Itraconazole, 99%

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Itraconazole, 99%

Name: Itraconazole, 99%
SKU: 452870050
Price: 125.65 USD

Itraconazole, or voriconazole, CAS # 84625-61-6, is an N-arylpiperazine that has antifungal properties. | CAS: 84625-61-6 | C35H38Cl2N8O4 | 705.64 g/mol

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Catalog number 452870050

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Price (USD)

125.65

Online Exclusive

139.00

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Each

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Chemical Identifiers

CAS84625-61-6

IUPAC Name1-(butan-2-yl)-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-[(1H-1,2,4-triazol-1-yl)methyl]-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-4,5-dihydro-1H-1,2,4-triazol-5-one

Molecular FormulaC35H38Cl2N8O4

InChI KeyVHVPQPYKVGDNFY-ZPGVKDDISA-N

SMILESCCC(C)N1N=CN(C1=O)C1=CC=C(C=C1)N1CCN(CC1)C1=CC=C(OC[C@H]2CO[C@@](CN3C=NC=N3)(O2)C2=CC=C(Cl)C=C2Cl)C=C1

Specifications

Specification Sheet

Melting point165°C to 169°C

Appearance (Color)White to almost white

Appearance (Form)Powder

Infrared spectrumConforms

HPLC>=98.5 %

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Itraconazole is an aromatic ether that works as a strong inhibitor of P-glycoproteins and CYP3A4

• Itraconazole also acts as a hedgehog signaling inhibitor and P450 inhibitor

Applications

• Itraconazole can be exhibits antifungal activity against organisms including aspergillosis, blastomycosis, candidiasis, chromoblastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, and sporotrichosis

• Itraconazole may be used to experimentally target the delivery of other molecules, such as plasmids, to cells

RUO – Research Use Only

General References:

Sharma, P.; Bhalla, M.; Thami, G.P.; Chander, J. Evaluation of efficacy and safety of oral terbinafine and itraconazole combination therapy in the management of dermatophytosis. J Dermatolog Treat. 2020, 31(7), 749-753.
Hamed Khater, M.; Khattab, F.M. Combined long-pulsed Nd-Yag laser and itraconazole versus itraconazole alone in the treatment of onychomycosis nails. J Dermatolog Treat. 2020, 31(4), 406-409.

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