General Information

• Nitrilotriacetic acid, trisodium salt, monohydrate is considered to be a nongenotoxic compound with carcinogenic activity
• This compound inhibits gap-junctional communication between Chinese hamster lung fibroblasts

Applications

• Nitrilotriacetic acid trisodium salt monohydrate is commonly used in laboratory experiments due to its capacity to induce the tumorigenic process
• It has been used in in vivo experiments as an inducer of bladder and kidney tumors in animal models
• It is used as a chelating agent, which forms coordination compounds with metal ions (chelates)

Literature References
Malcolm, A.; Mills, L. Inhibition of gap-junctional intercellular communication between Chinese hamster lung fibroblasts by di(2-ethylhexyl) phthalate (DEHP) and trisodium nitrilotriacetate monohydrate (NTA). Cell Biology and Toxicology. 1989, 5, 145–153.