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Application
FIGURE: 1 / 3
MYO5A Antibody (55318-1-AP150UL) in IHC (P)
Immunohistochemical analysis of paraffin-embedded Mouse brain tissue slide using (Product # 55318-1-AP150UL) (MYO5A antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).
Product Details
55318-1-AP150UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Conjugate
Unconjugated
Form
Liquid
Concentration
1.5 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Target Information
This gene is one of three myosin V heavy-chain genes, belonging to the myosin gene superfamily. Myosin V is a class of actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation. The protein encoded by this gene is abundant in melanocytes and nerve cells. Mutations in this gene cause Griscelli syndrome type-1 (GS1), Griscelli syndrome type-3 (GS3) and neuroectodermal melanolysosomal disease, or Elejalde disease. Multiple alternatively spliced transcript variants encoding different isoforms have been reported, but the full-length nature of some variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dilute lethal-20J protein; Dilute myosin heavy chain, non-muscle; dilute-opisthotonus; flailer; myosin 5a; Myosin heavy chain 12; myosin V; myosin VA (heavy chain 12, myoxin); myosin, heavy polypeptide kinase; Myosin-12; myosin-Va; Myoxin; OTTMUSP00000017756; OTTMUSP00000019176; OTTMUSP00000046608; Unconventional myosin-Va
Gene Aliases: 9630007J19Rik; AI413174; AI661011; D; d-120J; Dbv; Dilute; Dop; flail; flr; GS1; MVa; MYH12; MYO5; MYO5A; MyoVA; MYR12; Sev-1
UniProt ID: (Human) Q9Y4I1, (Mouse) Q99104, (Rat) Q9QYF3
Entrez Gene ID: (Human) 4644, (Mouse) 17918, (Rat) 25017
microfilament motor activity
actin binding
calcium ion binding
calmodulin binding
ATP binding
Rab GTPase binding
poly(A) RNA binding
SNARE binding
nucleotide binding
motor activity
protein binding
syntaxin-1 binding
ATP-dependent protein binding
protein heterodimerization activity
protein dimerization activity
calcium-dependent protein binding
actin binding motor protein
transport
exocytosis
post-Golgi vesicle-mediated transport
chemical synaptic transmission
visual perception
vesicle-mediated transport
actin filament-based movement
vesicle transport along actin filament
insulin secretion
melanocyte differentiation
regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
locomotion involved in locomotory behavior
secretory granule localization
melanosome transport
cellular response to insulin stimulus
odontogenesis
myelination
long-chain fatty acid biosynthetic process
synapse organization
endoplasmic reticulum localization
protein localization to plasma membrane
regulation of Golgi organization
melanin metabolic process
metabolic process
protein transport
regulation of exocytosis
melanosome localization
anagen
pigmentation
developmental pigmentation
neuromuscular process controlling balance
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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