w207 Lupin

w207 Lupin Scientific Information

Type:

Whole Allergen

Display Name:

Lupin

Family:

Fabaceae (Leguminosae)

Latin Name:

Lupinus spp.

Other Names:

Lupin, Lupine

Route of Exposure

Clinical Relevance

IgE mediated reactions

Anecdotal evidence suggests that asthma, allergic rhinitis and allergic conjunctivitis are common following exposure to pollen from Lupin; however, few specific studies have been reported to date. (3)

Molecular Aspects

No allergens from the pollen of this plant have yet been characterised. A number of allergens have been characterised in the seed. However, it has been demonstrated that stress on Lupin could activate a class-III chitinase, IF3. The protein was detected in the seed, leaves and roots. A thaumatin-like protein was also detected. The authors state that ”the ubiquitous presence of this enzyme in healthy, non-stressed tissues of L. albus cannot be explained.” The pollen was not evaluated for the presence of this allergen. (4). A 2S albumin has been isolated from the seed but not from the pollen as yet.(5)

Cross-reactivity

An extensive cross-reactivity among the different individual species of the genus could be expected, as well as to a certain degree among members of the family Fabaceae. (6)

Compiled By

Last reviewed:April 2022

References

Crespo JF, Rodríguez J, Vives R, James JM, Reaño M, Daroca P, et al. Occupational IgE-mediated allergy after exposure to lupine seed flour. The Journal of allergy and clinical immunology. 2001;108(2):295-7.
Parisot L, Aparicio C, Moneret-Vautrin DA, Guerin L. Allergy to lupine flour. Allergy. 2001;56(9):918-9.
Lavaud F, Jonvel AC, Fontaine JF, Sabouraud D, Lebargy F. Les pollinoses de proximité ne sont-elles que des cas cliniques ? Revue de la littérature à propos de cinq observations / Pollinosis of proximity: Review of the literature and report of five cases. Revue francaise d allergologie 2007;41(2):51-6.
Regalado AP, Ricardo CP. Study of the intercellular fluid of healthy Lupinus albus organs. Presence of a chitinase and a thaumatin-like protein. Plant physiology. 1996;110(1):227-32.
Egorov TA, Odintsova TI, Musolyamov A, Fido R, Tatham AS, Shewry PR. Disulphide structure of a sunflower seed albumin: conserved and variant disulphide bonds in the cereal prolamin superfamily. FEBS letters. 1996;396(2-3):285-8.
L. Y. Botanical relations and immunological cross-reactions in pollen allergy. 2nd ed. Pharmacia Diagnostics AB. Uppsala. Sweden. Pharmacia Diagnostics AB Uppsala Sweden. 1982.