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Whole Allergen

f300 Goat's milk

f300 Goat's milk Scientific Information

Type:

Whole Allergen

Display Name:

Goat's milk

Other Names:

Goat's milk

Route of Exposure

Main 

Goat's milk, cheese and other dairy products.

Clinical Relevance

IgE-mediated reactions

IgE-mediated reactions have been reported.

Other topic

Goat’s milk often appears as a substitute for cow’s milk, particularly in diets administered by parents to children with atopic dermatitis (1). Some cow’s milk-allergic children may tolerate goat’s milk (2). However, there appears to be evidence for crossreactivity between goat’s milk and cow’s milk (3). In a study of crossreactivity of the casein fractions among different species, the IgE response to ewe and goat’s milk was weaker than that to cow and buffalo (4).

14/16 patients with cow’s milk allergy had specific IgE antibodies to goat’s milk (5). Serum albumin and caseins show homology to the corresponding proteins of cow and sheep (6).

Molecular Aspects

Cross-reactivity

Milk from related animals

Compiled By

Last Reviewed : June 2022

References
  1. Webber, SA; Graham-Brown, RAC; Hutchinson, PE; Burns, DA. Dietary manipulation in childhood atopic dermatitis. Br J Dermatol; 1989; 121: 91-98.
  2. Ellis, MH; Short, J; Heiner, DC. Anaphylaxis after ingestion of a recently introduced hydrolyzed whey protein formula. J Pediatr; 1991; 118: 74-77.
  3. Gjesing, B; Østerballe, O; Schwartz, B; Wahn, U; Løwenstein, H. Allergen-specific IgE antibodies against antigenic components in cow milk and milk substitutes. Allergy; 1986; 41: 51-56.
  4. Bernard, H; Wal, JM; Creminon, C; Grassi, J; Yvon, M; Houdebine, LM. Sensitivities of cow's milk allergic patients to casein fraction of milks from different species. Allergy; 1992; 47: 306.
  5. Dean, TP; Adler, BR; Ruge, F; Warner, JO. In vitro allergenicity of cow's milk substitutes. Clin and Exp Allergy; 1993; 23: 205-210.
  6. Spuergin, P; Walter, M; Schiltz, E; Deichman, K; Forster, J; Mueller. Allergenicity of a -caseins from cow, sheep, and goat. Allergy; 1997; 52: 293-298.