General description

• Fluoxymesterone is a white, odorless, crystalline powder, soluble in pyridine
• It is an orally-administered synthetic steroid that is about 5-10 times more potent than male steroid, testosterone
• It is metabolized in the liver, and less than 5% of this drug is excreted from the body unchanged
• Adverse effects of fluoxymesterone include sodium and water retention leading to edema, acne, cardiovascular toxicity, and hepatotoxicity

Applications

• Fluoxymesterone has been found to competitively inhibit prolactin or estrogen receptors in tumorigenic breast cells, and is therefore administered in the treatment of breast cancer
• In males, this compound is used as a replacement in conditions associated with symptoms of deficiency or absence of endogenous testosterone