,Kelly DP,Smith SR,Gan Z

Fri Dec 02 00:00:00 EST 2016

Exercise Inducible Lactate Dehydrogenase B Regulates Mitochondrial Function in Skeletal Muscle.

The Journal of biological chemistry

Liang X,Liu L,Fu T,Zhou Q,Zhou D,Xiao L,Liu J,Kong Y,Xie H,Yi F,Lai L,Vega RB,Kelly DP,Smith SR,Gan Z

Fri Dec 02 00:00:00 EST 2016

EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer.

The EMBO journal

Zhang J,Wang C,Chen X,Takada M,Fan C,Zheng X,Wen H,Liu Y,Wang C,Pestell RG,Aird KM,Kaelin WG,Liu XS,Zhang Q

Wed Dec 02 00:00:00 EST 2015

EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer.

The EMBO journal

Zhang J,Wang C,Chen X,Takada M,Fan C,Zheng X,Wen H,Liu Y,Wang C,Pestell RG,Aird KM,Kaelin WG,Liu XS,Zhang Q

Wed Dec 02 00:00:00 EST 2015

Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1.

Nature communications

Ma X,Li C,Sun L,Huang D,Li T,He X,Wu G,Yang Z,Zhong X,Song L,Gao P,Zhang H

Fri Oct 10 00:00:00 EDT 2014

Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1.

Nature communications

Ma X,Li C,Sun L,Huang D,Li T,He X,Wu G,Yang Z,Zhong X,Song L,Gao P,Zhang H

Fri Oct 10 00:00:00 EDT 2014

Bioinformatics

Protein Aliases: Flavoprotein subunit of complex II; Fp; Malate dehydrogenase [quinone] flavoprotein subunit; succinate dehydrogenase [ubiquinone] flavoprotein subunit; Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; succinate dehydrogenase complex subunit A, flavoprotein (Fp); succinate dehydrogenase complex, subunit A, flavoprotein (Fp)

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Gene Aliases: 1500032O14Rik; 2310034D06Rik; 4921513A11; C81073; CMD1GG; FP; PGL5; SDH1; SDH2; SDHA; SDHF

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UniProt ID: (Human) Q59GW8, (Rat) Q920L2, (Mouse) Q8K2B3

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Entrez Gene ID: (Human) 6389, (Rat) 157074, (Mouse) 66945

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Function(s)

succinate dehydrogenase activity protein binding succinate dehydrogenase (ubiquinone) activity flavin adenine dinucleotide binding oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors dehydrogenase oxidoreductase metabolite interconversion enzyme

Process(es)

tricarboxylic acid cycle succinate metabolic process nervous system development respiratory electron transport chain oxidation-reduction process transport electron transport chain

Performance Guarantee

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SDHA Polyclonal Antibody

SDHA Antibody (14865-1-AP) in ICC/IF

Product Details

14865-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

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