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Standard Single-Use BioProcess Containers (BPCs)
BPCs are ready-to-use, single-use flexible container systems commonly for critical sterile liquid-handling applications in the biopharmaceutical industry.
BPC systems are cost-effective alternatives to conventional stainless steel systems. They employ a novel design approach that helps increase shop-floor productivity. BPC components are readily integrated into a variety of high-performance systems for all steps in the production of biologics.
Definitions and applications for BPCs
The three main types of BPCs are highlighted below, which are Thermo Scientific 2D Labtainer and 3D Productainer BPCs, and tank liners. Specialty BPCs are also available for specific applications and use in bioprocess equipment.
2D Labtainer BPC systems
This is the design for small, simple BPCs from 50 mL to 50 L. Labtainers are produced from two sheets of film that are heat-sealed around the perimeter to form a pillow-shaped chamber. The ports are heat-sealed into the end seal or onto one of the chamber’s film panels.
3D Productainer BPC systems
This design is used for larger and more complicated BPCs. A square tube is formed by heat-sealing 4 sheets of film together. Top-, and bottom-porting options are available in a range of sizes from 50 L to 5000 L, with a greater degree of chamber complexity.
Tank Liner BPC systems
This design is used for non-sterile operations including mixing and waste collection. Tank liners remove the need for tank cleaning and help reduce cycle times. Tank liners are optimized for use with Thermo Scientific drums and cylindrical tanks.
The main components of a BPC chamber are the ports that enable tubing to be attached to the chamber. There are a number of different port designs depending on the type of chamber.
All BPC chambers and related components are produced in an ISO 7–certified cleanroom at our manufacturing facilities. Additional components are then attached to the BPC chamber to produce a complete BPC. BPC assembly is a process that provides the ability to produce customized BPC assemblies for all operations in the biologics or vaccines workflow. Thermo Scientific fluid transfer assemblies are also produced to complement BPC systems. Final assembly is done under the same controlled environment and to the same level of quality.
Each lot of BPCs is 100% visually inspected against product specifications, and packaged and sealed in two independent outer dust covers while still in the ISO 7–certified area. They are then placed in cardboard cartons labeled with product and lot identification.
Thermo Scientific films are engineered to meet the most demanding requirements of your bioproduction processes.
Choose between:
- Aegis5-14 film—for high-value applications
- CX5-14 film—one of the most widely used films in the industry, proven over 10 years
- ASI 26/77 film—a two-layered film, for a variety of workflow applications
- ASI 28 film—a robust, four-layer film for specific unit operations
- CX3-9 film—a three-layered film with a polyester elastomer coextruded outer layer with a low-density polyethylene product contact layer
- ASI 26 film—a single-layer film with good toughness and puncture resistance ASI 77 film—a single-web film constructed from nylon with an ethylene vinyl alcohol EVOH barrier layer and a linear low-density polyethylene (LLDPE) layer
The three main types of BPCs are highlighted below, which are Thermo Scientific 2D Labtainer and 3D Productainer BPCs, and tank liners. Specialty BPCs are also available for specific applications and use in bioprocess equipment.
2D Labtainer BPC systems
This is the design for small, simple BPCs from 50 mL to 50 L. Labtainers are produced from two sheets of film that are heat-sealed around the perimeter to form a pillow-shaped chamber. The ports are heat-sealed into the end seal or onto one of the chamber’s film panels.
3D Productainer BPC systems
This design is used for larger and more complicated BPCs. A square tube is formed by heat-sealing 4 sheets of film together. Top-, and bottom-porting options are available in a range of sizes from 50 L to 5000 L, with a greater degree of chamber complexity.
Tank Liner BPC systems
This design is used for non-sterile operations including mixing and waste collection. Tank liners remove the need for tank cleaning and help reduce cycle times. Tank liners are optimized for use with Thermo Scientific drums and cylindrical tanks.
The main components of a BPC chamber are the ports that enable tubing to be attached to the chamber. There are a number of different port designs depending on the type of chamber.
All BPC chambers and related components are produced in an ISO 7–certified cleanroom at our manufacturing facilities. Additional components are then attached to the BPC chamber to produce a complete BPC. BPC assembly is a process that provides the ability to produce customized BPC assemblies for all operations in the biologics or vaccines workflow. Thermo Scientific fluid transfer assemblies are also produced to complement BPC systems. Final assembly is done under the same controlled environment and to the same level of quality.
Each lot of BPCs is 100% visually inspected against product specifications, and packaged and sealed in two independent outer dust covers while still in the ISO 7–certified area. They are then placed in cardboard cartons labeled with product and lot identification.
Thermo Scientific films are engineered to meet the most demanding requirements of your bioproduction processes.
Choose between:
- Aegis5-14 film—for high-value applications
- CX5-14 film—one of the most widely used films in the industry, proven over 10 years
- ASI 26/77 film—a two-layered film, for a variety of workflow applications
- ASI 28 film—a robust, four-layer film for specific unit operations
- CX3-9 film—a three-layered film with a polyester elastomer coextruded outer layer with a low-density polyethylene product contact layer
- ASI 26 film—a single-layer film with good toughness and puncture resistance ASI 77 film—a single-web film constructed from nylon with an ethylene vinyl alcohol EVOH barrier layer and a linear low-density polyethylene (LLDPE) layer
Specialty BioProcess Containers
The innovative design concept of the Thermo Scientific Labtainer Pro BioProcess Container (BPC) provides flexibility and assurance-without compromise.
The Harvestainer BPC is a closed, single-use solution for harvesting and separating cell cultures grown on microcarrier beads.
The Powdertainer II BPC is specifically designed for powder containment and dust-free powder transfer operations.
The Three60 Sampling System allows you to take samples of your product with minimal effort in a closed system.
CentriPAK BioProcess Container
Next-generation centrifuge-ready BioProcess Containers provide a single-use, sterilized, closed system for cell harvesting in BioProcessing.
How to Videos: BioProcess Container (BPC) unpacking and installation
Unpacking and installation of Thermo Scientific BioProcess Container (BPC) (1/2)This video is part 1 of 2 videos that covers the Thermo Scientific BioProcess Containers unpacking and inspection. The video will cover both 2D and 3D BPCs, manifolds, and tubing assemblies. It is based on the BPC Unpacking and Inspection Guide.
Unpacking and installation of Thermo Scientific BioProcess Container (BPC) (2/2)This video is part 1 of 3 videos that covers the HyPerforma 5:1 Single-Use Bioreactor (S.U.B.) setup and installation. It is based on the HyPerforma 5:1 S.U.B. User’s Guide. Please refer to the guide for detailed instructions.
Ordering Information
2D Labtainers
3D Productainers
Tank Liners and Accessories
Related resources
Standard Bioprocess Containers (BPCs)
Bioprocessing resources
Access a targeted collection of scientific application notes, case studies, posters, white papers and more for bioprocessing: