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Invitrogen™
Actinomycin D
Actinomycin D is a nonfluorescent DNA intercalator that exhibits high GC selectivity and causes distortion at its binding site. BindingRead more
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| Catalog Number | Quantity |
|---|---|
| A7592 | 10 mg |
| 11805017 | 5 mg |
Catalog number A7592
Price (EUR)
251,00
Each
-
Quantity:
10 mg
Price (EUR)
251,00
Each
Actinomycin D is a nonfluorescent DNA intercalator that exhibits high GC selectivity and causes distortion at its binding site. Binding of the nonfluorescent actinomycin D to nucleic acids changes the absorbance of the dye. Actinomycin D has been used for chromosome banding studies.
For Research Use Only. Not for use in diagnostic procedures.
Specifications
ColorViolet
Detection MethodColorimetric
Quantity10 mg
Shipping ConditionRoom Temperature
FormSolid
Product TypeAntibiotic
Unit SizeEach
Contents & Storage
Store in freezer (-5 to -30°C) and protect from light.
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Lot #Certificate TypeDateCatalog Number(s)
3163011Certificate of AnalysisMay 11, 202511805017
3124573Certificate of AnalysisApr 09, 202511805017
3093176Certificate of AnalysisFeb 09, 202511805017
3004387Certificate of AnalysisJan 31, 202511805017
2789738Certificate of AnalysisJan 29, 202511805017
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Safety Data Sheets
SDSScientific Resources
Molecular Probes® Handbook
Frequently asked questions (FAQs)
We recommend reconstituting Actinomycin D in either DMF or DMSO; it should be soluble to at least 1 mM in either solvent.
Citations & References (72)
Search citations by name, author, journal title or abstract text
Citations & References
Abstract
Human (MDR1) and mouse (mdr1, mdr3) P-glycoproteins can be distinguished by their respective drug resistance profiles and sensitivity to modulators.
Journal:Biochemistry
PubMed ID:7819214
Possible functional differences between P-glycoproteins (P-gps) encoded by the human MDR1 and mouse mdr1 and mdr3 genes with respect to drug resistance profiles and sensitivity to known modulators have been investigated. For this, the three genes were introduced and overexpressed in the same cellular background, that of Chinese hamster LR73
Transmission of cell stress from endoplasmic reticulum to mitochondria: enhanced expression of Lon protease.
Journal:J Cell Biol
PubMed ID:12082077
'The rat homologue of a mitochondrial ATP-dependent protease Lon was cloned from cultured astrocytes exposed to hypoxia. Expression of Lon was enhanced in vitro by hypoxia or ER stress, and in vivo by brain ischemia. These observations suggested that changes in nuclear gene expression (Lon) triggered by ER stress had
Analysis of P-glycoprotein-mediated membrane transport in human peripheral blood lymphocytes using the UIC2 shift assay.
Journal:Cytometry A
PubMed ID:12766968
'BACKGROUND: During transport-associated adenosine triphosphate hydrolysis, P-glycoprotein (Pgp) undergoes conformation transitions detected by UIC2, a functional anti-Pgp monoclonal antibody. A newly developed UIC2 shift assay is based on increased UIC2 reactivity in the presence of Pgp substrates. All peripheral blood leukocytes express low Pgp levels. The existing antibody-based detection methods
Left-handed Z-DNA in bands of acid-fixed polytene chromosomes.
Journal:Proc Natl Acad Sci U S A
PubMed ID:6410390
'Antibodies to DNA in the left-handed (Z) conformation bind to acid-fixed polytene chromosomes of both Chironomus thummi and Drosophila melanogaster, as shown by direct and indirect immunofluorescence. Comparison of the phase-contrast, immunofluorescence, and DNA staining patterns shows a predominant localization of the antibody to the regions of high contrast and
Neurotrophic factors prevent ceramide-induced apoptosis downstream of c-Jun N-terminal kinase activation in PC12 cells.
Journal:J Neurochem
PubMed ID:9648862
'Neurotrophic factors prevent apoptosis of PC12 cells in serum-free medium. The present study determines whether neurotrophic factors can prevent ceramide-induced apoptosis in PC12 cells and investigates the role that c-Jun N-terminal kinase (JNK) activation may play in this system. Ceramide-induced apoptosis was inhibited by nerve growth factor, basic fibroblast growth
72 total citations