Cycloheximide, 95%

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Cycloheximide, 95%

Name: Cycloheximide, 95%
SKU: 357420250
Price: 812.60 EUR

Cycloheximide, CAS # 66-81-9, is a compound produced by the bacterium Streptomyces griseus that shows an antifungal antibiotic activity with the ability to inhibit protein synthesis only in eukaryotic cells.

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Catalog Number	Quantity
357420250	25g
357420010	1g
357420050	5g

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Catalog number 357420250

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812,60

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Quantity:

25g

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Price (EUR)

812,60

Online Exclusive

956,00

Save 143,40 (15%)

Each

Add to cart

Chemical Identifiers

CAS66-81-9

IUPAC Name4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione

Molecular FormulaC15H23NO4

InChI KeyYPHMISFOHDHNIV-QTEFRXOUNA-N

SMILES[H][C@]1(C[C@@H](C)C[C@H](C)C1=O)[C@H](O)CC1CC(=O)NC(=O)C1

Specifications

Specification Sheet

Appearance (Color)White to light beige

Specific optical rotation-25° to -32° (20°C, 589 nm) (c=1, CHCl3)

Melting point108°C to 118°C

HPLC>=94 %

Infrared spectrumConforms

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

Cycloheximide is a semisynthetic compound showing an antifungal antibiotic activity.
It is produced by the bacterium Streptomyces griseus
Cycloheximide can inhibit protein synthesis in eukaryotic cells but not in prokaryotes by interacting directly with the translocase enzyme and interfering with the translocation step. Furthermore, this compound also blocks the A site of ribosomes

Application

Cycloheximide shows a neuroprotective, fungicide, and anticoronaviral activities
In biomedical research, it can induce glycogenolysis, gluconeogenesis, and ureagenesis
Due to significant toxic side effects such as teratogenesis, DNA damage, birth defects, and toxicity to sperm, this chemical compound is only used in in vitro research applications
This compound also shows inhibitory activity against ferroptosis
It is also used in laboratory media as a selective agent to permit the isolation of pathogenic and non-pathogenic fungi from other types of specimens
In laboratory research related to plant biology, it can induce ethylene production to promote the plant growth
In laboratory research, this compound can be applied to determine the half-life of protein in any cellular system. The treatment of in vitro cells with cycloheximide in a time-course experiment followed by western blotting using this cell lysate can show differences in protein half-life.

RUO – Research Use Only

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