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Overview
(U)HPLC columns optimized for your analytical performance
Solve your separation challenges with our HPLC and UHPLC columns for small molecules. Our popular product lines of Hypersil GOLD and Accucore columns are designed for a wide range of applications and offer the following features:
- High-resolution HPLC and UHPLC columns
- Built on a 40-year legacy of innovation
- Unmatched variety of stationary phase chemistries, particle sizes, and column formats
- Long column lifetime with reproducible results
- The broadest assortment of solid core columns on the market
From the most commonly-used C18 phases, to innovative chemistries, we have the right column to fulfill your chromatography needs
Meet our (U)HPLC column families
Hypersil GOLD columns
Fully porous for simple samples
Fully porous, ultrapure silica particle columns- Built on 40 years of experience in column development and manufacturing
- Excellent peak symmetry and lot-to-lot reproducibility
- Wide variety of column sizes
Accucore columns
Solid core for high resolution
- Solid core silica technology columns
- UHPLC efficiency on any instrument
- Widest range of chemistries for solid-core particles
Hypersil GOLD HPLC and UHPLC columns
Your first choice of columns for method development
- Built on 40 years of experience in column development and manufacturing
- Offered in a complete range of particle sizes, from HPLC to UHPLC, and a wide range of formats, from micro-flow, to analytical, to semi-preparative
- Able to produce outstanding peak shape, resolution, and lot-to-lot consistency
- Available with several reversed-phase, HILIC, and ion-exchange phases
Explore our complete range of Hypersil GOLD columns to start your chromatography analyses
| Hydrophobic Column Phases | Reversed phase chemistry for separation via hydrophobic interactions. Stationary phases with longer carbon chains provide longer retention times and greater hydrophobicity.
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| Polar-Modified C18 Column Phases | Good for the separation of acidic and basic compounds via reversed phase chromatography using an aqueous mobile phase.
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| Phenyl-Based Column Phases | Orthogonal selectivity to traditional hydrophobic phases that utilizes aromatic interactions to achieve challenging separations of aromatic and polar compounds. Phenyl, PFP |
| Ion-Exchange Column Phases | Ionic and polar compounds are retained via hydrophilic and ionic interactions with a charged stationary phase. Retained compounds can be eluted by changing the solvent conditions of the column.
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| Hydrophilic Columns | Ideal for retaining and separating polar compounds based on polarity differences and affinity for a polar stationary phase. HILIC, Silica |
Learn more about Hypersil GOLD columns
Accucore HPLC and UHPLC columns
Solid core silica particles for high-resolution separation at any pressure
- Rugged, superficially porous particles
- Wide selection of chemistries
- Compatible with any HPLC or UHPLC system
Discover high-throughput columns for rapid (U)HPLC separations
| Hydrophobic Column Phases | Reversed phase chemistry for separation via hydrophobic interactions. Stationary phases with longer carbon chains provide longer retention times and greater hydrophobicity. C18, C8, C4 |
| Specialty Hydrophobic Column Phases | Alternative selectivity to C18 for hydrophobic retention and the geometric separation of structural isomers. RP-MS, C30 |
| Phenyl-Based Column Phases | Orthogonal selectivity to traditional hydrophobic phases that utilizes aromatic interactions to achieve challenging separations of aromatic and polar compounds. Biphenyl, Phenyl-Hexyl, PFP |
| Polar-Modified C18 Column Phases | Good for the separation of acidic and basic compounds via reversed phase chromatography using an aqueous mobile phase Polar Premium, aQ |
| HILIC Column Phases | Ideal for retaining and separating polar compounds based on polarity differences and affinity for a polar stationary phase. HILIC, Amide HILIC |
Phase Name | 1.5 μm | 2.6 μm | 4 μm | Pore Size (Å) | Surface Area (m²/g) | Carbon Load (%) | USP |
— |
| — | 80 | 130 | 9 | L1 | |
| — | — | 80 | 130 | 6.5 | L1 | |
— | — |
| 80 | 130 | 7 | L1 | |
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| — | 80 | 130 | 9 | L7 | |
— | — |
| 80 | 130 | 4 | L7 | |
— |
| — | 150 | 80 | 2 | L26 | |
— |
| — | 80 | 130 | 9 | L1 | |
— |
| — | 80 | 130 | 8 | L60 | |
— |
| — | 80 | 130 | 7 | L1 | |
— |
| — | 80 | 130 | 5 | L62 | |
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| — | 80 | 130 | 6 | L11 | |
— |
| — | 80 | 130 | 5 | L11 | |
— |
| — | 80 | 130 | 5 | L43 | |
— |
| — | 80 | 130 | 6 | – | |
— |
| — | 80 | 130 | – | L3 | |
— |
| — | 150 | 80 | – | – | |
— |
| — | 80 | 130 | – | – |
Learn more about Accucore columns
Resources
HPLC column selection guide
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Know your options
A great resource for getting familiar with and comparing (U)HPLC columns, our Premier Columns Guide contains:
- Overview of column chemistries
- Column comparison chart
- Solid core versus fully porous supports
- Pore size versus surface area
- Quick guide to choosing a stationary phase
- Ordering information
Download premier columns guide
Hypersil GOLD (U)HPLC column literature
Accucore (U)HPLC column literature
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