TMT™ Elution Buffer and Anti-TMT Resin
TMT™ Elution Buffer and Anti-TMT Resin
TMT™ Elution Buffer and Anti-TMT Resin
TMT™ Elution Buffer and Anti-TMT Resin
Thermo Scientific™

TMT™ Elution Buffer and Anti-TMT Resin

For enhanced enrichment, use Thermo Scientific TMT Elution Buffer with Immobilized Anti-TMT Resin for peptides that have been chemically labeled with Tandem Mass Tag (TMT) Isobaric Label Reagents for multiplexed protein quantitation using tandem mass spectrometry.
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Catalog NumberQuantityProduct Type
900766 mLImmobilized Anti-TMT™ Antibody Resin
9010420 mLTMT™ Elution Buffer
Catalog number 90076
Price (USD)
707.20
Special offer
Online exclusive
Ends: 15-Aug-2025
832.00
Save 124.80 (15%)
Each
In stock
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Quantity:
6 mL
Product Type:
Immobilized Anti-TMT™ Antibody Resin
Recurring order eligible. Learn more »
Price (USD)
707.20
Special offer
Online exclusive
Ends: 15-Aug-2025
832.00
Save 124.80 (15%)
Each
Add to cart
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Tandem mass tag (TMT) isobaric label reagents are used for multiplexed protein quantitation using tandem mass spectrometry. Immobilized Anti-TMT Resin is designed to effectively capture and enrich peptides or proteins labeled using any TMT reagent. Anti-TMT Resin and TMT Elution Buffer are effective for reducing sample complexity, improving dynamic range, and studying cysteine modifications such as S-nitrosylation, oxidation, and disulfide bonds of protein samples labeled with iodoTMT reagents.

Tandem mass tag (TMT) reagents are used to chemically label proteins in different samples for multiplexed quantitation using tandem mass spectrometry. Immobilized Anti-TMT Resin contains an agarose-immobilized anti-TMT monoclonal antibody and is effective for capture and enrichment of peptides or proteins labeled using any TMT reagent. This helps simplify otherwise complex samples before LC-MS/MS analysis, especially when the targets for labeling are rare (e.g., cysteine sulfhydryls). Enrichment of labeled peptides by this method results in fewer peptides identified per protein, but can significantly increase the number of unique proteins identified, making it easier to detect and measure low-abundance proteins.

Immobilized Anti-TMT Resin uses our highly specific Anti-TMT Antibody (Cat. No. 90075) to bind peptides labeled with TMT reagents. The antibody is specific for the mass reporter region of the TMT reagents, which allows for enrichment of TMT-labeled peptides regardless of peptide labeling chemistry (e.g., amine-reactive, sulfhydryl-reactive). TMT Elution Buffer is a volatile neutral buffer that competitively elutes captured TMT-labeled peptides. When used in combination with Immobilized Anti-TMT Resin, TMT Elution Buffer provides higher specific enrichment of TMT-labeled peptides compared to acidic or basic elution buffers.

Enrichment features include:
Specific—uses specific, high-affinity antibody for the TMT structure (Kd >100 pM)
Compatible—effective for all varieties of TMT reagents (amine-reactive or cysteine-reactive)
Versatile—use resin with TMT Elution Buffer for optimal sample enrichment

For Research Use Only. Not for use in diagnostic procedures.
Specifications
Label or DyeTandem Mass Tag™ (TMT) Labels
Quantity6 mL
Workflow StepProtein Labeling
Detection MethodMass Spectrometry
Product LineTMT™
Product TypeImmobilized Anti-TMT™ Antibody Resin
Starting MaterialCell Lysate
Unit SizeEach
Contents & Storage
Upon receipt store all products at 4°C. Product shipped with an ice pack.
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Lot #Certificate TypeDateCatalog Number(s)
3214215Certificate of AnalysisMay 20, 202590076
ZL402626Certificate of AnalysisFeb 12, 202590076, 90076TS
ZH378651Certificate of AnalysisSep 13, 202490076
ZF38650Certificate of AnalysisJun 14, 202490076
YL384222Certificate of AnalysisJan 25, 202490104
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