TheraPure™ GMP Eam1104I Restriction Enzyme, 20 U/μL
TheraPure™ GMP Eam1104I Restriction Enzyme, 20 U/μL
Thermo Scientific™

TheraPure™ GMP Eam1104I Restriction Enzyme, 20 U/μL

Thermo Scientific TheraPure GMP* Eam1104I Restriction Enzyme is manufactured to ICH Q7 GMP principles and supported by comprehensive documentation package.Read more
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Catalog NumberQuantity
ER023BB0074000 kU
ER023SKB004100 kU
ER023SKB0051000 kU
Catalog number ER023BB007
Price (USD)
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Quantity:
4000 kU
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Thermo Scientific TheraPure GMP* Eam1104I Restriction Enzyme is manufactured to ICH Q7 GMP principles and supported by comprehensive documentation package. It is a Type IIS restriction endonuclease (isoschizomers: Bst6I, EarI) designed for DNA template linearization that recognizes and cleaves DNA at:

5'  C  T  C  T  T  C  N      3' 
3'  G  A  G  A  A  G  N  N  N  N   5' 

Designed for process development and manufacturing
TheraPure GMP Eam1104I Restriction Enzyme helps accelerate mRNA vaccine and therapeutics production from preclinical development to commercialization by providing:
Quality—meet critical product quality needs to help accelerate therapeutic development and manufacturing
Minimal risk—helps reduce risks in developing therapeutics by utilizing proven products
Technical partnership—partner with expert product and technical support
Secure and consistent supply—count on a secure and stable supply of product at a global scale

Comprehensive quality system
TheraPure GMP Eam1104I Restriction Enzyme is supported by a extensive quality system and documentation including:
• Manufactured to relevant ICH Q7 GMP guidelines
• Animal-origin free (AOF) manufacturing processes, materials, and facilities
• Validated manufacturing processes and analytical test methods
• Comprehensive impurity profiles
• Verified compendial assays where applicable
• Product stability data
• Tested by analytical methods following ICH Q2 guidelines whenever possible
• Drug master file (DMF)

Full enzyme activity in recommended buffers
TheraPure GMP Eam1104I Restriction Enzyme exhibits 100% activity in the recommended buffer and reaction conditions. To help ensure consistent performance, Thermo Scientific restriction enzyme reaction buffers contain premixed rBSA, which helps enhance the stability of enzyme.

Enzyme activity
One unit is defined as the amount of enzyme required to digest 1 μg of lambda DNA or plasmid in 1 hour at 37°C in 50 μL of assay buffer.

For additional TheraPure GMP products or customization, please visit www.thermofisher.com/therapure.

*TheraPure GMP refers to the quality level of the raw, ancillary, or starting materials to be used for further manufacturing. TheraPure GMP products are manufactured in facilities with ISO 9001–certified quality management systems that operate in accordance with relevant good manufacturing practice (GMP) principles, as outlined in ICH Q7 or equivalent guidance documents or standards.

For Research Use or Further Manufacturing. Not for diagnostic use or direct administration into humans or animals.
Specifications
ColorTransparent
Compatible Buffer10X Buffer Tango
Cut SiteCTCTTC(1/4)^
For Use With (Application)DNA template linearization, Plasmid linearization
Product TypeRestriction Enzyme
Quantity4000 kU
SourceEnterobacter Amnigenus gene
Storage Buffer0.2 mg/mL rBSA, 10 mM Tris-HCl, pH 7.4, 1 mM EDTA, 100 mM KCl, 1 mM DTT, 50% glycerol
Concentration20 U/μL
EnzymeEam1104I
FormLiquid
Methylation SensitivityNot Dam Methylation-Sensitive, Not Dcm Methylation-Sensitive, Not CpG Methylation-Sensitive
Optimal Reaction Temperature37°C
Product LineTheraPure™ GMP
Sensitive to Heat InactivationYes
Type IIS REYes
pH7 to 7.8
Unit SizeEach
mRNA services

Access customized materials for producing RNA therapeutics

To help drug developers obtain materials that are not available off the shelf, we offer world-class capabilities to develop and manufacture raw materials (e.g., nucleotides, enzymes) for producing nucleic acid therapeutics.

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