MANT-GDP (2'-(or-3')-O-(N-Methylanthraniloyl) Guanosine 5'-Diphosphate, Disodium Salt)

MANT-GDP (2'-(or-3')-<i>O</i>-(<i>N</i>-Methylanthraniloyl) Guanosine 5'-Diphosphate, Disodium Salt)

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Citations & References (51)

Invitrogen™

MANT-GDP (2'-(or-3')-O-(N-Methylanthraniloyl) Guanosine 5'-Diphosphate, Disodium Salt)

The nucleotide analog MANT GDP is modified on the ribose moiety. The compact mature of the MANT fluorophore and itsRead more

Catalog Number	Quantity
M12414	400 μL

Catalog number M12414

Price (JPY)

80,700

Quantity:

400 μL

The nucleotide analog MANT GDP is modified on the ribose moiety. The compact mature of the MANT fluorophore and its attachment position results in nucleotide analogs that induce minimal perturbation of nucleotide-protein interactions. Because MANT fluorescence is sensitive to the environment of the fluorophore, nucleotide-protein interactions may be directly detectable. MANT nucleotides are valuable probes of the structure and enzymatic activity of nucleotide-binding proteins.

For Research Use Only. Not for use in diagnostic procedures.

Specifications

Labeling MethodChemical Labeling, Direct Labeling

Label or DyeMANT (N-Methylanthraniloyl)

Product TypeMANT-GDP

Quantity400 μL

Shipping ConditionWet Ice

Concentration5 mM

Unit SizeEach

Contents & Storage

Store in freezer -5°C to -30°C and protect from light.

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Lot #Certificate TypeDateCatalog Number(s)

2633322Certificate of AnalysisApr 04, 2025M12414

2518932Certificate of AnalysisSep 12, 2022M12414

2328983Certificate of AnalysisApr 27, 2021M12414

2298086Certificate of AnalysisJan 27, 2021M12414

2207112Certificate of AnalysisApr 01, 2020M12414

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Safety Data Sheets

SDS

Molecular Probes® Handbook

Probes for Protein Kinases, Protein Phosphatases and Nucleotide-Binding Proteins—Section 17.3

Citations & References (51)

Search citations by name, author, journal title or abstract text

Citations & References

Abstract

Authors:

Journal:

PubMed ID:11063593

The role of Mg2+ cofactor in the guanine nucleotide exchange and GTP hydrolysis reactions of Rho family GTP-binding proteins.

Authors:Zhang B, Zhang Y, Wang Z, Zheng Y

Journal:J Biol Chem

PubMed ID:10843989

'The biological activities of Rho family GTPases are controlled by their guanine nucleotide binding states in cells. Here we have investigated the role of Mg(2+) cofactor in the guanine nucleotide binding and hydrolysis processes of the Rho family members, Cdc42, Rac1, and RhoA. Differing from Ras and Rab proteins, which ... More

Kinetics of Cdc42 membrane extraction by Rho-GDI monitored by real-time fluorescence resonance energy transfer.

Authors:Nomanbhoy TK, Erickson JW, Cerione RA

Journal:Biochemistry

PubMed ID:10026253

'The mechanisms underlying the ability of the Rho-GDP dissociation inhibitor (RhoGDI) to elicit the release of Rho-related GTP-binding proteins from membranes is currently unknown. In this report, we have set out to address this issue by using fluorescence resonance energy transfer approaches to examine the functional interactions of the RhoGDI ... More

Biochemical analysis of SopE from Salmonella typhimurium, a highly efficient guanosine nucleotide exchange factor for RhoGTPases.

Authors:Rudolph MG, Weise C, Mirold S, Hillenbrand B, Bader B, Wittinghofer A, Hardt WD

Journal:J Biol Chem

PubMed ID:10521431

'RhoGTPases are key regulators of eukaryotic cell physiology. The bacterial enteropathogen Salmonella typhimurium modulates host cell physiology by translocating specific toxins into the cytoplasm of host cells that induce responses such as apoptotic cell death in macrophages, the production of proinflammatory cytokines, the rearrangement of the host cell actin cytoskeleton ... More

Alanine scan mutagenesis of the switch I domain of the Caulobacter crescentus CgtA protein reveals critical amino acids required for in vivo function.

Authors:Lin B, Skidmore JM, Bhatt A, Pfeffer SM, Pawloski L, Maddock JR

Journal:Mol Microbiol

PubMed ID:11251813

'The Caulobacter crescentus CgtA protein is a member of the Obg/GTP1 subfamily of monomeric GTP-binding proteins. In vitro, CgtA displays moderate affinity for both GDP and GTP and displays rapid exchange rate constants for either nucleotide, indicating that the guanine nucleotide-binding and exchange properties of CgtA are different from those ... More

51 total citations

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