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Invitrogen™
Paclitaxel (Taxol Equivalent) - for use in research only
Invitrogen offers paclitaxel for research purposes only at a purity of >98% by HPLC. Paclitaxel, formerly referred to as taxolRead more
| Catalog Number | Quantity |
|---|---|
| P3456 | 5 mg |
Catalog number P3456
Price (USD)
169.65
Online Exclusive
175.00Save 5.35 (3%)
Each
-
Quantity:
5 mg
Price (USD)
169.65
Online Exclusive
175.00Save 5.35 (3%)
Each
Invitrogen offers paclitaxel for research purposes only at a purity of >98% by HPLC. Paclitaxel, formerly referred to as taxol in some scientific literature, is the approved generic name for the anticancer pharmaceutical Taxol (a registered trademark of Bristol-Myers Squibb Co). Paclitaxel promotes tubulin assembly, producing aggregates that cannot be depolymerized by dilution, calcium ions, cold or a number of microtubule-disrupting drugs. Cultured cells treated with paclitaxel are blocked in the G2 and M phases of the cell cycle.
WARNING: Reproductive Harm - www.P65Warnings.ca.gov
For Research Use Only. Not for use in diagnostic procedures.
Specifications
FormLyophilized
InhibitorsCytoskeletal Inhibitor
Quantity5 mg
Shipping ConditionRoom Temperature
Specific Inhibit or TargetTubulin
Product TypePaclitaxel
Unit SizeEach
Contents & Storage
Store in freezer -5°C to -30°C.
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Figures
Bovine pulmonary artery endothelial cells (BPAEC). Paclitaxel, biotin-XX goat anti–mouse IgG and ELF® 97 Cytological Labeling Kit
Mouse fibroblasts. Paclitaxel, biotin-XX goat anti–mouse IgG antibody and ELF® 97 Cytological Labeling Kit
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Lot #Certificate TypeDateCatalog Number(s)
3123565Certificate of AnalysisJan 07, 2025P3456
2738357Certificate of AnalysisOct 30, 2023P3456
2563851Certificate of AnalysisDec 30, 2022P3456
2465115Certificate of AnalysisApr 14, 2022P3456
2421166Certificate of AnalysisOct 18, 2021P3456
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Citations & References (122)
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Citations & References
Abstract
A phase II study of taxol in patients with malignant melanoma.
Journal:Invest New Drugs
PubMed ID:1673965
Based on results of a phase I study demonstrating antitumor activity of taxol in patients with melanoma, 34 patients with documented metastatic melanoma received taxol, 250 mg/m2, as a 24-hours infusion, repeated every 21 days, in this phase II study. All patients received premedication with dexamethasone, diphenhydramine and cimetidine. Four
Regulation of melanosome movement in the cell cycle by reversible association with myosin V.
Journal:J Cell Biol
PubMed ID:10491390
'Previously, we have shown that melanosomes of Xenopus laevis melanophores are transported along both microtubules and actin filaments in a coordinated manner, and that myosin V is bound to purified melanosomes (Rogers, S., and V.I. Gelfand. 1998. Curr. Biol. 8:161-164). In the present study, we have demonstrated that myosin V
Chemical subdomains within the kinetochore domain of isolated CHO mitotic chromosomes.
Journal:J Cell Biol
PubMed ID:1830054
'We have used indirect immunofluorescence in combination with correlative EM to subdivide the mammalian kinetochore into two domains based on the localization of specific antigens. We demonstrate here that the fibrous corona on the distal face of the kinetochore plate contains tubulin (previously shown by Mitchison, T. J., and M.
Targeted disruption of mouse conventional kinesin heavy chain, kif5B, results in abnormal perinuclear clustering of mitochondria.
Journal:Cell
PubMed ID:9657148
'Mouse kif5B gene was disrupted by homologous recombination. kif5B-/- mice were embryonic lethal with a severe growth retardation at 9.5-11.5 days postcoitum. To analyze the significance of this conventional kinesin heavy chain in organelle transport, we studied the distribution of major organelles in the extraembryonic cells. The null mutant cells
Cdc42-interacting protein 4 mediates binding of the Wiskott-Aldrich syndrome protein to microtubules.
Journal:J Biol Chem
PubMed ID:10713100
'The Wiskott-Aldrich syndrome is an inherited X-linked immunodeficiency characterized by thrombocytopenia, eczema, and a tendency toward lymphoid malignancy. Lymphocytes from affected individuals have cytoskeletal abnormalities, and monocytes show impaired motility. The Wiskott-Aldrich syndrome protein (WASP) is a multi-domain protein involved in cytoskeletal organization. In a two-hybrid screen, we identified the
122 total citations