Bafilomycin A1, 95%

Bafilomycin A1, CAS # 88899-55-2, is an inhibitor of vacuolar ATPases from Streptomyces griseus that has antibacterial, antifungal, and antineoplastic activity. | CAS: 88899-55-2 | C35H58O9 | 622.84 g/mol

製品番号（カタログ番号）	数量
328120001	0.1 mg

製品番号（カタログ番号） 328120001

価格（JPY）

見積もりを依頼する

0.1 mg

一括またはカスタム形式をリクエストする

化学物質識別子

CAS88899-55-2

IUPAC Name(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-16-[(2S,3R,4S)-4-[(2R,4R,5S,6R)-2,4-dihydroxy-5-methyl-6-(propan-2-yl)oxan-2-yl]-3-hydroxypentan-2-yl]-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-1-oxacyclohexadeca-3,5,11,13-tetraen-2-one

Molecular FormulaC35H58O9

InChI KeyXDHNQDDQEHDUTM-JQWOJBOSSA-N

SMILESCO[C@H]1\C=C\C=C(C)\C[C@H](C)[C@H](O)[C@H](C)\C=C(/C)\C=C(OC)\C(=O)O[C@@H]1[C@@H](C)[C@@H](O)[C@H](C)[C@@]1(O)C[C@@H](O)[C@H](C)[C@H](O1)C(C)C

さらに表示

HPLC>=94 %

Appearance (Color)White to off-white

Appearance (Form)Powder or solid

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

Bafilomycin A1 is a specific potent inhibitor of vacuolar ATPases
It is a macrolide antibiotic, and shows fungicide activity

Application

Bafilomycin A1 has antibacterial, antifungal, and antineoplastic activity
It can be immunosuppressive
It can prevent maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes
It is a potent and selective inhibitor of vacuolar-type H+ ATPase (V-ATPase)

RUO – Research Use Only

General References:

Miao, Y.; Li, G.; Zhang, X.; Xu, H.; Abraham, S. N. A TRP Channel Senses Lysosome Neutralization by Pathogens to Trigger Their Expulsion. Cell. 2015, 161 (6), 1306-1319.
Lee, K. I.; Kim, M. J.; Koh, H.; Lee, J. I.; Namkoong, S.; Oh, W. K.; Park, J.The anti-hypertensive drug reserpine induces neuronal cell death through inhibition of autophagic flux. Biochem. Biophys. Res. Commun. 2015, 462 (4), 402-408.