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Human Plateable Hepatocytes, Transporter Qualified
Plateable cryopreserved human hepatocytes assessed for transporter function using uptake transporter assays at both 4°C and 37°C. Cells per vial:Read more
| Catalog Number | Quantity |
|---|---|
| HMCPTS | 1.5 mL vial |
Catalog number HMCPTS
Price (USD)
2,620.00
Each
In stock
Quantity:
1.5 mL vial
Price (USD)
2,620.00
Each
Plateable cryopreserved human hepatocytes assessed for transporter function using uptake transporter assays at both 4°C and 37°C.
Cells per vial: 4-8 million
Hepatocyte cultures were incubated with taurocholate and estradiol 17β glucuronide (E2-17G), substrates of the uptake and efflux transporters NTCP/BSEP and OATPs/MRP2. Accumulation rates and facilitated active uptake were calculated.
Get the Results You Need with GIBCO Hepatocytes
High quality hepatocytes, with high viabilities, proper cell morphology, and transporter function increase the ability to draw in vitro⁄in vivo correlations and make sound decisions regarding a compound's fate. Experienced technicians and proprietary isolation techniques combined with stringent release specifications ensure you receive the highest quality cryopreserved hepatocytes.
Each lot is tested for:
• Viability ≥ 70%
• Attachment efficiency
• Monolayer formation and integrity
• Confluency >80% on Day 4
• Tested for plating in 96 well format
• Phase I enzyme activities
• Transporter activity
• Bile canaliculi formation
• Relevant CYP450 polymorphisms
Related Links:
Learn more about our cryopreserved hepatocytes
Learn about our full line of hepatocytes ,
Note:
These products require shipment in LN2 vapor dewars therefore additional fees may apply.
Cells per vial: 4-8 million
Hepatocyte cultures were incubated with taurocholate and estradiol 17β glucuronide (E2-17G), substrates of the uptake and efflux transporters NTCP/BSEP and OATPs/MRP2. Accumulation rates and facilitated active uptake were calculated.
Get the Results You Need with GIBCO Hepatocytes
High quality hepatocytes, with high viabilities, proper cell morphology, and transporter function increase the ability to draw in vitro⁄in vivo correlations and make sound decisions regarding a compound's fate. Experienced technicians and proprietary isolation techniques combined with stringent release specifications ensure you receive the highest quality cryopreserved hepatocytes.
Each lot is tested for:
• Viability ≥ 70%
• Attachment efficiency
• Monolayer formation and integrity
• Confluency >80% on Day 4
• Tested for plating in 96 well format
• Phase I enzyme activities
• Transporter activity
• Bile canaliculi formation
• Relevant CYP450 polymorphisms
Related Links:
Learn more about our cryopreserved hepatocytes
Learn about our full line of hepatocytes ,
Note:
These products require shipment in LN2 vapor dewars therefore additional fees may apply.
For Research Use Only. Not for use in diagnostic procedures.
Specifications
Donor SourceSingle Donor
No. of Cells4-8 x 106
Product LineGibco™
Product TypeHepatocytes
Quantity1.5 mL vial
Cell LinePrimary
Cell TypeHepatocytes
Culture TypeHepatocyte Cell Culture
FormCryopreserved
SpeciesHuman
TissueLiver
Unit SizeEach
Contents & Storage
Store in a cryostorage dewar or -135°C freezer.
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Figures
2D Sandwich Culture of Transporter Qualified Hepatocytes
Evaluation of Bile Duct Formation in Transporter Qualified Hepatocytes
Transporter Uptake Activity of Transporter Qualified Hepatocytes
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Safety Data Sheets
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Product Information
Frequently asked questions (FAQs)
Our hepatocytes are prequalified and sold according to application, such as induction, short-term metabolism, and transporter uptake. If you require hepatocytes with particular P450 values or donor specifications, contact our Hepatic Biology Tech Support Team (hepaticproducts@thermofisher.com.com) or (866) 952-3559 to help with specific lot recommendations.
Thermo Fisher Scientific has a dedicated team to answer questions regarding hepatocyte cell culture. You can send a question by email (hepaticproducts@thermofisher.com) or contact us by phone: US toll-free: (866) 952-3559
Thermofisher Scientific works with a variety of human tissue sources, including Tissue and Organ Procurement Organizations, qualified Research Tissue Organizations and prominent academic and medical centers through collaborations that follow rigorous regulations, certifications and/or accreditations (“Source Facilities”). Tissues obtained through source facilities are consistent with the applicable legal and ethical practices of the United States.
Source Facilities are required by federal law to maintain accurate records and donor confidentiality as well as adhere to certain applicable laws governing tissue used for research globally. These include, but are not limited to:
- 45 CFR Part 46, subparts A, B, C, D where applicable (US federal guidance on the use of human subjects in research)
- Health Insurance Portability and Accountability Act (HIPAA) (addressing issues of confidentiality of personal information)
- National Organ Transplant Act (42 CFR Part 482)
- The Uniform Anatomical Gift Act (UAGA) of 1968, revised 1984
The human liver cells are derived from tissue obtained from accredited institutions. Consent is obtained by these institutions from the donor or the donor’s legal next of kin, for the use of the tissue and its derivatives for research purpose.
Hepatocytes need to be plated on collagen I-coated culture vessels.
Find additional tips, troubleshooting help, and resources within our Cell Culture Support Center.